Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Protein kinase B signalling pathway in glioblastoma cells transfected with sequence encoding liver-type glutaminase (GAB)

2016/23/N/NZ5/01428

Keywords:

glioblastoma protein kinase B liver-type glutaminase

Descriptors:

  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Ewelina Majewska 

Number of co-investigators in the project: 2

Call: PRELUDIUM 12 - announced on 2016-09-15

Amount awarded: 99 950 PLN

Project start date (Y-m-d): 2017-08-04

Project end date (Y-m-d): 2019-08-03

Project duration:: 24 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (1)
  • Articles in post-conference publications (2)
  1. Transfection with GLS2 Glutaminase (GAB) Sensitizes Human Glioblastoma Cell Lines to Oxidative Stress by a Common Mechanism Involving Suppression of the PI3K/AKT Pathway
    Authors:
    Ewelina Majewska, Javier Márquez, Jan Albrecht, Monika Szeliga
    Academic press:
    Cancers (rok: 2019, tom: 11, strony: 45309), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers11010115 - link to the publication
  1. Transfection with liver-type glutaminase (GAB) enhances sensitivity of human glioblastoma cell lines to hydrogen peroxide-induced oxidative stress
    Authors:
    Ewelina Majewska, Monika Szeliga, Javier Marquez, Jan Albrecht
    Conference:
    Neurochemical Conference 2017: Advances in molecular and epigenetic mechanisms in neurodegeneration and neuroinflammation: novel therapeutic approaches" (rok: 2017, ), Wydawca: Folia Neuropathologica
    Data:
    konferencja 19.10-20.10
    Status:
    Published
  2. Transfection with liver-type glutaminase (GAB) sensitises human glioblastoma cell lines to hydrogen peroxide by downregulation of the PI3K/AKT pathway
    Authors:
    Ewelina Majewska, Javier Marquez, Jan Albrecht, Monika Szeliga
    Conference:
    European Association for Cancer Research (EACR25) (rok: 2018, ), Wydawca: ESMO Open Cancer Horizons
    Data:
    konferencja 30.06-3.07
    Status:
    Published

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