Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Mechanisms of MMP-3 protease involvement in plasticity of glutamatergic and GABAergic synapses: impact of MMP-3 and MMP-9 interplay and the role of L-type calcium channels

2014/15/B/NZ4/01689

Keywords:

synaptic plasticity GABAergic trnamisssion glutamatergic transmission hippocampus

Descriptors:

  • NZ4_7: Neurophysiology
  • NZ4_9: Systems neurobiology
  • NZ3_6: Cell neurobiology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Wrocławski, Wydział Nauk Biologicznych

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Jerzy Mozrzymas 

Number of co-investigators in the project: 3

Call: OPUS 8 - announced on 2014-09-15

Amount awarded: 783 120 PLN

Project start date (Y-m-d): 2015-07-22

Project end date (Y-m-d): 2018-07-21

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Mikroskop z kontrastem DIC i fluorescencją (136 000 PLN)
  2. Platforma do mocowania manipulatorów (20 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (5)
  • Book publications / chapters in book publications (1)
  1. Mechanisms of NMDA Receptor- and Voltage-Gated L-Type Calcium Channel-Dependent Hippocampal LTP Critically Rely on Proteolysis That Is Mediated by Distinct Metalloproteinases
    Authors:
    Wiera G, Nowak D, van Hove I, Dziegiel P, Moons L, Mozrzymas JW
    Academic press:
    J Neurosci (rok: 2017, tom: 1;37(5), strony: 1240-1256), Wydawca: Sosciety for neuroscience
    Status:
    Published
    DOI:
    10.1523/JNEUROSCI.2170-16.2016 - link to the publication
  2. Multifaceted Roles of Metzincins in CNS Physiology and Pathology: From Synaptic Plasticity and Cognition to Neurodegenerative Disorders.
    Authors:
    Brzdak P, Nowak D, Wiera G, Mozrzymas JW.
    Academic press:
    Front Cell Neurosci. (rok: 2017, tom: 11, strony: 45313), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fncel.2017.00178 - link to the publication
  3. Spike Timing-Dependent Plasticity in the Mouse Barrel Cortex Is Strongly Modulated by Sensory Learning and Depends on Activity of Matrix Metalloproteinase 9
    Authors:
    Lebida K, Mozrzymas JW
    Academic press:
    Mol Neurobiol (rok: 2017, tom: 54(9), strony: 6723-6736), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12035-016-0174-y - link to the publication
  4. Extracellular proteolysis in structural and functional plasticity of mossy fiber synapses in hippocampus
    Authors:
    Wiera G, Mozrzymas JW
    Academic press:
    Front. Cell. Neurosci (rok: 2015, tom: 9, Article 427, strony: 45312), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fncel.2015.00427 - link to the publication
  5. MMP-3 deficiency does not influence the length and number of CA1 dendrites of hippocampus of adult mice
    Authors:
    Daria Nowak, Lies De Groef, Lieve Moons and Jerzy W. Mozrzymas
    Academic press:
    Acta Neurobiologiae Experimentalis (rok: 2018, tom: 78, strony: 281–286), Wydawca: Nencki Institute of Experimental Biology, Polish Neuroscience Society
    Status:
    Published
    DOI:
    10.21307/ane‑2018‑026 - link to the publication
  1. Different impact of MMP-3 activity on long–term potentiation, long–term depression and depotentiation
    Authors:
    Anna Lech, Daria Nowak, Grzegorz Wiera, Jerzy W. Mozrzymas
    Conference:
    7th Aspects of Neuroscience (rok: 2017, ), Wydawca: Faculty of Biology University of Warsaw
    Data:
    konferencja 24-26.11
    Status:
    Published
  2. Long-Term Plasticity of inhibitory synaptic transmission in hippocampus strongly depends on the activity of MMP-3
    Authors:
    Katarzyna Lebida, Patrycja Brzdąk, Jerzy W. Mozrzymas
    Conference:
    Neuronus 2018 (rok: 2018, ), Wydawca: Neuronus FENS Forum
    Data:
    konferencja 20-22 kwiecień
    Status:
    Published
    DOI:
    link to the publication
  3. Impact of matrix metalloproteinases on long-term GABAergic synaptic plasticity in the Sch-CA1 hippocampal projection
    Authors:
    Lebida K, Brzdak P , Mozrzymas JW
    Conference:
    FENS Regional Meeting Pécs 2017 (rok: 2017, ), Wydawca: FENS Regional Meeting Pécs 2017
    Data:
    konferencja 20-23.09.2017
    Status:
    Published
    DOI:
    link to the publication
  4. Long-term GABAergic synaptic plasticity in hippocampus strongly depends on the activity of matrix metalloproteinase-3
    Authors:
    Brzdąk P, Lebida K, Lech A, Nowak D, Wiera G, Mozrzymas JW
    Conference:
    XI Konferencja Elektrofizjologiczna (rok: 2018, ), Wydawca: Instytut Biologii Doświadczalnej im. Nenckiego
    Data:
    konferencja 25 - 26.05
    Status:
    Published
  5. Matrix Metalloprotease 3 supports postsynaptic long-term GABAergic synaptic plasticity in the hippocampus
    Authors:
    Patrycja Brzdak, Katarzyna Lebida, Jerzy Mozrzymas
    Conference:
    11th FENS Forum of Neuroscience (rok: 2018, ), Wydawca: 11th FENS Forum of Neuroscience
    Data:
    konferencja 07 - 11.07
    Status:
    Published
    DOI:
    link to the publication
  1. Wpływ metaloproteinaz na plastyczność synaptyczną i procesy kognitywne: rola w patomechanizmie otępienia
    Authors:
    Wójtowicz T, Wiera G, Mozrzymas JW
    Book:
    Choroba Alzheimera - wybrane zagadnienia biologiczne i kliniczne (rok: 2016, tom: 1, strony: 149-184), Wydawca: Wydawnictwo Continuo
    Status:
    Published

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