Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Evaluation of endoplasmic reticulum stress control by endogenous lipids in the context of its anticancer therapeutic potential

2019/33/B/NZ5/03034

Keywords:

ER stress PERK kinase unfolded protein response lipids

Descriptors:

  • NZ1_001:
  • NZ5_003:
  • NZ3_007:

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Dariusz Maciej Pytel 

Number of co-investigators in the project: 3

Call: OPUS 17 - announced on 2019-03-15

Amount awarded: 1 540 000 PLN

Project start date (Y-m-d): 2020-05-04

Project end date (Y-m-d): 2025-05-03

Project duration:: 60 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  1. The Structure, Activation and Signaling of IRE1 and Its Role in Determining Cell Fate
    Authors:
    Natalia Siwecka, Wioletta Rozpedek-Kaminska, Adam Wawrzynkiewicz, Dariusz Pytel, J. Alan Diehl, Ireneusz Majsterek
    Academic press:
    Biomedicines (rok: 2021, tom: 9, 156, strony: 45686), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biomedicines9020156 - link to the publication
  2. Carbon monoxide activates PERK-regulated autophagy to induce immunometabolic reprogramming and boost anti-tumor T cell function
    Authors:
    Paramita Chakraborty, Rasesh Y. Parikh, Seungho Choi, Danh Tran, Monika Gooz, Zachariah T. Hedley, Do-Sung Kim, Dariusz Pytel, Inhong Kang, Satish N. Nadig, Gyda C. Beeson, Lauren Ball, Meenal Mehrotra, Hongjun Wang, Stefano Berto, Viswanathan Palanisamy, Hong Li , Shilpak Chatterjee , Paulo C. Rodriguez, Eduardo N. Maldonado, J. Alan Diehl, Vamsi K. Gangaraju, Shikhar Mehrotra
    Academic press:
    Cancer Research (rok: 2022, tom: 82(10):1969-1990, strony: 15342), Wydawca: AACR Journals
    Status:
    Published
    DOI:
    10.1158/0008-5472.CAN-21-3155 - link to the publication
  3. The Structure, Activation and Signaling of IRE1 and Its Role in Determining Cell Fate
    Authors:
    Natalia Siwecka, Wioletta Rozpedek-Kaminska, Adam Wawrzynkiewicz, Dariusz Pytel, J. Alan Diehl, Ireneusz Majsterek
    Academic press:
    Biomedicines (rok: 2021, tom: 9, 156, strony: 45686), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biomedicines9020156 - link to the publication
  4. Carbon monoxide activates PERK-regulated autophagy to induce immunometabolic reprogramming and boost anti-tumor T cell function
    Authors:
    Paramita Chakraborty, Rasesh Y. Parikh, Seungho Choi, Danh Tran, Monika Gooz, Zachariah T. Hedley, Do-Sung Kim, Dariusz Pytel, Inhong Kang, Satish N. Nadig, Gyda C. Beeson, Lauren Ball, Meenal Mehrotra, Hongjun Wang, Stefano Berto, Viswanathan Palanisamy, Hong Li , Shilpak Chatterjee , Paulo C. Rodriguez, Eduardo N. Maldonado, J. Alan Diehl, Vamsi K. Gangaraju, Shikhar Mehrotra
    Status:
    Accepted for publication

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