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Biochemical and physiological characterization of human protease HtrA3

2013/09/B/NZ1/01068

Keywords

Descriptors

  • NZ1_1: Biologia molekularna
  • NZ1_2: Biochemia
  • NZ1_4: Biologia strukturalna

Panel

NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution

Uniwersytet Gdański, Wydział Biologii

Voivodeship: pomorskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Barbara Lipińska

Number of co-investigators in the project: 6

Call

OPUS 5 – announced on 2013-03-15

Amount awarded
648 000 PLN
Project start date
2014-02-12
Project end date
2017-08-11
Project duration
42 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Inkubator CO2. Cost: 30 000 PLN
  2. Mikroskop odwrócony. Cost: 30 000 PLN
  3. Notebook.
  4. Spektrofluorymetr z czytnikiem płytek. Cost: 120 000 PLN
  5. Łaźnia wodna.

Information in the final report

Publication in academic press/journals (5)

  1. Structural and Functional Analysis of Human HtrA3 protease and Its Subdomains

    Authors:
    P. Glaza, J. Osipiuk , T. Wenta, D. Zurawa-Janicka, M. Jarzab, A. Lesner, B. Banecki, J. Skórko-Glonek, A. Joachimiak, B. Lipinska
    Academic press:
    PLOS ONE (year: 2015, volume: 10(6), pages: e0131142), Publisher: PLOS ONE
    Status:
    Published
    DOI:
    10.1371/journal.pone.0131142 – link to the publication

  2. The role of the LB structural loop and its interactions with the PDZ domain of the human HtrA3 protease

    Authors:
    Tomasz Wenta, Przemysław Glaza, Mirosław Jarząb, Urszula Zarzecka, Dorota Żurawa-Janicka, Adam Lesner, Joanna Skórko-Glonek, Barbara Lipińska
    Academic press:
    BBA - Proteins and Proteomics (year: 2017, volume: 1865, pages: 1141-1151), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbapap.2017.06.013 – link to the publication

  3. Structural insights into the activation mechanisms of human HtrA serine proteases

    Authors:
    Dorota Żurawa-Janicka, Tomasz Wenta, Mirosław Jarząb, Joanna Skorko- Glonek, Przemysław Glaza, Artur Giełdoń, Jerzy Ciarkowski, Barbara Lipińska
    Academic press:
    Archives of Biochemistry and Biophysics (year: 2017, volume: 621, pages: 46196), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.abb.2017.04.004 – link to the publication

  4. Selection of Effective HTRA3 Activators Using Combinatorial Chemistry

    Authors:
    Magdalena Wysocka, Kamila Sychowska, Natalia Gruba, Ł ukasz Winiarski, Marcin Skoreński, Mateusz Psurski, Joanna Makowska, Artur Giełdoń, Tomasz Wenta, Mirosław Jarząb, Przemysław Glaza, Joanna Zdancewicz, Marcin Sienczyk, Barbara Lipińska and Adam Lesner
    Academic press:
    ACS Combinatorial Science (year: 2017, volume: 19, pages: 565-573), Publisher: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acscombsci.7b00051 – link to the publication

  5. HtrA3 is a cellular partner of cytoskeleton proteins and TCP1α chaperonin

    Authors:
    Tomasz Wenta, Dorota Zurawa-Janicka, Michal Rychlowski, Miroslaw Jarzab, Przemyslaw Glaza, Andrea Lipinska, Krystyna Bienkowska-Szewczyk, Anna Herman- Antosiewicz, Joanna Skorko-Glonek and Barbara Lipinska
    Academic press:
    Journal of Proteomics (year: 2018, volume: 177, pages: 88-111), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jprot.2018.02.022 – link to the publication

Articles in post-conference publications (9)

  1. Biochemical characterization of human HtrA3 protease functioning as a proapoptotic factor and tumor suppressor

    Authors:
    Tomasz Wenta, Przemysław Glaza, Jerzy Osipiuk, Dorota Żurawa-Janicka, Andrzej Joachimiak, Magdalena Wysocka, Barbara Lipińska
    Conference:
    II International Student Conference of Cell Biology (year: 2016, pages: 60), Publisher: Jagiellonan University, Kraków, Poland
    Date:
    conference Krakow, Poland, 1-2 April
    Status:
    Published

