Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The role of the HtrA protein in the Helicobacter pylori cell

2016/21/B/NZ2/01775

Keywords:

human pathogen H. pylori protease/chaperone HtrA the role in survival of bacterial cell suppressor mutations identification of natural substrates transcryptomics proteomics

Descriptors:

  • NZ2_2: Genomics, transcriptomics, epigenomics
  • NZ2_3: Proteomics
  • NZ2_9: Systems biology

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Uniwersytet Gdański, Wydział Biologii

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Joanna Skórko-Glonek 

Number of co-investigators in the project: 5

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 851 300 PLN

Project start date (Y-m-d): 2017-02-27

Project end date (Y-m-d): 2021-08-26

Project duration:: 54 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komora do jałowej pracy.
  2. Mini-wirówka laboratoryjna.
  3. Spektrofotometr Vis.
  4. System dokumentacji żeli i blotów (160 000 PLN)
  5. System do hodowli bakterii w warunkach o regulowanym stężeniu tlenu (40 000 PLN)
  6. Program do analizy dwukierunkowych elektroforegramów, wliczając DIGE (65 000 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  1. Establishment of serine protease htrA mutants in Helicobacter pylori is associated with secA mutations
    Authors:
    Zawilak-Pawlik A, Zarzecka U, Żyła-Uklejewicz D, Lach J, Strapagiel D, Tegtmeyer N, Böhm M, Backert S, Skorko-Glonek J.
    Academic press:
    Scientific Reports (rok: 2019, tom: 9, strony: Article Number: 11794), Wydawca: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
    Status:
    Published
    DOI:
    10.1038/s41598-019-48030-6 - link to the publication
  2. Extracellular HtrA serine proteases: An emerging new strategy in bacterial pathogenesis.
    Authors:
    Backert S, Bernegger S, Skórko-Glonek J, Wessler S
    Academic press:
    Cellular Microbiology (rok: 2018, tom: 20(6):e12845, strony: nie dotyczy), Wydawca: John Wiley & Sons Ltd
    Status:
    Published
    DOI:
    10.1111/cmi.12845 - link to the publication
  3. Chaperone activity of serine protease HtrA of Helicobacter pylori as a crucial survival factor under stress conditions.
    Authors:
    Zarzecka U, Harrer A, Zawilak-Pawlik A, Skorko-Glonek J, Backert S.
    Academic press:
    Cell Communication and Signaling (rok: 2019, tom: Vol:17 Iss:1, strony: 161), Wydawca: BioMed Central Ltd. Part of Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12964-019-0481-9 - link to the publication
  4. Functional analysis and cryo-electron microscopy of Campylobacter jejuni serine protease HtrA
    Authors:
    16)Zarzecka, U., Grinzato, A., Kandiah, E., Cysewski, D., Berto, P., Skorko-Glonek, J., Zanotti, G., Backert, S
    Academic press:
    Gut Microbes (rok: 2020, tom: Vol. ‏ 12, strony: Article: 1810532), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/19490976.2020.1810532 - link to the publication
  5. Importance of two PDZ domains for the proteolytic and chaperone activities of Helicobacter pylori serine protease HtrA
    Authors:
    17)Zarzecka, U., Matkowska, D., Backert, S., Skorko-Glonek, J
    Academic press:
    Cellular Microbiology (rok: 2021, tom: Vol. 23, Issue4, strony: article Number: e13299), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/cmi.13299 - link to the publication
  6. Properties of the HtrA Protease From Bacterium Helicobacter pylori Whose Activity Is Indispensable for Growth Under Stress Conditions
    Authors:
    Zarzecka U, Modrak-Wójcik A, Figaj D, Apanowicz M, Lesner A, Bzowska A, Lipinska B, Zawilak-Pawlik A, Backert S, Skorko-Glonek J.
    Academic press:
    Frontiers in Microbiology (rok: 2019, tom: 10, strony: Article no. 961), Wydawca: FRONTIERS MEDIA SA, AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
    Status:
    Published
    DOI:
    10.3389/fmicb.2019.00961 - link to the publication

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