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Information on the principal investigator and host institution

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Selective activity based probes for imaging of active serine proteases in neutrophils.

2014/14/M/ST5/00619

Keywords:

activity based probe proteolytic enzyme imaging

Descriptors:

  • ST5_16:
  • ST5_23:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Politechnika Wrocławska, Wydział Chemiczny

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Marcin Drąg 

Number of co-investigators in the project: 5

Call: HARMONIA 6 - announced on 2014-06-16

Amount awarded: 1 030 880 PLN

Project start date (Y-m-d): 2015-05-25

Project end date (Y-m-d): 2018-05-24

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (5)
  1. Design of a Selective Substrate and Activity Based Probe for Human Neutrophil Serine Protease 4
    Authors:
    Paulina Kasperkiewicz, Marcin Poreba, Scott J. Snipas, S. Jack Lin, Daniel Kirchhofer, Guy S. Salvesen, Marcin Drag
    Academic press:
    Plos ONE (rok: 2015, tom: N/A, strony: 45303), Wydawca: PLOS
    Status:
    Published
    DOI:
    10.1371/journal.pone.0132818 - link to the publication
  2. Emerging challenges in the design of selective substrates, inhibitors and activity-based probes for indistinguishable proteases.
    Authors:
    Kasperkiewicz Paulina, Poręba Marcin, Groborz Katarzyna, Drąg Marcin
    Academic press:
    FEBS Journal (rok: 2017, tom: 10, strony: 1518-1539), Wydawca: WILEY-BLACKWELL
    Status:
    Published
    DOI:
    10.1111/febs.14001. - link to the publication
  3. Toolbox of Fluorescent Probes for Parallel Imaging Reveals Uneven Location of Serine Proteases in Neutrophils
    Authors:
    Paulina Kasperkiewicz, Yoav Altman, Maximiliano D'Angelo, Guy S. Salvesen, Marcin Drag
    Academic press:
    Journal of the American Chemical Society (rok: 2017, tom: 139, strony: 10115-10125), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/jacs.7b04394 - link to the publication
  4. Synthesis of a HyCoSuL peptide substrate library to dissect protease substrate specificity
    Authors:
    Marcin Poreba, Guy S Salvesen & Marcin Drag
    Academic press:
    Nature Protocols (rok: 2017, tom: vol.12, no.10, strony: 2189-2214), Wydawca: Macmillan Publishers Limited, part of Springer Nature.
    Status:
    Published
    DOI:
    10.1038/nprot.2017.091 - link to the publication
  5. Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families.
    Authors:
    Poreba M, Szalek A, Rut W, Kasperkiewicz P, Rutkowska-Wlodarczyk I, Snipas SJ, Itoh Y, Turk D, Turk B, Overall CM, Kaczmarek L, Salvesen GS, Drąg M
    Academic press:
    Scientific Reports (rok: 2017, tom: 7, strony: 1-13 43135), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/srep43135 - link to the publication

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