Projects funded by the NCN


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174 projects found matching your search criteria :

  1. The role of sirtuins and AMPK protein kinase in insulin resistance of podocytes

    Call: OPUS 3 , Panel: NZ5

    Principal investigator: dr Dorota Rogacka

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

  2. Czy hiperaktywacja kinazy mTOR prowadzi do zaburzeń różnicowania komórek nerwowych?

    Call: FUGA 1 , Panel: NZ3

    Principal investigator: dr Bartosz Michał Tarkowski

    Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie

  3. An attempt to elucidate the role of clusterin and lipid rafts in Alzheimer's disease etiology.

    Call: OPUS 2 , Panel: NZ7

    Principal investigator: prof. Arkadiusz Bernard Orzechowski

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

  4. PIM kinases as rational therapeutic targets in lymphoid malignancies.

    Call: OPUS 2 , Panel: NZ4

    Principal investigator: dr hab. Przemysław Juszczyński

    Instytut Hematologii i Transfuzjologii

  5. The role of SnRK2 kinases in plant response to environmental stresses. The interplay between SnRK2 kinases, PP2C phospha...

    Call: OPUS 2 , Panel: NZ3

    Principal investigator: prof. Grażyna Anna Dobrowolska

    Instytut Biochemii i Biofizyki Polskiej Akademii Nauk

  6. Investigation of histidine phosphorylation in thymidylate synthase and searching for causative protein kinase

    Call: OPUS 2 , Panel: NZ1

    Principal investigator: dr hab. Joanna Cieśla

    Politechnika Warszawska

  7. Analysis of pharmacokinetic, pharmacodynamic and molecular determinants of intolerance and resistance to the Janus kinas...

    Call: OPUS 27 , Panel: NZ7

    Principal investigator: dr hab. Marta Katarzyna Karaźniewicz-Łada

    Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

  8. Mechanisms of Antidepressant Action of Psilocybin: The Role of 5-HT2B-5-HT1A Receptor Dimerization and GSK-3β Activation...

    Call: OPUS 27 , Panel: NZ7

    Principal investigator: dr hab. Agata Faron-Górecka

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  9. Regulatory role of the N-terminal fragment of diacylglycerol kinase-ε and its contribution to the pro-inflammatory respo...

    Call: PRELUDIUM 23 , Panel: NZ3

    Principal investigator: Gabriela Traczyk

    Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

  10. Precision double strike against non-small cell lung cancer. Insights into multidirectional therapies and the landscape o...

    Call: OPUS 27 , Panel: NZ5

    Principal investigator: dr Katarzyna Anna Malarz

    Politechnika Śląska

  11. Selective inhibition of Janus kinases for the treatment of autoimmune hepatitis: Translational PK/PD modelling from mole...

    Call: SONATA 19 , Panel: NZ7

    Principal investigator: dr Artur Świerczek

    Uniwersytet Jagielloński, Collegium Medicum

  12. Zn2+-dependent competition between CD4 and CD8α coreceprtor for Lck tyrosine kinase

    Call: SONATA 19 , Panel: NZ1

    Principal investigator: dr Anna Marta Kocyła

    Uniwersytet Wrocławski, Wydział Biotechnologii

  13. Deciphering the importance of the intracellular FGFR1 module for cell fate

    Call: OPUS 26 , Panel: NZ1

    Principal investigator: dr hab. Małgorzata Urszula Zakrzewska

    Uniwersytet Wrocławski, Wydział Biotechnologii

  14. First-in-class dual modulators of necroptosis kinases and 5-HT6 receptors as an innovative approach to develop an effect...

    Call: OPUS 26 , Panel: NZ7

    Principal investigator: prof. Jadwiga Handzlik

    Uniwersytet Jagielloński, Collegium Medicum

  15. Targeting adenylate kinase 4 (AK4) as a new paradigm in the treatment of non-small cell lung cancer: discovery and evalu...

    Call: OPUS 26 , Panel: NZ7

    Principal investigator: dr Magdalena Wujak

    Uniwersytet Mikołaja Kopernika w Toruniu, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy

  16. Regulation of clathrin-dependent endocytosis by mTOR kinase in neuronal development

    Call: OPUS 2 , Panel: NZ3

    Principal investigator: prof. Jacek Ryszard Jaworski

    Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie

  17. Novel aspects of the mechanisms of vascular toxicity of tyrosine kinase inhibitors: studies on their proinflammatory act...

