Selective activity based probes for imaging of active serine proteases in neutrophils.
2014/14/M/ST5/00619
Keywords
Descriptors
- ST5_16: Chemia biologiczna
- ST5_23: Chemia organiczna
Panel
ST5 – Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering
Host institution
Politechnika Wrocławska, Wydział Chemiczny
Voivodeship: dolnośląskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 5
Call
HARMONIA 6 – announced on 2014-06-16
- Amount awarded
- 1 030 880 PLN
- Project start date
- 2015-05-25
- Project end date
- 2018-05-24
- Project duration
- 36 months (the same as in the proposal)
- Project status
- Project settled
Information in the final report
Publication in academic press/journals (5)
-
Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families.
- Authors:
- Poreba M, Szalek A, Rut W, Kasperkiewicz P, Rutkowska-Wlodarczyk I, Snipas SJ, Itoh Y, Turk D, Turk B, Overall CM, Kaczmarek L, Salvesen GS, Drąg M
- Academic press:
- Scientific Reports (year: 2017, volume: 7, pages: 1-13 43135), Publisher: Nature Publishing Group
- Status:
- Published
- DOI:
- 10.1038/srep43135 – link to the publication
-
Emerging challenges in the design of selective substrates, inhibitors and activity-based probes for indistinguishable proteases.
- Authors:
- Kasperkiewicz Paulina, Poręba Marcin, Groborz Katarzyna, Drąg Marcin
- Academic press:
- FEBS Journal (year: 2017, volume: 10, pages: 1518-1539), Publisher: WILEY-BLACKWELL
- Status:
- Published
- DOI:
- 10.1111/febs.14001. – link to the publication
-
Design of a Selective Substrate and Activity Based Probe for Human Neutrophil Serine Protease 4
- Authors:
- Paulina Kasperkiewicz, Marcin Poreba, Scott J. Snipas, S. Jack Lin, Daniel Kirchhofer, Guy S. Salvesen, Marcin Drag
- Academic press:
- Plos ONE (year: 2015, volume: N/A, pages: 46034), Publisher: PLOS
- Status:
- Published
- DOI:
- 10.1371/journal.pone.0132818 – link to the publication
-
Synthesis of a HyCoSuL peptide substrate library to dissect protease substrate specificity
- Authors:
- Marcin Poreba, Guy S Salvesen & Marcin Drag
- Academic press:
- Nature Protocols (year: 2017, volume: vol.12, no.10, pages: 2189-2214), Publisher: Macmillan Publishers Limited, part of Springer Nature.
- Status:
- Published
- DOI:
- 10.1038/nprot.2017.091 – link to the publication
-
Toolbox of Fluorescent Probes for Parallel Imaging Reveals Uneven Location of Serine Proteases in Neutrophils
- Authors:
- Paulina Kasperkiewicz, Yoav Altman, Maximiliano D'Angelo, Guy S. Salvesen, Marcin Drag
- Academic press:
- Journal of the American Chemical Society (year: 2017, volume: 139, pages: 10115-10125), Publisher: American Chemical Society
- Status:
- Published
- DOI:
- 10.1021/jacs.7b04394 – link to the publication