Searching of new compounds with anti-inflammatory activity from Oleaceae family plants growing in Poland conducted using in vitro and in vivo models followed by molecular mechanism determination
2015/17/B/NZ7/03086
Keywords
- Oleaceae
- forsythia
- lilac
- ash
- irydoids
- phenylethanoids
- lignans
- coumarins
- HPLC-MS/MS analysis
- bio-guided fractionation
- anti-inflammatory activity
- resolution of inflammation
- neutrophils
- macrophages
- monocytes
- lymphocytes
- oxidative burst
- cytokines
- proteases
- apoptosis
- phagocytosis
- signaling pathways
- transcription factor NF-κB
Descriptors
- NZ7_14: Farmacja, farmakoterapia, farmakologia
Panel
NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution
Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej
Voivodeship: mazowieckie
Principal investigator (from the host institution)
Number of co-investigators in the project: 10
Call
OPUS 9 – announced on 2015-03-16
- Amount awarded
- 866 000 PLN
- Project start date
- 2016-02-03
- Project end date
- 2019-08-02
- Project duration
- 42 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- Blok grzewczy do odparowania próbek. Cost: 30 000 PLN
- Chromatograf cieczowy preparatywny (z detektorem UV-Vis, autosamplered, oprogramowaniem). Cost: 200 000 PLN
Information in the final report
Publication in academic press/journals (5)
-
Effects of Phytochemically Characterized Extracts from Syringa vulgaris and Isolated Secoiridoids on Mediators of Inflammation in a Human Neutrophil Model
- Authors:
- Marta Woźniak, Barbara Michalak, Joanna Wyszomierska, Marta K. Dudek, Anna K. Kiss
- Academic press:
- Frontiers in Pharmacology (year: 2018, volume: 9, pages: 349 (1-15)), Publisher: Frontiers Media
- Status:
- Published
- DOI:
- 10.3389/fphar.2018.00349. – link to the publication
-
Hydroxycinnamoyl derivatives and secoiridoid glycoside derivatives from Syringa vulgaris flowers and their effects on the pro-inflammatory responses of human neutrophils
- Authors:
- M.K. Dudek, B. Michalak, M. Woźniak, M.E. Czerwińska, A. Filipek, S. Granica, A.K. Kiss
- Academic press:
- Fitoterapia (year: 2017, volume: 121, pages: 194-205), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.fitote.2017.07.008 – link to the publication
-
Lignans from Forsythia x intermedia leaves and flowers attenuate the pro-inflammatory function of leukocytes and their interaction with endothelial cells.
- Authors:
- Barbara Michalak, Agnieszka Filipek, Piotr Chomicki, Małgorzata Pyza, Marta Wożniak, Barbara Żyżyńska‐Granica, Jakub P. Piwowarski, Agnieszka Kicel, Monika A. Olszewska, Anna K. Kiss
- Academic press:
- Frontiers in Pharmacology (year: 2018, volume: 9, pages: 401 (1-17)), Publisher: Frontiers Media
- Status:
- Published
- DOI:
- 10.3389/fphar.2018.00401 – link to the publication
-
Syringa vulgaris bark as a source of compounds affecting the release of mediators of inflammation from human neutrophils and monocytes/macrophages.
- Authors:
- Agnieszka Filipek, Joanna Wyszomierska, Barbara Michalak, Anna K. Kiss
- Academic press:
- Phytochemistry Letters (year: 2019, volume: 30, pages: 309-313), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.phytol.2019.02.008 – link to the publication
-
UHPLC‐DAD‐ESI‐MS/MS and HPTLC profiling of ash leaf samples from different commercial and natural sources and their in vitro effects on mediators of inflammation
- Authors:
- Anna K. Kiss, Barbara Michalak, Andrzej Patyra,Magdalena Majdan
- Academic press:
- Phytochemical Analysis (year: 2020, volume: 31, pages: 57-67), Publisher: Wiley
- Status:
- Published
- DOI:
- 10.1002/pca.2866 – link to the publication