Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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The role of diacylglycerol kinase epsilon, an enzyme of the phosphatidylinositol cycle, in the regulation of LPS-induced pro-inflammatory signaling of macrophages

2018/29/B/NZ3/00407

Keywords:

LPS diacylglicerol kinase palmitoylation phosphatidylinositols TLR4 pro-inflammatory response cellular membranes

Descriptors:

  • NZ3_1:
  • NZ3_7:

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Katarzyna Kwiatkowska 

Number of co-investigators in the project: 5

Call: OPUS 15 - announced on 2018-03-15

Amount awarded: 1 480 000 PLN

Project start date (Y-m-d): 2019-01-21

Project end date (Y-m-d): 2023-01-20

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (6)
  1. Diacylglycerol kinase-ε is S-palmitoylated on cysteine in the cytoplasmic end of its N-terminal transmembrane fragment
    Authors:
    Gabriela Traczyk, Aneta Hromada-Judycka, Anna Świątkowska, Julia Wiśniewska, Anna Ciesielska, Katarzyna Kwiatkowska
    Academic press:
    Journal of Lipid Reserach (rok: 2024, tom: 65(1) 100480, strony: 45677), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jlr.2023.100480 - link to the publication
  2. Flotillins: At the Intersection of Protein S-Palmitoylation and Lipid-Mediated Signaling
    Authors:
    Katarzyna Kwiatkowska, Orest V. Matveichuk, Jan Fronk, Anna Ciesielska
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 45683), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21072283 - link to the publication
  3. An intact zinc finger motif of the C1B domain is critical for stability and activity of diacylglycerol kinase-ε
    Authors:
    Gabriela Traczyk, Anna Swiątkowska, Aneta Hromada-Judycka, Justyna Janikiewicz, Katarzyna Kwiatkowska
    Academic press:
    International Journal of Biochemistry and Cell Biology (rok: 2022, tom: 152; 106295, strony: 45670), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biocel.2022.106295 - link to the publication
  4. Flotillins affect LPS-induced TLR4 signaling by modulating the trafficking and abundance of CD14
    Authors:
    Orest V. Matveichuk, Anna Ciesielska, Aneta Hromada-Judycka, Natalia Nowak, Ichrak Ben Amore, Gabriela Traczyk, Katarzyna Kwiatkowska
    Academic press:
    Cellular and Molecular Life Sciences (rok: 2024, tom: 81:191, strony: 45682), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00018-024-05221-3 - link to the publication
  5. Diacylglycerol kinase-ε is S-palmitoylated on cysteine in the cytoplasmic end of its N-terminal transmembrane fragment
    Authors:
    Gabriela Traczyk, Aneta Hromada-Judycka, Anna Świątkowska, Julia Wiśniewska, Anna Ciesielska, Katarzyna Kwiatkowska
    Academic press:
    Journal of Lipid Reserach (rok: 2024, tom: 65(1) 100480, strony: 45677), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jlr.2023.100480 - link to the publication
  6. An intact zinc finger motif of the C1B domain is critical for stability and activity of diacylglycerol kinase-ε
    Authors:
    Gabriela Traczyk, Anna Swiątkowska, Aneta Hromada-Judycka, Justyna Janikiewicz, Katarzyna Kwiatkowska
    Academic press:
    International Journal of Biochemistry and Cell Biology (rok: 2022, tom: 152; 106295, strony: 45670), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biocel.2022.106295 - link to the publication

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