Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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"Obesity paradox" in sepsis: involvement of trinity of IL-33, neutrophil elastase and neutrophil extracellular traps (NETs)

2014/15/B/NZ6/02519

Keywords:

sepsis neutrophil NET neutrophil extracellular traps neutrophil elastase proteases IL-33

Descriptors:

  • NZ6_1: Adaptive and innate immunity

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Jagielloński, Wydział Biologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Elżbieta Kołaczkowska 

Number of co-investigators in the project: 5

Call: OPUS 8 - announced on 2014-09-15

Amount awarded: 1 398 900 PLN

Project start date (Y-m-d): 2015-07-24

Project end date (Y-m-d): 2019-02-23

Project duration:: 43 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Mikroskop diagnostyczny z modułem konfokalnym typu spinning disk (500 000 PLN)
  2. dysk twardy.
  3. motoryzacja stolika do posiadanego mikroskopu Zeiss Axio Imager SCAN 130 x 85 w osi X-Y (50 000 PLN)
  4. Waga analityczna (3 138 PLN)

Information in the final report

  • Publication in academic press/journals (13)
  1. Challenges in 3D culturing of neutrophils: Assessment of cell viability
    Authors:
    Gonzalez Gonzalez Miriam, Cichon Iwona, Scislowska-Czarnecka Anna, Kolaczkowska Elzbieta
    Academic press:
    Journal of Immunological Methods (rok: 2018, tom: 457, strony: 73-77), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jim.2018.02.015 - link to the publication
  2. Jak chronić biomateriały przed układem odpornościowym?
    Authors:
    Ścisłowska-Czarnecka Anna, Kołaczkowska Elżbieta
    Academic press:
    Kosmos (rok: 2017, tom: 66, strony: 677–689), Wydawca: Polskie Towarzystwo Przyrodników im. Kopernika
    Status:
    Published
  3. Platelets and neutrophil extracellular traps collaborate to promote intravascular coagulation during sepsis in mice
    Authors:
    McDonald Braedon, Davis Rachelle P, Kim Seok-Joo, Tse Mandy, Esmon Charles T, Kolaczkowska Elzbieta*, Jenne Craig N* (*equal contribution)
    Academic press:
    Blood (rok: 2017, tom: 129, strony: 1357-1367), Wydawca: American Society of Hematology
    Status:
    Published
    DOI:
    10.1182/blood-2016-09-741298 - link to the publication
  4. Age is the work of art? Impact of neutrophil and organism age on neutrophil extracellular trap formation
    Authors:
    Ortmann Weronika, Kolaczkowska Elzbieta
    Academic press:
    Cell and Tissue Research (rok: 2018, tom: 371, strony: 473-488), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00441-017-2751-4 - link to the publication
  5. Scrutinizing Mechanisms of the 'Obesity Paradox in Sepsis': Obesity Is Accompanied by Diminished Formation of Neutrophil Extracellular Traps (NETs) Due to Restricted Neutrophil– Platelet Interactions
    Authors:
    Iwona Cichon, Weronika Ortmann, Michal Santocki, Malgorzata Opydo-Chanek, Elzbieta Kolaczkowska
    Academic press:
    Cells (rok: 2021, tom: 10, strony: 45320), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10020384 - link to the publication
  6. Wyrzut zewnątrzkomórkowych sieci neutrofilowych (NET) przez neutrofile i co dalej? Konsekwencje tworzenia i nieprawidłowego usuwania NET
    Authors:
    Santocki Michał, Kołaczkowska Elżbieta
    Academic press:
    Kosmos (rok: 2017, tom: 66, strony: 623–634), Wydawca: Polskie Towarzystwo Przyrodników im. Kopernika
    Status:
    Published
  7. CXCL9-Derived Peptides Differentially Inhibit Neutrophil Migration In Vivo through Interference with Glycosaminoglycan Interactions
    Authors:
    Vanheule Vincent, Boff Daiane, Mortier Anneleen, Janssens Rik, Petri Bjorn, Kolaczkowska Elzbieta, Kubes Paul, Berghmans Nele, Struyf Sofie, Kungl Andreas J, Teixeira Mauro Martins, Amaral Flavio Amaral, Proost Paul
    Academic press:
    Frontiers in Immunology (rok: 2017, tom: 8, strony: 45305), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fimmu.2017.00530 - link to the publication
  8. Conservative Mechanisms of Extracellular Trap Formation by Annelida Eisenia andrei: Serine Protease Activity Requirement
    Authors:
    Homa Joanna, Ortmann Weronika, Kolaczkowska Elzbieta
    Academic press:
    PLoS One (rok: 2016, tom: 11, strony: e0159031), Wydawca: San Francisco, CA: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0159031. - link to the publication
  9. Dziedzictwo Illii Miecznikowa: w stulecie śmierc
    Authors:
    Kołaczkowska Elżbieta
    Academic press:
    Kosmos (rok: 2017, tom: 66, strony: 531-540), Wydawca: Polskie Towarzystwo Przyrodników im. Kopernika
    Status:
    Published
  10. Długie życie neutrofila? Kontrowersje dotyczące długości życia neutrofili w krążeniu
    Authors:
    Cichoń Iwona, Santocki Michał, Wierzbicka Katarzyna, Kołaczkowska Elżbieta
    Academic press:
    Postępy Biologii Komórki (rok: 2017, tom: 44, strony: 111–132), Wydawca: Fundacja Biologii Komórki i Biologii Molekularnej
    Status:
    Published
  11. Immunometabolizm czyli jak procesy biochemiczne kontrolują funkcje obronne leukocytów
    Authors:
    Cichoń Iwona, Kołaczkowska Elżbieta
    Academic press:
    Kosmos (rok: 2017, tom: 66, strony: 635–649), Wydawca: Polskie Towarzystwo Przyrodników im. Kopernika
    Status:
    Published
  12. Reduced Neutrophil Extracellular Trap (NET) Formation During Systemic Inflammation in Mice With Menkes Disease and Wilson Disease: Copper Requirement for NET Release
    Authors:
    Iwona Cichon, Weronika Ortmann, Aleksandra Bednarz, Malgorzata Lenartowicz, Elzbieta Kolaczkowska
    Academic press:
    Frontiers in Immunology (rok: 2020, tom: 10, strony: 45308), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fimmu.2019.03021 - link to the publication
  13. To NET or not to NET: current opinions and state of the science regarding the formation of neutrophil extracellular traps
    Authors:
    Boeltz S, Amini P, Anders HJ, Andrade F, Bilyy R, Chatfield S, Cichon I, Clancy DM, Desai J, Dumych T, Dwivedi N, Gordon RA, Hahn J, Hidalgo A, Hoffmann MH, Kaplan MJ, Knight JS, Kolaczkowska E, Kubes P, Leppkes M, Manfredi AA, Martin SJ, Maueröder C, Maugeri N, Mitroulis I, Munoz LE, Nakazawa D, Neeli I, Nizet V, Pieterse E, Radic MZ, Reinwald C, Ritis K, Rovere-Querini P, Santocki M, Schauer C, Schett G, Shlomchik MJ, Simon HU, Skendros P, Stojkov D, Vandenabeele P, Berghe TV, van der Vlag J, Vitkov L, von Köckritz-Blickwede M, Yousefi S, Zarbock A, Herrmann M
    Academic press:
    Cell Death & Differentiation (rok: 2019, tom: 26, strony: 395-408), Wydawca: London: Edward Arnold
    Status:
    Published
    DOI:
    10.1038/s41418-018-0261-x - link to the publication