Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Role of PIM kinases in the biology of classical Hodgkin lymphoma tumor-associated macrophages

2017/26/D/NZ5/00561

Keywords:

classical Hodgkin lymphoma PIM kinases tumor-associated macrophages

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ5_7: Human disease treatment

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Hematologii i Transfuzjologii

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Maciej Szydłowski 

Number of co-investigators in the project: 2

Call: SONATA 13 - announced on 2017-06-14

Amount awarded: 892 450 PLN

Project start date (Y-m-d): 2018-04-27

Project end date (Y-m-d): 2023-04-26

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. HUB USB TP-LINK UH700.
  2. Kabel Unitek HDMI (Y-C138).
  3. Komputer przenośny wraz z oprogramowaniem do analizy danych (6 000 PLN)
  4. Monitor iiyama XUB2395WSU-B1.
  5. Dysk zewnętrzny przenośny SanDisc 500 GB.

Information in the final report

  • Publication in academic press/journals (1)
  • Articles in post-conference publications (4)
  1. Inhibition of PIM Kinases in DLBCL Targets MYC Transcriptional Program and Augments the Efficacy of Anti-CD20 Antibodies
    Authors:
    Maciej Szydłowski, Filip Garbicz, Ewa Jabłońska, Patryk Górniak, Dorota Komar, Beata Pyrzyńska, Kamil Bojarczuk, Monika Prochorec-Sobieszek, Anna Szumera-Ciećkiewicz, Grzegorz Rymkiewicz, Magdalena Cybulska, Małgorzata Statkiewicz, Marta Gajewska, Michał Mikula, Aniela Gołas, Joanna Domagała, Magdalena Winiarska, Agnieszka Graczyk-Jarzynka, Emilia Białopiotrowicz, Anna Polak, Joanna Barankiewicz, Bartosz Puła, Michał Pawlak, Dominika Nowis, Jakub Golab, Andrea M Tomirotti, Krzysztof Brzózka, Mariana Pacheco-Blanco, Kristyna Kupcova, Michael R Green, Ondrej Havranek, Bjoern Chapuy, Przemysław Juszczyński
    Academic press:
    Cancer Research (rok: 2021, tom: 81 (23), strony: 6029–6043), Wydawca: American Association for Cancer Research
    Status:
    Published
    DOI:
    10.1158/0008-5472.CAN-21-1023 - link to the publication
  1. Hodgkin Lymphoma Reed-Sternberg Cells Induce Immunosuppressive and Pro-Angiogenic Phenotype of Tumor-Associated Macrophages in a Paracrine Manner
    Authors:
    Maciej Szydlowski, Michał Pawlak, Filip Garbicz, Patryk Górniak, Justyna Żurańska, Magdalena Król, Bartłomiej Taciak , Maciej Białasek , Anna Szumera-Ciećkiewicz, Kamil Sokół , Monika Stańczak, Daria Owczarek , Monika Prochorec-Sobieszek, Anna Polak, Emilia Bialopiotrowicz, Michał Kurlapski , Jan Zaucha, Paweł Wołkow, Przemyslaw Juszczynski
    Conference:
    Virtual 62nd ASH Annual Meeting & Exposition (rok: 2020, ), Wydawca: Blood, American Society of Hematology
    Data:
    konferencja 11-14.12.2020
    Status:
    Published
  2. Inhibition of PIM Kinases in Diffuse Large B-Cell Lymphoma Cells Targets MYC-Dependent Transcriptional Program, Increases CD20 Expression and Augments the Efficacy of Anti-CD20 Antibodies
    Authors:
    Maciej Szydłowski, Filip Garbicz, Ewa Jabłońska, Patryk Górniak, Beata Pyrzyńska, Kamil Bojarczuk, Dorota Komar, Monika Prochorec-Sobieszek, Anna Szumera-Ciećkiewicz, Grzegorz Rymkiewicz, Magdalena Cybulska, Małgorzata Statkiewicz, Marta Gajewska, Michał Mikula, Aniela Gołas, Joanna Domagała, Magdalena Winiarska, Agnieszka Graczyk-Jarzynka, Emilia Białopiotrowicz, Anna Polak, Joanna Barankiewicz, Bartosz Puła, Michael R. Green, Dominika Nowis, Jakub Gołąb, Andrea M. Tomirotti, Krzysztof Brzózka, Marian Pacheco-Blanco, Kristyna Kupcova, Ondrej Havranek, Bjoern Chapuy, Przemysław Juszczyński
    Conference:
    Virtual 62nd ASH Annual Meeting & Exposition (rok: 2020, ), Wydawca: Blood, American Society of Hematology
    Data:
    konferencja 11-14.12.2020
    Status:
    Published
  3. PIM kinases support protumoral and immunosuppressive phenotype and functions of macrophages in classical Hodgkin Lymphoma
    Authors:
    Maciej Szydłowski; Filip Garbicz; Ewa Kurtz; Michał Pawlak; Patryk Górniak; Anna Szumera-Ciećkiewicz; Kamil Sokół.; Monika Kawecka; Daria Owczarek; Beata Puton et al.
    Conference:
    12th INTERNATIONAL SYMPOSIUM ON HODGKIN LYMPHOMA (rok: 2022, ), Wydawca: Hemasphere
    Data:
    konferencja 3,1
    Status:
    Published
    DOI:
    link to the publication
  4. MEN1703-Mediated PIM Kinases Inhibition Impairs Protumoral and Immunosuppressive Phenotype and Functions of Macrophages in Classical Hodgkin Lymphoma
    Authors:
    Maciej Szydlowski; Filip Garbicz; Ewa Kurtz; Justyna Żurańska; Michał Seweryn; Michał Pawlak; