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Information on the principal investigator and host institution

Information of the project and the call

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Biochemical and physiological characterization of human protease HtrA3

2013/09/B/NZ1/01068

Keywords:

HtrA3 protease activation mechanism physiological substrates

Descriptors:

  • NZ1_1: Molecular biology
  • NZ1_2: Biochemistry
  • NZ1_4: Structural biology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Gdański, Wydział Biologii

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Barbara Lipińska 

Number of co-investigators in the project: 6

Call: OPUS 5 - announced on 2013-03-15

Amount awarded: 648 000 PLN

Project start date (Y-m-d): 2014-02-12

Project end date (Y-m-d): 2017-08-11

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Inkubator CO2 (30 000 PLN)
  2. Notebook.
  3. Mikroskop odwrócony (30 000 PLN)
  4. Spektrofluorymetr z czytnikiem płytek (120 000 PLN)
  5. Łaźnia wodna.

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (9)
  1. Selection of Effective HTRA3 Activators Using Combinatorial Chemistry
    Authors:
    Magdalena Wysocka, Kamila Sychowska, Natalia Gruba, Ł ukasz Winiarski, Marcin Skoreński, Mateusz Psurski, Joanna Makowska, Artur Giełdoń, Tomasz Wenta, Mirosław Jarząb, Przemysław Glaza, Joanna Zdancewicz, Marcin Sienczyk, Barbara Lipińska and Adam Lesner
    Academic press:
    ACS Combinatorial Science (rok: 2017, tom: 19, strony: 565-573), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acscombsci.7b00051 - link to the publication
  2. Structural and Functional Analysis of Human HtrA3 protease and Its Subdomains
    Authors:
    P. Glaza, J. Osipiuk , T. Wenta, D. Zurawa-Janicka, M. Jarzab, A. Lesner, B. Banecki, J. Skórko-Glonek, A. Joachimiak, B. Lipinska
    Academic press:
    PLOS ONE (rok: 2015, tom: 10(6), strony: e0131142), Wydawca: PLOS ONE
    Status:
    Published
    DOI:
    10.1371/journal.pone.0131142 - link to the publication
  3. HtrA3 is a cellular partner of cytoskeleton proteins and TCP1α chaperonin
    Authors:
    Tomasz Wenta, Dorota Zurawa-Janicka, Michal Rychlowski, Miroslaw Jarzab, Przemyslaw Glaza, Andrea Lipinska, Krystyna Bienkowska-Szewczyk, Anna Herman- Antosiewicz, Joanna Skorko-Glonek and Barbara Lipinska
    Academic press:
    Journal of Proteomics (rok: 2018, tom: 177, strony: 88-111), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jprot.2018.02.022 - link to the publication
  4. Structural insights into the activation mechanisms of human HtrA serine proteases
    Authors:
    Dorota Żurawa-Janicka, Tomasz Wenta, Mirosław Jarząb, Joanna Skorko- Glonek, Przemysław Glaza, Artur Giełdoń, Jerzy Ciarkowski, Barbara Lipińska
    Academic press:
    Archives of Biochemistry and Biophysics (rok: 2017, tom: 621, strony: 45466), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.abb.2017.04.004 - link to the publication
  5. The HtrA3 protease promotes drug-induced death of lung cancer cells by cleavage of the X-linked inhibitor of apoptosis protein (XIAP)
    Authors:
    Tomasz Wenta, Michal Rychlowski, Ewelina Jurewicz, Miroslaw Jarzab, Dorota Zurawa-Janicka, Anna Filipek and Barbara Lipinska
    Academic press:
    Cell Death and Disease (rok: 2018, ), Wydawca: Nature Publishing Group
    Status:
    Submitted
    DOI:
    brak - link to the publication
  6. The role of the LB structural loop and its interactions with the PDZ domain of the human HtrA3 protease
    Authors:
    Tomasz Wenta, Przemysław Glaza, Mirosław Jarząb, Urszula Zarzecka, Dorota Żurawa-Janicka, Adam Lesner, Joanna Skórko-Glonek, Barbara Lipińska
    Academic press:
    BBA - Proteins and Proteomics (rok: 2017, tom: 1865, strony: 1141-1151), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbapap.2017.06.013 - link to the publication
  1. A role of the unique interactions between the LB loop of protease domain with the PDZ domain of the human pro-apoptotic HtrA3 protease
    Authors:
    Tomasz Wenta, Przemysław Glaza, Dorota Żurawa-Janicka, Andrea Lipińska, Barbara Lipińska.
    Conference:
