Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

The influence of impairment of extracellular nucleoside and nucleotide signaling on synaptic structure and function in autism

2017/25/B/NZ4/01969

Keywords:

autism purinergic receptors adenosine receptors AMPK kinase mTOR autophagy translation synapse

Descriptors:

  • NZ4_9: Systems neurobiology
  • NZ3_7: Signal transduction
  • NZ3_5: Molecular neurobiology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Agata Adamczyk 

Number of co-investigators in the project: 7

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 998 390 PLN

Project start date (Y-m-d): 2018-01-25

Project end date (Y-m-d): 2022-01-24

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. oprogramowanie biurowe i naukowe (5 000 PLN)
  2. system do znakowania zwierząt laboratoryjnych (5 000 PLN)
  3. termocykler (45 000 PLN)
  4. Wyposażenie do elektroforezy i transferu białek (20 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (6)
  1. Prenatal Exposure to Valproic Acid Affects Microglia and Synaptic Ultrastructure in a Brain-Region-Specific Manner in Young-Adult Male Rats: Relevance to Autism Spectrum Disorders.
    Authors:
    Gąssowska-Dobrowolska M, Cieślik M, Czapski GA, Jęśko H, Frontczak-Baniewicz M, Gewartowska M, Dominiak A, Polowy R, Filipkowski RK, Babiec L, Adamczyk A.
    Academic press:
    Int. J. Mol. Sci. (rok: 2020, tom: 21(10), strony: 3576), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21103576 - link to the publication
  2. Alterations in Tau protein level and phosphorylation state in the brain of the autistic-like rats induced by prenatal exposure to valproic acid.
    Authors:
    Gąssowska-Dobrowolska M, Kolasa-Wołosiuk A, Cieślik M, Dominiak A, Friedland K, Adamczyk A
    Academic press:
    IJMS (rok: 2021, tom: 22,6, strony: 3209), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22063209. - link to the publication
  3. Dysfunctional proteins in neuropsychiatric disorders: From neurodegeneration to autism spectrum disorders.
    Authors:
    Jęśko H, Cieślik M, Gromadzka G, Adamczyk A
    Academic press:
    Neurochem Int. (rok: 2020, tom: 141, strony: 104853), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuint.2020.104853 - link to the publication
  4. Synaptic alterations in a transgenic model of tuberous sclerosis complex: relevance to autism spectrum disorders
    Authors:
    Czapski GA, Babiec L, Jęśko H, Gąssowska-Dobrowolska M, Cieślik M, Matuszewska M, Frontczak-Baniewicz M, Zajdel K, Adamczyk A.
    Academic press:
    IJMS (rok: 2021, tom: 22,18, strony: 10058), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms221810058 - link to the publication
  1. Prenatal exposure to valproic acid induces changes in the expression of purinergic receptors during rat brain development
    Authors:
    Babiec L, Wilkaniec A, Matuszewska M, Adamczyk A
    Conference:
    the 16th Biennial Meeting of the Asian-Pacific Society for Neurochemistry (APSN) Singapour (rok: 2021, ), Wydawca: APSN
    Data:
    konferencja December 13-14
    Status:
    Published
  2. Alterations in synaptic ultrastructure in mouse models of tuberous sclerosis complex; relevance to autism spectrum disorders.
    Authors:
    Babiec L, Czapski GA, Gąssowska-Dobrowolska M, Frontczak-Baniewicz M, Zajdel K, Adamczyk A
    Conference:
    the 16th Biennial Meeting of the Asian-Pacific Society for Neurochemistry (APSN) Singapour (rok: 2021, ), Wydawca: APSN
    Data:
    konferencja December 13-14
    Status:
    Published
  3. Alterations in the expression of purinergic receptors in adolescent rats following embryological exposure to valproic acid.
    Authors:
    1.Wilkaniec A., Cieslik M., Czapski G.A., Filipkowski R.K., Boguszewski P.M., Matuszewska M., Adamczyk A
    Conference:
    the 14th International Symposium Molecular Basis Of Pathology And Therapy In Neurological Disorders (rok: 2018, ), Wydawca: Termedia
    Data:
    konferencja 25-26.10.2018
    Status:
    Published
  4. Prenatal exposure to valproic acid leads to deregulation of purinergic signaling in the brain of adolescent rats.
    Authors:
    Babiec L, Wilkaniec A, Matuszewska M, Hilgier W, Adamczyk A.
    Conference:
    XIV Międzynarodowy Kongres Polskiego Towarzystwa Badań Układu Nerwowego/XXIV International Congress of the Polish Neuroscience Society (rok: 2019, ), Wydawca: Acta Neurobiol Exp
    Data:
    konferencja 2019-08-28-30
    Status:
    Published
  5. Mitochondrial dysfunction and purinergic signalling alterations in the prenatal valproic acid rodent model of autism spectrum disorder.
    Authors:
    Babiec L, Wilkaniec A, Adamczyk A.
    Conference:
    8th MITOCHONDRION: in memory of Prof. L. Wojtczak, Warszawa 5.02.2020 (rok: 2020, ), Wydawca: Inst. Biol. Dośw.im. M. Nenckiego
    Data:
    konferencja 43866
    Status:
    Published
  6. Prenatal exposure to valproic acid leads to behavioral alterations and defects of synaptic proteins in the hippocamus of adolescent rats.
    Authors:
    Adamczyk A, Gąssowska-Dobrowolska M, Cieślik M, Czapski GA, Jęśko H, Gewartowska M, Frontczak-Baniewicz M
    Conference:
    XIV Międzynarodowy Kongres Polskiego Towarzystwa Badań Układu Nerwowego/XXIV International Congress of the Polish Neuroscience Society (rok: 2019, ), Wydawca: Acta Neurobiol Exp
    Data:
    konferencja 2019-08-28-30
    Status:
    Published

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy