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Combinatorial peptide libraries modified by ionization tags on solid support for investigation of new substrates of proteases.

2015/17/D/ST5/01329

Keywords:

ionization tags combinatorial libraries high-resolution mass spectrometry proteases substrates

Descriptors:

  • ST5_16:
  • ST5_23:
  • ST4_10: Polymer and biopolymer chemistry

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet Wrocławski, Wydział Chemii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Remigiusz Bąchor 

Number of co-investigators in the project: 3

Call: SONATA 9 - announced on 2015-03-16

Amount awarded: 481 000 PLN

Project start date (Y-m-d): 2016-02-01

Project end date (Y-m-d): 2020-01-31

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Wysokowydajny komputer (5 000 PLN)
  2. Zamrażarka (do -85 ˚C) z szufladami do przechowywania enzymów i próbek. (50 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (2)
  1. Synthesis and mass spectrometry analysis of mimosine-containing peptides
    Authors:
    Remigiusz Bąchor, Enrico Randaccio, Joanna I. Lachowicz, Piotr Stefanowicz, Valeria M. Nurchi, Zbigniew Szewczuk
    Academic press:
    International Journal of Peptide Research and Therapeutics (rok: 2021, tom: 27, strony: 379-384), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s10989-020-10092-w - link to the publication
  2. Metal self-assembly mimosine peptides with enhanced antimicrobial activity: towards a new generation of multitasking chelating agents
    Authors:
    Joanna Izabela Lachowicz, Gabriele Dalla Torre, Rosita Cappai, Enrico Randaccio, Valeria M. Nurchi, Remigiusz Bąchor, Zbigniew Szewczuk, Łukasz Jaremko, Mariusz Jaremko, Maria Barbara Pisano, Sofia Cosentino, Germano Orrù, Antonella Ibba, Joni Mujika, Xabier Lopez
    Academic press:
    Dalton Transactions (rok: 2020, tom: 49, strony: 2862-2879), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c9dt04545g - link to the publication
  3. Peptidyl-resin substrates as a tool in the analysis of caspase activity
    Authors:
    Remigiusz Bąchor
    Academic press:
    Molecules (rok: 2022, ), Wydawca: MDPI
    Status:
    Submitted
    DOI:
    brak - link to the publication
  4. Veni, Vidi, Vici: immobilized peptide-based conjugates as tools for capture, analysis, and transformation.
    Authors:
    Kowalska Marta, Popiel Dominik, Walter Martyna, Bąchor Remigiusz, Biernat Monika, Cebrat Marek, Kijewska Monika, Kuczer Mariola, Modzel Maciej, Kluczyk Alicja
    Academic press:
    Chemosensors (rok: 2022, tom: 10, strony: 31/1-31/26), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/chemosensors10010031 - link to the publication
  5. Application of 5-amino-3-methyl-isoxazole-4-carboxylic acid as a new β-amino acid in the solid phase peptide synthesis
    Authors:
    Urszula Bąchor, Agnieszka Lizak, Remigiusz Bąchor, Marcin Mączyński
    Academic press:
    Molecules , Wydawca: MDPI
    Status:
    Submitted
    DOI:
    BRAK - link to the publication
  1. On-bead analysis of substrate specificity of caspases using peptide modified by quaternary ammonium group as ionization enhancers
    Authors:
    Remigiusz Bąchor, Aneta Paluch, Wioletta Rut, Marcin Drąg, Zbigniew Szewczuk
    Conference:
    35th European Peptide Symposium (rok: 2018, ), Wydawca: Wiley JOURNAL OF PEPTIDE SCIENCE
    Data:
    konferencja 26-31.09
    Status:
    Published
  2. Combinatorial peptide libraries modified by ionization tags on solid support for investigation of new substrates of proteases.
    Authors:
    Remigiusz Bąchor, Alicja Kluczyk, Zbigniew Szewczuk
    Conference:
    34th European Peptide Symposium (rok: 2016, ), Wydawca: Wiley
    Data:
    konferencja 04-09.09
    Status:
    Published

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