Projects funded by the NCN
Therapeutic potential of biased 5-HT7 receptor ligands in the treatment of depression
2019/33/B/NZ7/02822
Keywords:
5-HT7 receptor Gs protein beta-arrestin receptor constitutive activity functional selectivity Cdc42 kinase matrix metalloproteinase MMP-9 biased ligands depression memory decline mechanochemistry
Descriptors:
- NZ7_014:
Panel:
NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution :
Uniwersytet Jagielloński, Collegium Medicum
woj. małopolskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 14
Call: OPUS 17 - announced on 2019-03-15
Amount awarded: 2 148 800 PLN
Project start date (Y-m-d): 2020-03-02
Project end date (Y-m-d): 2025-03-01
Project duration:: 60 months (the same as in the proposal)
Project status: Project completed
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (2)
- Sustainable synthesis of a potent and selective 5-HT7 receptor antagonist using a mechanochemical approach.Authors:Vittorio Canale, Valeria Frisi, Xavier Bantreil, Frederic Lamaty, Paweł ZajdelAcademic press:Journal of Organic Chemistry (rok: 2020, tom: 85, strony: 10958–10965), Wydawca: ACSStatus:PublishedDOI:10.1021/acs.joc.0c01044 - link to the publication
- Design, sustainable synthesis and biological evaluation of a novel dual α2A/5-HT7 receptor antagonist with antidepressant-like propertiesAuthors:Vittorio Canale; Magdalena Kotańska; Anna Dziubina; Matylda Stefaniak; Agata Siwek; Gabriela Starowicz; Krzysztof Marciniec; Patryk Kasza; Grzegorz Satała; Beata Duszyńska; Xavier Bantreil; Frederic Lamaty; Marek Bednarski; Jacek Sapa; Paweł ZajdelAcademic press:Molecules (rok: 2021, tom: 26, strony: 3828), Wydawca: MDPIStatus:PublishedDOI:10.3390/molecules26133828 - link to the publication