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DEVELOPMENT OF NEW CLASS PHOTOACTIVATED ANTICANCER-ANTIFUNGAL COMPOUNDS: CONJUGATES OF GOLD NANOPARTICLE-SUPPORTED QUINONE METHIDES-ANTICANCER DRUGS, FOR MULTIMODAL TREATMENT OF URINARY BLADDER TUMORS

2019/33/B/NZ7/01608

Keywords

Descriptors

  • ST4_008: Chemia organiczna
  • NZ1_001: Biologia molekularna
  • NZ7_014: Farmacja, farmakoterapia, farmakologia

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Katolicki Uniwersytet Lubelski Jana Pawła II, Wydział Medyczny

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Oleh M. Demchuk

Number of co-investigators in the project: 10

Call

OPUS 17 – announced on 2019-03-15

Amount awarded
2 546 120 PLN
Project start date
2020-03-25
Project end date
2026-03-24
Project duration
72 months (the same as in the proposal)
Project status
Project completed

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (9)

  1. An Efficient Asymmetric Cross-Coupling Reaction in Aqueous Media Mediated by Chiral Chelating Mono Phosphane Atropisomeric Biaryl Ligand

    Authors:
    Katarzyna Kapłon, Sławomir Frynas, Barbara Mirosław, Janusz Lipkowski, Oleg M. Demchuk
    Academic press:
    Catalysts (year: 2023, volume: 13, pages: 353), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/catal13020353 – link to the publication

  2. A Modular Approach to Atropisomeric Bisphosphines of Diversified Electronic Density on Phosphorus Atoms

    Authors:
    Demchuk, O.M.; Martyna, A.; Kwaśnik, M.; Szwaczko, K.; Strzelecka, D.; Mirosław, B.; Pietrusiewicz, K.M.; Urbanczyk-Lipkowska, Z.
    Academic press:
    Molecules (year: 2022, volume: 27, pages: 5504), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules27175504 – link to the publication

  3. Silver Is Not Equal to Silver: Synthesis and Evaluation of Silver Nanoparticles with Low Biological Activity, and Their Incorporation into C12Alanine-Based Hydrogel

    Authors:
    Konrad Kubiński, Kamila Górka, Monika Janeczko, Aleksandra Martyna, Mateusz Kwaśnik, Maciej Masłyk, Emil Zięba, Joanna Kowalczuk, Piotr Kuśtrowski, Mariusz Borkowski, Anna Boguszewska-Czubara, Agnieszka Klimeczek, Oleg M. Demchuk
    Academic press:
    Molecules (year: 2023, volume: 28, pages: 1194), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules28031194 – link to the publication

  4. Low-Molecular-Weight Organogelators Based on N-dodecanoyl-L-amino Acids—Energy Frameworks and Supramolecular Synthons

    Authors:
    Barbara Miroslaw, Oleg M. Demchuk, Roman Luboradzki, Katarzyna Tyszczuk-Rotko
    Academic press:
    Materials (year: 2023, volume: 16, pages: 702), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ma16020702 – link to the publication

  5. Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

    Authors:
    Michał Janowski, Oleg M. Demchuk, Monika Wujec
    Academic press:
    Molecules (year: 2024, volume: 29, pages: 2855), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules29122855 – link to the publication

  6. A Single Biaryl Monophosphine Ligand Motif—The Multiverse of Coordination Modes

    Authors:
    Miroslaw, B.; Dybala, I.; Jasiński, R.; Demchuk, O.M.
    Academic press:
    Inorganics (year: 2023, volume: 11, pages: 399), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/inorganics11100399 – link to the publication

  7. New supramolecular drug carriers: The study of organogel conjugated gold nanoparticles

    Authors:
    Joanna Kowalczuk, Andrzej Łapiński, Elżbieta Stolarczyk, Oleg M. Demchuk, Konrad Kubiński, Monika Janeczko, Aleksandra Martyna, Maciej Masłyk, Sylwia Turczyniak-Surdacka 4
    Academic press:
    Molecules (year: 2021, volume: 26, pages: 7462), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules26247462 – link to the publication

  8. Experimental and theoretical study of adsorption of synthesized amino acid core derived surfactants at an air/water interface

    Authors:
    M. Borkowski, S. Orvalho, P. Warszyński, Oleg M. Demchuk, E. Jareka, J. Zawala
    Academic press:
    Phys. Chem. Chem. Phys. (year: 2022, volume: 24, pages: 3854), Publisher: RCS
    Status:
    Published
    DOI:
    10.1039/D1CP05322A – link to the publication

  9. Arylcyanomethylenequinone Oximes: An Overview of Synthesis, Chemical Transformations, and Biological Activity

    Authors:
    Kula, K.; Nagatsky, R.; Sadowski, M.; Siumka, Y.; Demchuk, O.M.
    Academic press:
    Molecules (year: 2023, volume: 28, pages: 5229), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules28135229 – link to the publication

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