    Call: OPUS 26 , Panel: NZ5

    Principal investigator: dr Tomasz Krzysztof Prajsnar

    Uniwersytet Jagielloński, Wydział Biologii

  18. Exploring kinase hyperactivation as an innovative approach for chemo-immunotherapy for B cell acute lymphoblastic leukem...

    Call: PRELUDIUM BIS 5 , Panel: NZ7

    Principal investigator: dr hab. Małgorzata Firczuk

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

  19. Molecular mechanisms of DNA damage triggered by PIM kinases inhibition and its consequences for activation of innate imm...

    Call: OPUS 25 , Panel: NZ5

    Principal investigator: prof. Przemysław Juszczyński

    Instytut Hematologii i Transfuzjologii

  20. Investigating the mechanisms of CD20 downregulation triggered by tyrosine kinase inhibitors in Philadelphia chromosome-p...

    Call: PRELUDIUM 22 , Panel: NZ5

    Principal investigator: Krzysztof Domka

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

  21. Regulacja procesu deoksyhypuzynacji przez kinazy białkowe

    Call: PRELUDIUM 22 , Panel: NZ1

    Principal investigator: Paweł Kochanowski

    Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

  22. Search for novel IKK-β inhibitors in the context of diseases with neuroinflammatory origin – structure-based drug design...

    Call: PRELUDIUM 22 , Panel: NZ7

    Principal investigator: Emilia Aleksandra Sługocka

    Uniwersytet Jagielloński, Collegium Medicum

  23. INVADOPODIA IN AXL-DRIVEN CANCER INVASION AND DRUG RESISTANCE

    Call: OPUS 25 , Panel: NZ3

    Principal investigator: dr Daria Paulina Zdżalik-Bielecka

    Uniwersytet Warszawski, Wydział Biologii

  24. Targeting Energy Metabolism for Precision Cancer Therapy: Novel Inhibitors of LDH-A and PDK1 as Potential Strategies to ...

    Call: PRELUDIUM 22 , Panel: NZ7

    Principal investigator: Marika Anna Frańczak

    Gdański Uniwersytet Medyczny, Wydział Lekarski

  25. The potassium puzzle: unraveling the connection between the potassium channel and lipid kinases in kidney functioning

    Call: OPUS 25 , Panel: NZ1

    Principal investigator: dr hab. Piotr Rajmund Koprowski

    Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

  26. The effect of PKC epsilon modification on autophagy in cancer cells.

    Call: OPUS 2 , Panel: NZ7

    Principal investigator: prof. Maria Jolenta Rybczyńska

    Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Farmaceutyczny

  27. Dissecting the regulatory interplay between proteases and protein kinases in acute lymphoblastic leukemia using mass cyt...

    Call: OPUS 24 , Panel: NZ5

    Principal investigator: dr hab. Marcin Łukasz Poręba

    Politechnika Wrocławska

  28. Effects of tyrosine kinase inhibitors on Syk pathway in eNOS-based platelet subpopulations and on endothelial barrier in...

    Call: POLONEZ BIS 3 , Panel: NZ7

    Principal investigator: dr hab. Aneta Iwona Radziwon-Balicka

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  29. A double whammy for the NF-κB signalling pathway: development of TAK1 and IKKβ degraders against inflammation-driven dis...

    Call: OPUS 24 (LAP) , Panel: NZ7

    Principal investigator: dr hab. Anna Karolina Więckowska

    Uniwersytet Jagielloński, Collegium Medicum

  30. Thermodynamic contribution of halogen bonds in protein-ligand systems. Design, synthesis, and thermodynamic studies of m...

    Call: PRELUDIUM 21 , Panel: ST4

    Principal investigator: dr Sławomir Jan Kasperowicz

    Instytut Biochemii i Biofizyki Polskiej Akademii Nauk

  31. Smart tissue engineering to change the paradigm of diabetes treatment

    Call: OPUS 23 , Panel: NZ7

    Principal investigator: dr Anna Czarna

    Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

  32. Unraveling mechanisms and physiological outcome of lipid-evoked regulation of proteostasis in the intestine.

    Call: OPUS 23 , Panel: NZ4

    Principal investigator: dr hab. Grzegorz Piotr Sumara

    Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

  33. The SnRK2 kinases as key proteins in seeds biology- unraveling new molecular mechanisms determining seed germination abi...

