Regulation of carnitine transporters secretory pathway by AKT - a kinase hyperactivated in cancer cells
2018/31/B/NZ3/00669
Keywords
Descriptors
- NZ3_1: Biologia komórki
- NZ3_7: Przekaźnictwo sygnału
- NZ3_2: Fizjologia komórki
Panel
NZ3 – Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology
Host institution
Instytut Biologii Doświadczalnej im. M. Nenckiego PAN
Voivodeship: mazowieckie
Principal investigator (from the host institution)
Number of co-investigators in the project: 3
Call
OPUS 16 – announced on 2018-09-14
- Amount awarded
- 1 275 200 PLN
- Project start date
- 2019-07-01
- Project end date
- 2022-12-31
- Project duration
- 42 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- Aparat do elektroforezy. Cost: 2 468 PLN
- Cieplarka 37oC do hodowli bakteryjnych. Cost: 8 000 PLN
- Inkubator CO2 do hodowli komórkowych typu "Cell Locker" z wnętrzem z miedzi, z filtrami. Cost: 94 000 PLN
Information in the final report
Publication in academic press/journals (4)
-
Trafficking of the cell surface amino acid transporter SLC6A14 upregulated in cancer is controlled by phosphorylation of SEC24C protein by AKT knase
- Authors:
- Kovalchuk V., Nalecz K.A.
- Academic press:
- Cells (year: 2021, volume: 10, pages: 18000), Publisher: MDPI
- Status:
- Published
-
The activity and surface presence of organic cation/carnitine transporter OCTN2 (SLC22A5) in breast cancer cells depends on AKT kinase
- Authors:
- Papierniak-Wyglądała A., Lamch W., Jurewicz E. , Nałęcz K.A.
- Academic press:
- Archives of Biochemistry and Biophysics (year: 2023, volume: 742, pages: 109616), Publisher: Elsevier
- Status:
- Published
-
Amino acid transporter SLCA14 (ATB0,+) – A target in combined anti-cancer therapy
- Authors:
- Nałęcz K.A.
- Academic press:
- Front. Cell Dev. Biol. (year: 2020, volume: 8, pages: 46035), Publisher: Frontiers
- Status:
- Published
- DOI:
- 10.3389/fcell.2020.594464. – link to the publication
-
SLC22A5 (OCTN2) Carnitine Transporter - Indispensable for Cell metabolism, a Jekyll and Hyde of Human Cancer
- Authors:
- Juraszek B.,, Nałęcz K.A.
- Academic press:
- Molecules (year: 2020, volume: 25, pages: 14), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/molecules25010014 – link to the publication