Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Selective activity based probes for imaging of active serine proteases in neutrophils.

2014/14/M/ST5/00619

Keywords:

activity based probe proteolytic enzyme imaging

Descriptors:

  • ST5_16:
  • ST5_23:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Politechnika Wrocławska, Wydział Chemiczny

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Marcin Drąg 

Number of co-investigators in the project: 5

Call: HARMONIA 6 - announced on 2014-06-16

Amount awarded: 1 030 880 PLN

Project start date (Y-m-d): 2015-05-25

Project end date (Y-m-d): 2018-05-24

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (5)
  1. Design of a Selective Substrate and Activity Based Probe for Human Neutrophil Serine Protease 4
    Authors:
    Paulina Kasperkiewicz, Marcin Poreba, Scott J. Snipas, S. Jack Lin, Daniel Kirchhofer, Guy S. Salvesen, Marcin Drag
    Academic press:
    Plos ONE (rok: 2015, tom: N/A, strony: 45303), Wydawca: PLOS
    Status:
    Published
    DOI:
    10.1371/journal.pone.0132818 - link to the publication
  2. Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families.
    Authors:
    Poreba M, Szalek A, Rut W, Kasperkiewicz P, Rutkowska-Wlodarczyk I, Snipas SJ, Itoh Y, Turk D, Turk B, Overall CM, Kaczmarek L, Salvesen GS, Drąg M
    Academic press:
    Scientific Reports (rok: 2017, tom: 7, strony: 1-13 43135), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/srep43135 - link to the publication
  3. Toolbox of Fluorescent Probes for Parallel Imaging Reveals Uneven Location of Serine Proteases in Neutrophils
    Authors:
    Paulina Kasperkiewicz, Yoav Altman, Maximiliano D'Angelo, Guy S. Salvesen, Marcin Drag
    Academic press:
    Journal of the American Chemical Society (rok: 2017, tom: 139, strony: 10115-10125), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/jacs.7b04394 - link to the publication
  4. Emerging challenges in the design of selective substrates, inhibitors and activity-based probes for indistinguishable proteases.
    Authors:
    Kasperkiewicz Paulina, Poręba Marcin, Groborz Katarzyna, Drąg Marcin
    Academic press:
    FEBS Journal (rok: 2017, tom: 10, strony: 1518-1539), Wydawca: WILEY-BLACKWELL
    Status:
    Published
    DOI:
    10.1111/febs.14001. - link to the publication
  5. Synthesis of a HyCoSuL peptide substrate library to dissect protease substrate specificity
    Authors:
    Marcin Poreba, Guy S Salvesen & Marcin Drag
    Academic press:
    Nature Protocols (rok: 2017, tom: vol.12, no.10, strony: 2189-2214), Wydawca: Macmillan Publishers Limited, part of Springer Nature.
    Status:
    Published
    DOI:
    10.1038/nprot.2017.091 - link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy