Projects funded by the NCN

The role of sirtuins and AMPK protein kinase in insulin resistance of podocytes

Call: OPUS 3 , Panel: NZ5

Principal investigator: dr Dorota Rogacka

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Czy hiperaktywacja kinazy mTOR prowadzi do zaburzeń różnicowania komórek nerwowych?

Call: FUGA 1 , Panel: NZ3

Principal investigator: dr Bartosz Michał Tarkowski

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

An attempt to elucidate the role of clusterin and lipid rafts in Alzheimer's disease etiology.

Call: OPUS 2 , Panel: NZ7

Principal investigator: prof. Arkadiusz Bernard Orzechowski

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

PIM kinases as rational therapeutic targets in lymphoid malignancies.

Call: OPUS 2 , Panel: NZ4

Principal investigator: dr hab. Przemysław Juszczyński

Instytut Hematologii i Transfuzjologii

The role of SnRK2 kinases in plant response to environmental stresses. The interplay between SnRK2 kinases, PP2C phospha...

Call: OPUS 2 , Panel: NZ3

Principal investigator: prof. Grażyna Anna Dobrowolska

Instytut Biochemii i Biofizyki PAN

Phosphorylation-Dependent Regulation of IRS2 by DYRK1A: Implications for Diabetes Therapy

Call: PRELUDIUM 24 , Panel: NZ1

Principal investigator: Alicja Bis

Uniwersytet Jagielloński

Identification of the regulon and interactome of orphan histidine kinase in Streptomyces coelicolor A3(2)

Call: PRELUDIUM 24 , Panel: NZ2

Principal investigator: Mateusz Wenecki

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

Graphene Oxide-Immobilized Adenylate Kinase as a Molecular Mediator of Vascular Homeostasis

Call: PRELUDIUM 24 , Panel: NZ1

Principal investigator: Agata Wikarska

Uniwersytet Mikołaja Kopernika

Analysis of pharmacokinetic, pharmacodynamic and molecular determinants of intolerance and resistance to the Janus kinas...

Call: OPUS 27 , Panel: NZ7

Principal investigator: dr hab. Marta Katarzyna Karaźniewicz-Łada

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Investigation of histidine phosphorylation in thymidylate synthase and searching for causative protein kinase

Call: OPUS 2 , Panel: NZ1

Principal investigator: dr hab. Joanna Cieśla

Politechnika Warszawska

Mechanisms of Antidepressant Action of Psilocybin: The Role of 5-HT2B-5-HT1A Receptor Dimerization and GSK-3β Activation...

Call: OPUS 27 , Panel: NZ7

Principal investigator: dr hab. Agata Faron-Górecka

Instytut Farmakologii PAN

Regulatory role of the N-terminal fragment of diacylglycerol kinase-ε and its contribution to the pro-inflammatory respo...

Call: PRELUDIUM 23 , Panel: NZ3

Principal investigator: Gabriela Traczyk

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Precision double strike against non-small cell lung cancer. Insights into multidirectional therapies and the landscape o...

Call: OPUS 27 , Panel: NZ5

Principal investigator: dr Katarzyna Anna Malarz

Politechnika Śląska

Selective inhibition of Janus kinases for the treatment of autoimmune hepatitis: Translational PK/PD modelling from mole...

Call: SONATA 19 , Panel: NZ7

Principal investigator: dr Artur Świerczek

Uniwersytet Jagielloński, Collegium Medicum

Zn2+-dependent competition between CD4 and CD8α coreceprtor for Lck tyrosine kinase

Call: SONATA 19 , Panel: NZ1

Principal investigator: dr Anna Marta Kocyła

Uniwersytet Wrocławski, Wydział Biotechnologii

Deciphering the importance of the intracellular FGFR1 module for cell fate

Call: OPUS 26 , Panel: NZ1

Principal investigator: dr hab. Małgorzata Urszula Zakrzewska

Uniwersytet Wrocławski, Wydział Biotechnologii

First-in-class dual modulators of necroptosis kinases and 5-HT6 receptors as an innovative approach to develop an effect...

Call: OPUS 26 , Panel: NZ7

Principal investigator: prof. Jadwiga Handzlik

Uniwersytet Jagielloński, Collegium Medicum

Targeting adenylate kinase 4 (AK4) as a new paradigm in the treatment of non-small cell lung cancer: discovery and evalu...

Call: OPUS 26 , Panel: NZ7

Principal investigator: dr Magdalena Wujak

Uniwersytet Mikołaja Kopernika, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy

Regulation of clathrin-dependent endocytosis by mTOR kinase in neuronal development

Call: OPUS 2 , Panel: NZ3

Principal investigator: prof. Jacek Ryszard Jaworski

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

Novel aspects of the mechanisms of vascular toxicity of tyrosine kinase inhibitors: studies on their proinflammatory act...

Call: OPUS 26 , Panel: NZ5

Principal investigator: dr Tomasz Krzysztof Prajsnar

Uniwersytet Jagielloński, Wydział Biologii

Exploring kinase hyperactivation as an innovative approach for chemo-immunotherapy for B cell acute lymphoblastic leukem...

Call: PRELUDIUM BIS 5 , Panel: NZ7

Principal investigator: dr hab. Małgorzata Firczuk

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Molecular mechanisms of DNA damage triggered by PIM kinases inhibition and its consequences for activation of innate imm...

Call: OPUS 25 , Panel: NZ5

Principal investigator: prof. Przemysław Juszczyński

Instytut Hematologii i Transfuzjologii

Investigating the mechanisms of CD20 downregulation triggered by tyrosine kinase inhibitors in Philadelphia chromosome-p...

Call: PRELUDIUM 22 , Panel: NZ5

Principal investigator: Krzysztof Domka

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Regulacja procesu deoksyhypuzynacji przez kinazy białkowe

Call: PRELUDIUM 22 , Panel: NZ1

Principal investigator: Paweł Kochanowski

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

Search for novel IKK-β inhibitors in the context of diseases with neuroinflammatory origin – structure-based drug design...

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Emilia Aleksandra Sługocka

Uniwersytet Jagielloński, Collegium Medicum

INVADOPODIA IN AXL-DRIVEN CANCER INVASION AND DRUG RESISTANCE

Call: OPUS 25 , Panel: NZ3

Principal investigator: dr Daria Paulina Zdżalik-Bielecka

Uniwersytet Warszawski, Wydział Biologii

Targeting Energy Metabolism for Precision Cancer Therapy: Novel Inhibitors of LDH-A and PDK1 as Potential Strategies to ...

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Marika Anna Frańczak

Gdański Uniwersytet Medyczny, Wydział Lekarski

The potassium puzzle: unraveling the connection between the potassium channel and lipid kinases in kidney functioning

Call: OPUS 25 , Panel: NZ1

Principal investigator: dr hab. Piotr Rajmund Koprowski

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

The effect of PKC epsilon modification on autophagy in cancer cells.

Call: OPUS 2 , Panel: NZ7

Principal investigator: prof. Maria Jolenta Rybczyńska

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Farmaceutyczny

Dissecting the regulatory interplay between proteases and protein kinases in acute lymphoblastic leukemia using mass cyt...

Call: OPUS 24 , Panel: NZ5

Principal investigator: dr hab. Marcin Łukasz Poręba

Politechnika Wrocławska

Effects of tyrosine kinase inhibitors on Syk pathway in eNOS-based platelet subpopulations and on endothelial barrier in...

Call: POLONEZ BIS 3 , Panel: NZ7

Principal investigator: dr hab. Aneta Iwona Radziwon-Balicka

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

A double whammy for the NF-κB signalling pathway: development of TAK1 and IKKβ degraders against inflammation-driven dis...

Call: OPUS 24 (LAP) , Panel: NZ7

Principal investigator: dr hab. Anna Karolina Więckowska

Uniwersytet Jagielloński, Collegium Medicum

Thermodynamic contribution of halogen bonds in protein-ligand systems. Design, synthesis, and thermodynamic studies of m...

Call: PRELUDIUM 21 , Panel: ST4

Principal investigator: dr Sławomir Jan Kasperowicz

Instytut Biochemii i Biofizyki PAN

Smart tissue engineering to change the paradigm of diabetes treatment

Call: OPUS 23 , Panel: NZ7

Principal investigator: dr Anna Czarna

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

Unraveling mechanisms and physiological outcome of lipid-evoked regulation of proteostasis in the intestine.

Call: OPUS 23 , Panel: NZ4

Principal investigator: dr hab. Grzegorz Piotr Sumara

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

The SnRK2 kinases as key proteins in seeds biology- unraveling new molecular mechanisms determining seed germination abi...

Call: OPUS 23 , Panel: NZ3

Principal investigator: dr Anna Marta Kulik

Instytut Biochemii i Biofizyki PAN

Analysis of molecular background of clear cell renal cell carcinoma and role of MCPIP1 in tomorigenesis

Call: OPUS 2 , Panel: NZ1

Principal investigator: prof. Jolanta Jura

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Role of RelA(p65) and cRel phosphorylations and their kinases in the biology of Diffuse-large B-cell lymphoma and Hodgki...

Call: OPUS 22 , Panel: NZ5

Principal investigator: dr Maciej Stefan Szydłowski

Instytut Hematologii i Transfuzjologii

Novel broad-spectrum central nervous system active substances: optimization of their multi-target profile

Call: OPUS 22 , Panel: NZ7

Principal investigator: dr hab. Agnieszka Anna Kaczor

Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny

Small-molecule inhibitors of protein aggregation and ER stress as a novel strategy against neurodegeneration in the cour...

Call: PRELUDIUM BIS 3 , Panel: NZ5

Principal investigator: prof. Ireneusz Jacek Majsterek

Uniwersytet Medyczny w Łodzi

New strategies in the treatment of non-small cell lung cancer based on silk nanocarriers targeting tumor vascularization

Call: SONATA 17 , Panel: NZ7

Principal investigator: dr Anna Katarzyna Florczak-Substyk

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Research of multifunctional compounds targeting neuroinflammation and cholinergic deficit in Alzheimer's disease

Call: OPUS 22 (LAP) , Panel: NZ7

Principal investigator: prof. Kinga Aleksandra Sałat

Uniwersytet Jagielloński, Collegium Medicum

Investigation of the MLK4 biology in breast cancer and search for new therapeutic strategies using innovative PROTAC com...

Call: SONATA BIS 11 , Panel: NZ5

Principal investigator: dr Anna Agnieszka Marusiak

Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk

RE-SENSE: Dual-loaded lipid nanoparticles to overcome the resistance of non-small cell lung cancer cells to personalized...

Call: PRELUDIUM 20 , Panel: NZ7

Principal investigator: Mikołaj Czajkowski

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Expression, regulation and function of super-enhancer non-coding RNAs in Diffuse Large B-Cell Lymphoma (DLBCL)

Call: PRELUDIUM 20 , Panel: NZ5

Principal investigator: dr Sonia Maria Dębek

Instytut Hematologii i Transfuzjologii

Investigating the role of the focal adhesion kinase and its related signaling pathways in glucocorticoid- and stress-ind...

Call: PRELUDIUM 20 , Panel: NZ4

Principal investigator: Michał Józef Wilczkowski

Instytut Farmakologii PAN

MLK4 signaling in DNA damage response and cancer therapy

Call: PRELUDIUM 20 , Panel: NZ3

Principal investigator: Dawid Grzegorz Mehlich

Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk

AXL receptor signaling in cancer cell growth and drug resistance

Call: OPUS 20 , Panel: NZ3

Principal investigator: prof. Marta Elżbieta Miączyńska

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

Iron chelators as tyrosine kinase inhibitors - a new strategy for the treatment of glioblastoma multiforme

Call: PRELUDIUM BIS 2 , Panel: NZ5

Principal investigator: dr hab. Anna Dominika Mrozek-Wilczkiewicz

UNIWERSYTET ŚLĄSKI, Wydział Nauk Ścisłych i Technicznych

Cell-based high-throughput screening for small-molecule compounds diminishing molecular markers of pathogenesis in myoto...

Call: OPUS 20 , Panel: NZ3

Principal investigator: dr hab. Marzena Wojciechowska

Instytut Chemii Bioorganicznej PAN