  2. Synthesis of allosteric activators of HtrA3 using combinatorial chemistry method

    Authors:
    Magdalena Wysocka, Kamila Sychowska, Natalia Gruba, Tomasz Wenta, Renata Grzywa, Marcin Sieńczyk, Barbara Lipińska, Krzysztof Rolka, Adam Lesner
    Conference:
    23rd Polish Peptide Symposium (year: 2015, pages: 99), Publisher: The European Peptide Society
    Date:
    conference 30 August - 3 September 2015
    Status:
    Published

  3. A role of the unique PD-PDZ interactions in the HtrA3 protease

    Authors:
    Przemysław Glaza, Tomasz Wenta, Jerzy Osipiuk, Magdalena Jaskółkowska, Adam Lesner, Barbara Lipińska
    Conference:
    Second Polish - Korean Conference on Protein Folding: Theoretical and Experimental Approaches (year: 2016, pages: 50), Publisher: KIAS ; University of Gdańsk
    Date:
    conference Leźno, Gdańsk, Poland, 28 May - 1 June
    Status:
    Published
    DOI:
    link to the publication

  4. Characteristics of structure and proteolytic activity of human HtrA3 protease functioning as a proapoptotic factor and tumor suppressor

    Authors:
    Tomasz Wenta, Przemysław Glaza, J. Osipiuk, Dominika Raszewska, Dorota Żurawa-Janicka, A. Joachimiak, Barbara Lipińska
    Conference:
    International Conference of Biophysics Students (year: 2015, pages: 79), Publisher: Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University
    Date:
    conference 22-24 May 2015
    Status:
    Published

  5. A role of the unique interactions between the LB loop of protease domain with the PDZ domain of the human pro-apoptotic HtrA3 protease

    Authors:
    Tomasz Wenta, Przemysław Glaza, Dorota Żurawa-Janicka, Andrea Lipińska, Barbara Lipińska.
    Conference:
    VIIIth International Symposium on Heat Shock Proteins in Biology and Medicine: Stress Responses in Health & Disease (year: 2016, pages: 56), Publisher: Cell Stress Society International
    Date:
    conference Alexandria, VA, 29 October - 2 November
    Status:
    Published

  6. The proteolytic activity and oligomerization status of the human HtrA3 protease functioning as a tumor suppressor

    Authors:
    Przemysław Glaza, Tomasz Wenta, Jerzy Osipiuk, Agnieszka Kowalska, Ewa Gębal, Dorota Żurawa-Janicka, Adam Lesner, Barbara Lipińska
    Conference:
    29th Annual Symposium of The Protein Society, (year: 2015, pages: PB-054), Publisher: The Protein Society
    Date:
    conference 22-25 July 2015
    Status:
    Published

  7. Identification of the cellular substrates of the pro-apoptotic HtrA3 protease/chaperone

    Authors:
    Tomasz Wenta, Przemysław Glaza, Dorota Żurawa-Janicka, Andrea Lipińska, Barbara Lipińska.
    Conference:
    Identification of the cellular substrates of the pro-apoptotic HtrA3 protease/chaperone (year: 2016, pages: 60), Publisher: Cell Stress Society International
    Date:
    conference Alexandria, VA, 29 October - 2 November
    Status:
    Published

  8. HtrA proteins as possible targets in cancer therapy

    Authors:
    Mirosław Jarzab, Tomasz Wenta, Przemysław Glaza, Dorota Zurawa-Janicka, Agnieszka Polit, Jerzy Ciarkowski, Barbara Lipinska
    Conference:
    The 19th World Congress on Advances in Oncology and 17th Symposium on Molecular Medicine (year: 2014, pages: S28), Publisher: International Journal of Molecular Medicine, vol 34, Supplement 1, S28, 2014
    Date:
    conference 9-11 October, 2014, Athens, Greece
    Status:
    Published

  9. Biochemical characterization of human HtrA3 protease functioning as a tumor suppressor

    Authors:
    Tomasz Wenta, Przemysław Glaza, Jerzy Osipiuk, Dorota Żurawa-Janicka, Andrzej Joachimiak, Monika Bobrycka, Barbara Lipińska
    Conference:
    The Frontiers in Cancer Prevention: Fulfilled Promises, Translational Challenges and Future Directions (year: 2015, pages: 49), Publisher: Polish Biochemical Society &Polish Academy of Sciences Committee of Biochemistry and Biophysics
    Date:
    conference 24-27 June 2015
    Status:
    Published

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