    Call: OPUS 23 , Panel: NZ3

    Principal investigator: dr Anna Marta Kulik

    Instytut Biochemii i Biofizyki Polskiej Akademii Nauk

  34. Analysis of molecular background of clear cell renal cell carcinoma and role of MCPIP1 in tomorigenesis

    Call: OPUS 2 , Panel: NZ1

    Principal investigator: prof. Jolanta Jura

    Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

  35. Role of RelA(p65) and cRel phosphorylations and their kinases in the biology of Diffuse-large B-cell lymphoma and Hodgki...

    Call: OPUS 22 , Panel: NZ5

    Principal investigator: dr Maciej Stefan Szydłowski

    Instytut Hematologii i Transfuzjologii

  36. Novel broad-spectrum central nervous system active substances: optimization of their multi-target profile

    Call: OPUS 22 , Panel: NZ7

    Principal investigator: dr hab. Agnieszka Anna Kaczor

    Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny

  37. Small-molecule inhibitors of protein aggregation and ER stress as a novel strategy against neurodegeneration in the cour...

    Call: PRELUDIUM BIS 3 , Panel: NZ5

    Principal investigator: prof. Ireneusz Jacek Majsterek

    Uniwersytet Medyczny w Łodzi

  38. New strategies in the treatment of non-small cell lung cancer based on silk nanocarriers targeting tumor vascularization

    Call: SONATA 17 , Panel: NZ7

    Principal investigator: dr Anna Katarzyna Florczak-Substyk

    Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

  39. Research of multifunctional compounds targeting neuroinflammation and cholinergic deficit in Alzheimer's disease

    Call: OPUS 22 (LAP) , Panel: NZ7

    Principal investigator: prof. Kinga Aleksandra Sałat

    Uniwersytet Jagielloński, Collegium Medicum

  40. Investigation of the MLK4 biology in breast cancer and search for new therapeutic strategies using innovative PROTAC com...

    Call: SONATA BIS 11 , Panel: NZ5

    Principal investigator: dr Anna Agnieszka Marusiak

    Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk

  41. RE-SENSE: Dual-loaded lipid nanoparticles to overcome the resistance of non-small cell lung cancer cells to personalized...

    Call: PRELUDIUM 20 , Panel: NZ7

    Principal investigator: Mikołaj Czajkowski

    Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

  42. Expression, regulation and function of super-enhancer non-coding RNAs in Diffuse Large B-Cell Lymphoma (DLBCL)

    Call: PRELUDIUM 20 , Panel: NZ5

    Principal investigator: dr Sonia Maria Dębek

    Instytut Hematologii i Transfuzjologii

  43. Investigating the role of the focal adhesion kinase and its related signaling pathways in glucocorticoid- and stress-ind...

    Call: PRELUDIUM 20 , Panel: NZ4

    Principal investigator: Michał Józef Wilczkowski

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  44. MLK4 signaling in DNA damage response and cancer therapy

    Call: PRELUDIUM 20 , Panel: NZ3

    Principal investigator: Dawid Grzegorz Mehlich

    Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk

  45. AXL receptor signaling in cancer cell growth and drug resistance

    Call: OPUS 20 , Panel: NZ3

    Principal investigator: prof. Marta Elżbieta Miączyńska

    Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie

  46. Iron chelators as tyrosine kinase inhibitors - a new strategy for the treatment of glioblastoma multiforme

    Call: PRELUDIUM BIS 2 , Panel: NZ5

    Principal investigator: dr hab. Anna Dominika Mrozek-Wilczkiewicz

    Uniwersytet Śląski w Katowicach, Wydział Nauk Ścisłych i Technicznych

  47. Cell-based high-throughput screening for small-molecule compounds diminishing molecular markers of pathogenesis in myoto...

    Call: OPUS 20 , Panel: NZ3

    Principal investigator: dr hab. Marzena Wojciechowska

    Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

  48. A novel approach based on the optimized multidrug combination for glioblastoma treatment.

    Call: SONATA 16 , Panel: NZ7

    Principal investigator: prof. Małgorzata Kucińska

    Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

  49. FAST interactions in cell death regulation

    Call: PRELUDIUM 19 , Panel: NZ1

    Principal investigator: Daria Martyna Dawidziak

    Uniwersytet Warszawski, Wydział Chemii

  50. OMENTIN1 as a new regulator of female reproduction - expression and role in the pituitary - ovary axis. Study on swine m...

    Call: OPUS 19 , Panel: NZ9

    Principal investigator: dr hab. Agnieszka Małgorzata Rak

    Uniwersytet Jagielloński, Wydział Biologii