Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Functional significance of interaction of unconventional myosin VI with the AKAP9-PKA complex: Potential novel regulatory mechanism for muscle contraction and myogenic cell differentiation

2017/27/B/NZ3/01984

Keywords:

skeletal muscle myoblasts myosin VI PKA kinase AKAP9 CREB cAMP phoshorylation

Descriptors:

  • NZ3_1: Cell biology
  • NZ3_2: Cell physiology
  • NZ3_7: Signal transduction

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Biologii Doświadczalnej im. M. Nenckiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Maria Rędowicz 

Number of co-investigators in the project: 8

Call: OPUS 14 - announced on 2017-09-15

Amount awarded: 1 187 200 PLN

Project start date (Y-m-d): 2018-07-31

Project end date (Y-m-d): 2022-07-30

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Stanowisko do badania in vitro skurczu mięśni i pojedynczych włókien mięśniowych (220 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (2)
  1. Mechanisms regulating myoblast fusion: A multilevel interplay.
    Authors:
    Lehka L, Rędowicz MJ.
    Academic press:
    Seminars in Cell and Developmental Biology (rok: 2020, tom: 104, strony: 81-92), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.semcdb.2020.02.004 - link to the publication
  2. Loss of unconventional myosin VI affects cAMP/PKA signaling in hindlimb skeletal muscle in an age-dependent manner.
    Authors:
    Lehka L., Wojton D., Topolewska M., Chumak V., Majewski L., Redowicz MJ.
    Academic press:
    Frontiers in Physiology (rok: 2022, tom: 13, strony: 933963), Wydawca: Frontiers Media S.A.
    Status:
    Published
    DOI:
    10.3389/fphys.2022.933963 - link to the publication
  3. Formation of Aberrant Myotubes by Myoblasts Lack-ing Myosin VI Is Associated with Alterations in the Cytoskeleton Organization, Myoblast Adhesion and Fusion.
    Authors:
    L. Lehka, M. Topolewska, D. Wojton, O. Karatsai, P. Alvarez-Suarez, P. Pomorski, M.J. Rędowicz
    Academic press:
    Cells (rok: 2020, tom: 9(7), strony: 1673), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells9071673 - link to the publication
  4. Plastyczność mięśni szkieletowych: od miogenezy po regenerację
    Authors:
    Wojton D., Redowicz M.J.
    Academic press:
    Kosmos (rok: 2020, tom: 69, strony: 689-702), Wydawca: Polskie Towarzystwo Przyrodników im. Kopernika
    Status:
    Published
    DOI:
    10.36921/kos.2020_2708 - link to the publication
  1. Lack of myosin VI affects morphology and mTOR pathway in murine hindlimb muscles
    Authors:
    D. Wojton, L. Lehka, M.J. Rędowicz
    Conference:
    Virtual European Muscle Conference (rok: 2021, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 20-22 września 2021
    Status:
    Published
    DOI:
    link to the publication
  2. The role of unconventional MVI during myogenic differentiation
    Authors:
    L. Lehka, M. J. Rędowicz.
    Conference:
    Virtual European Muscle Conference (rok: 2021, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 20-22 września 2021
    Status:
    Published
    DOI:
    link to the publication

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