Tailored fluorogenic substrate library with natural / unnatural amino acids in search for specific substrates of matrix metalloproteases MMP2 and MMP9.
2014/13/B/ST5/00240
Keywords
Descriptors
- ST5_16: Chemia biologiczna
- ST5_23: Chemia organiczna
Panel
ST5 – Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering
Host institution
Politechnika Wrocławska, Wydział Chemiczny
Voivodeship: dolnośląskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 4
Call
OPUS 7 – announced on 2014-03-17
- Amount awarded
- 923 700 PLN
- Project start date
- 2015-02-06
- Project end date
- 2018-02-05
- Project duration
- 36 months (the same as in the proposal)
- Project status
- Project settled
Equipment purchased [PL]
- Kamera do mikroskopu fluorescencyjnego. Cost: 77 748 PLN
- Spektrofluorymetr płytkowy. Cost: 100 000 PLN
- Zestaw do Western Blot. Cost: 11 090 PLN
Information in the final report
Publication in academic press/journals (3)
-
Protease Specificity: Towards In Vivo Imaging Applications and Biomarker Discovery
- Authors:
- Matej Vizovišek, Robert Vidmar, Marcin Drag, Marko Fonovic, Guy S. Salvesen, Boris Turk
- Academic press:
- Trends in Biochemical Sciences (year: 2018, volume: 43, 10, pages: 829-844), Publisher: Cell Press
- Status:
- Published
- DOI:
- 10.1016/j.tibs.2018.07.003 – link to the publication
-
Emerging challenges in the design of selective substrates, inhibitors and activity-based probes for indistinguishable proteases.
- Authors:
- Kasperkiewicz P, Poreba M, Groborz K, Drag M.
- Academic press:
- FEBS Journal (year: 2017, volume: 284(10), pages: 1518-1539), Publisher: Wiley
- Status:
- Published
- DOI:
- 10.1111/febs.14001. – link to the publication
-
Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families
- Authors:
- Poreba M, Szalek A, Rut W, Kasperkiewicz P, Rutkowska-Wlodarczyk I, Snipas SJ, Itoh Y, Turk D, Turk B, Overall CM, Kaczmarek L, Salvesen GS, Drag M
- Academic press:
- Scientific Reports (year: 2017, volume: 7, pages: 1-13 43135), Publisher: Nature Publishing Group
- Status:
- Published
- DOI:
- 10.1038/srep43135 – link to the publication
Book publications / chapters in book publications (1)
-
Screening combinatorial peptide libraries in protease inhibitor drug discovery
- Authors:
- Marcin Poreba, Paulina Kasperkiewicz, Wioletta Rut, Marcin Drąg
- Book:
- Extracellular Targeting of Cell Signaling in Cancer: Strategies Directed at MET and RON Receptor Tyrosine Kinase Pathways (year: 2018, volume: 11, pages: 307-337), Publisher: Wiley
- Status:
- Published
- DOI:
- link to the publication