Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Design and synthesis of acylpeptide hydrolase inhibitors as potential inducers of apoptosis in tumor cells

2013/09/N/ST5/02472

Keywords:

irreversible inhibitors APH acylpeptide hydrolase serine protease

Descriptors:

  • ST5_23:
  • ST5_16:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Politechnika Wrocławska, Wydział Chemiczny

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Maciej Walczak 

Number of co-investigators in the project: 2

Call: PRELUDIUM 5 - announced on 2013-03-15

Amount awarded: 100 000 PLN

Project start date (Y-m-d): 2014-04-14

Project end date (Y-m-d): 2016-07-13

Project duration:: 27 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (1)
  • Articles in post-conference publications (2)
  1. Phosphonic analogues of alanine as acylpeptide hydrolase inhibitors
    Authors:
    Maciej Walczak, Agnieszka Chryplewicz, Sandra Olewińska, Mateusz Psurski, Łukasz Winiarski, Karolina Torzyk, Józef Oleksyszyn, Marcin Sieńczyk
    Academic press:
    Chemistry & Biodiversity (rok: 2021, tom: 18, strony: e2001004), Wydawca: Wiley Online Library
    Status:
    Published
    DOI:
    10.1002/cbdv.202001004 - link to the publication
  1. Development of phosphonic analogues of alanine as acylpeptide hydrolase inhibitors
    Authors:
    Maciej Walczak, Agnieszka Chryplewicz, Sandra Olewińska, Marcin Sieńczyk, Józef Oleksyszyn
    Conference:
    23rd Polish Peptide Symposium (rok: 2015, ), Wydawca: Politechnika Łódzka
    Data:
    konferencja 42246
    Status:
    Published
  2. Development of phosphonic analogues of alanine as APH inhibitors and apoptosis inducers of cancer cells
    Authors:
    Maciej Walczak, Agnieszka Chryplewicz, Sandra Olewińsk, Marcin Sieńczyk, Józef Oleksyszyn
    Conference:
    Proteolytic Enzymes and Their Inhibitors Gordon Research Conference (rok: 2016, ), Wydawca: Gordon Research Conference
    Data:
    konferencja June 26 - July 1, 2016
    Status:
    Published

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