    VIIIth International Symposium on Heat Shock Proteins in Biology and Medicine: Stress Responses in Health & Disease (rok: 2016, ), Wydawca: Cell Stress Society International
    Data:
    konferencja Alexandria, VA, 29 October - 2 November
    Status:
    Published
  2. Biochemical characterization of human HtrA3 protease functioning as a proapoptotic factor and tumor suppressor
    Authors:
    Tomasz Wenta, Przemysław Glaza, Jerzy Osipiuk, Dorota Żurawa-Janicka, Andrzej Joachimiak, Magdalena Wysocka, Barbara Lipińska
    Conference:
    II International Student Conference of Cell Biology (rok: 2016, ), Wydawca: Jagiellonan University, Kraków, Poland
    Data:
    konferencja Krakow, Poland, 1-2 April
    Status:
    Published
  3. Biochemical characterization of human HtrA3 protease functioning as a tumor suppressor
    Authors:
    Tomasz Wenta, Przemysław Glaza, Jerzy Osipiuk, Dorota Żurawa-Janicka, Andrzej Joachimiak, Monika Bobrycka, Barbara Lipińska
    Conference:
    The Frontiers in Cancer Prevention: Fulfilled Promises, Translational Challenges and Future Directions (rok: 2015, ), Wydawca: Polish Biochemical Society &Polish Academy of Sciences Committee of Biochemistry and Biophysics
    Data:
    konferencja 24-27 June 2015
    Status:
    Published
  4. The proteolytic activity and oligomerization status of the human HtrA3 protease functioning as a tumor suppressor
    Authors:
    Przemysław Glaza, Tomasz Wenta, Jerzy Osipiuk, Agnieszka Kowalska, Ewa Gębal, Dorota Żurawa-Janicka, Adam Lesner, Barbara Lipińska
    Conference:
    29th Annual Symposium of The Protein Society, (rok: 2015, ), Wydawca: The Protein Society
    Data:
    konferencja 22-25 July 2015
    Status:
    Published
  5. HtrA proteins as possible targets in cancer therapy
    Authors:
    Mirosław Jarzab, Tomasz Wenta, Przemysław Glaza, Dorota Zurawa-Janicka, Agnieszka Polit, Jerzy Ciarkowski, Barbara Lipinska
    Conference:
    The 19th World Congress on Advances in Oncology and 17th Symposium on Molecular Medicine (rok: 2014, ), Wydawca: International Journal of Molecular Medicine, vol 34, Supplement 1, S28, 2014
    Data:
    konferencja 9-11 October, 2014, Athens, Greece
    Status:
    Published
  6. Synthesis of allosteric activators of HtrA3 using combinatorial chemistry method
    Authors:
    Magdalena Wysocka, Kamila Sychowska, Natalia Gruba, Tomasz Wenta, Renata Grzywa, Marcin Sieńczyk, Barbara Lipińska, Krzysztof Rolka, Adam Lesner
    Conference:
    23rd Polish Peptide Symposium (rok: 2015, ), Wydawca: The European Peptide Society
    Data:
    konferencja 30 August - 3 September 2015
    Status:
    Published
  7. A role of the unique PD-PDZ interactions in the HtrA3 protease
    Authors:
    Przemysław Glaza, Tomasz Wenta, Jerzy Osipiuk, Magdalena Jaskółkowska, Adam Lesner, Barbara Lipińska
    Conference:
    Second Polish - Korean Conference on Protein Folding: Theoretical and Experimental Approaches (rok: 2016, ), Wydawca: KIAS ; University of Gdańsk
    Data:
    konferencja Leźno, Gdańsk, Poland, 28 May - 1 June
    Status:
    Published
    DOI:
    link to the publication
  8. Identification of the cellular substrates of the pro-apoptotic HtrA3 protease/chaperone
    Authors:
    Tomasz Wenta, Przemysław Glaza, Dorota Żurawa-Janicka, Andrea Lipińska, Barbara Lipińska.
    Conference:
    Identification of the cellular substrates of the pro-apoptotic HtrA3 protease/chaperone (rok: 2016, ), Wydawca: Cell Stress Society International
    Data:
    konferencja Alexandria, VA, 29 October - 2 November
    Status:
    Published
    DOI:
    link to the publication
  9. Characteristics of structure and proteolytic activity of human HtrA3 protease functioning as a proapoptotic factor and tumor suppressor
    Authors:
    Tomasz Wenta, Przemysław Glaza, J. Osipiuk, Dominika Raszewska, Dorota Żurawa-Janicka, A. Joachimiak, Barbara Lipińska
    Conference:
    International Conference of Biophysics Students (rok: 2015, ), Wydawca: Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University
    Data:
    konferencja 22-24 May 2015
    Status:
    Published

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