Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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The influence of impairment of extracellular nucleoside and nucleotide signaling on synaptic structure and function in autism

2017/25/B/NZ4/01969

Keywords:

autism purinergic receptors adenosine receptors AMPK kinase mTOR autophagy translation synapse

Descriptors:

  • NZ4_9: Systems neurobiology
  • NZ3_7: Signal transduction
  • NZ3_5: Molecular neurobiology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Agata Adamczyk 

Number of co-investigators in the project: 7

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 998 390 PLN

Project start date (Y-m-d): 2018-01-25

Project end date (Y-m-d): 2022-01-24

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. system do znakowania zwierząt laboratoryjnych (5 000 PLN)
  2. Wyposażenie do elektroforezy i transferu białek (20 000 PLN)
  3. oprogramowanie biurowe i naukowe (5 000 PLN)
  4. termocykler (45 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (6)
  1. Alterations in Tau protein level and phosphorylation state in the brain of the autistic-like rats induced by prenatal exposure to valproic acid.
    Authors:
    Gąssowska-Dobrowolska M, Kolasa-Wołosiuk A, Cieślik M, Dominiak A, Friedland K, Adamczyk A
    Academic press:
    IJMS (rok: 2021, tom: 22,6, strony: 3209), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22063209. - link to the publication
  2. Synaptic alterations in a transgenic model of tuberous sclerosis complex: relevance to autism spectrum disorders
    Authors:
    Czapski GA, Babiec L, Jęśko H, Gąssowska-Dobrowolska M, Cieślik M, Matuszewska M, Frontczak-Baniewicz M, Zajdel K, Adamczyk A.
    Academic press:
    IJMS (rok: 2021, tom: 22,18, strony: 10058), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms221810058 - link to the publication
  3. Dysfunctional proteins in neuropsychiatric disorders: From neurodegeneration to autism spectrum disorders.
    Authors:
    Jęśko H, Cieślik M, Gromadzka G, Adamczyk A
    Academic press:
    Neurochem Int. (rok: 2020, tom: 141, strony: 104853), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuint.2020.104853 - link to the publication
  4. Prenatal Exposure to Valproic Acid Affects Microglia and Synaptic Ultrastructure in a Brain-Region-Specific Manner in Young-Adult Male Rats: Relevance to Autism Spectrum Disorders.
    Authors:
    Gąssowska-Dobrowolska M, Cieślik M, Czapski GA, Jęśko H, Frontczak-Baniewicz M, Gewartowska M, Dominiak A, Polowy R, Filipkowski RK, Babiec L, Adamczyk A.
    Academic press:
    Int. J. Mol. Sci. (rok: 2020, tom: 21(10), strony: 3576), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21103576 - link to the publication
  1. Prenatal exposure to valproic acid leads to deregulation of purinergic signaling in the brain of adolescent rats.
    Authors:
    Babiec L, Wilkaniec A, Matuszewska M, Hilgier W, Adamczyk A.
    Conference:
    XIV Międzynarodowy Kongres Polskiego Towarzystwa Badań Układu Nerwowego/XXIV International Congress of the Polish Neuroscience Society (rok: 2019, ), Wydawca: Acta Neurobiol Exp
    Data:
    konferencja 2019-08-28-30
    Status:
    Published
  2. Alterations in synaptic ultrastructure in mouse models of tuberous sclerosis complex; relevance to autism spectrum disorders.
    Authors:
    Babiec L, Czapski GA, Gąssowska-Dobrowolska M, Frontczak-Baniewicz M, Zajdel K, Adamczyk A
    Conference:
    the 16th Biennial Meeting of the Asian-Pacific Society for Neurochemistry (APSN) Singapour (rok: 2021, ), Wydawca: APSN
    Data:
    konferencja December 13-14
    Status:
    Published
  3. Prenatal exposure to valproic acid induces changes in the expression of purinergic receptors during rat brain development
    Authors:
    Babiec L, Wilkaniec A, Matuszewska M, Adamczyk A
    Conference:
    the 16th Biennial Meeting of the Asian-Pacific Society for Neurochemistry (APSN) Singapour (rok: 2021, ), Wydawca: APSN
    Data:
    konferencja December 13-14
    Status:
    Published
  4. Prenatal exposure to valproic acid leads to behavioral alterations and defects of synaptic proteins in the hippocamus of adolescent rats.
    Authors:
    Adamczyk A, Gąssowska-Dobrowolska M, Cieślik M, Czapski GA, Jęśko H, Gewartowska M, Frontczak-Baniewicz M
    Conference:
    XIV Międzynarodowy Kongres Polskiego Towarzystwa Badań Układu Nerwowego/XXIV International Congress of the Polish Neuroscience Society (rok: 2019, ), Wydawca: Acta Neurobiol Exp
    Data:
    konferencja 2019-08-28-30
    Status:
    Published
  5. Alterations in the expression of purinergic receptors in adolescent rats following embryological exposure to valproic acid.
    Authors:
    1.Wilkaniec A., Cieslik M., Czapski G.A., Filipkowski R.K., Boguszewski P.M., Matuszewska M., Adamczyk A
    Conference:
    the 14th International Symposium Molecular Basis Of Pathology And Therapy In Neurological Disorders (rok: 2018, ), Wydawca: Termedia
    Data:
    konferencja 25-26.10.2018
    Status:
    Published
  6. Mitochondrial dysfunction and purinergic signalling alterations in the prenatal valproic acid rodent model of autism spectrum disorder.
    Authors:
    Babiec L, Wilkaniec A, Adamczyk A.
    Conference:
    8th MITOCHONDRION: in memory of Prof. L. Wojtczak, Warszawa 5.02.2020 (rok: 2020, ), Wydawca: Inst. Biol. Dośw.im. M. Nenckiego
    Data:
    konferencja 43866
    Status:
    Published

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