Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Tailored fluorogenic substrate library with natural / unnatural amino acids in search for specific substrates of matrix metalloproteases MMP2 and MMP9.

2014/13/B/ST5/00240

Keywords:

protease fluorogenic substrate matrix metalloprotease

Descriptors:

  • ST5_16:
  • ST5_23:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Politechnika Wrocławska, Wydział Chemiczny

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Marcin Drąg 

Number of co-investigators in the project: 4

Call: OPUS 7 - announced on 2014-03-17

Amount awarded: 923 700 PLN

Project start date (Y-m-d): 2015-02-06

Project end date (Y-m-d): 2018-02-05

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Kamera do mikroskopu fluorescencyjnego (77 748 PLN)
  2. Spektrofluorymetr płytkowy (100 000 PLN)
  3. Zestaw do Western Blot (11 090 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Book publications / chapters in book publications (1)
  1. Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families
    Authors:
    Poreba M, Szalek A, Rut W, Kasperkiewicz P, Rutkowska-Wlodarczyk I, Snipas SJ, Itoh Y, Turk D, Turk B, Overall CM, Kaczmarek L, Salvesen GS, Drag M
    Academic press:
    Scientific Reports (rok: 2017, tom: 7, strony: 1-13 43135), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/srep43135 - link to the publication
  2. Protease Specificity: Towards In Vivo Imaging Applications and Biomarker Discovery
    Authors:
    Matej Vizovišek, Robert Vidmar, Marcin Drag, Marko Fonovic, Guy S. Salvesen, Boris Turk
    Academic press:
    Trends in Biochemical Sciences (rok: 2018, tom: 43, 10, strony: 829-844), Wydawca: Cell Press
    Status:
    Published
    DOI:
    10.1016/j.tibs.2018.07.003 - link to the publication
  3. Emerging challenges in the design of selective substrates, inhibitors and activity-based probes for indistinguishable proteases.
    Authors:
    Kasperkiewicz P, Poreba M, Groborz K, Drag M.
    Academic press:
    FEBS Journal (rok: 2017, tom: 284(10), strony: 1518-1539), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/febs.14001. - link to the publication
  1. Screening combinatorial peptide libraries in protease inhibitor drug discovery
    Authors:
    Marcin Poreba, Paulina Kasperkiewicz, Wioletta Rut, Marcin Drąg
    Book:
    Extracellular Targeting of Cell Signaling in Cancer: Strategies Directed at MET and RON Receptor Tyrosine Kinase Pathways (rok: 2018, tom: 11, strony: 307-337), Wydawca: Wiley
    Status:
    Published
    DOI:
    link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy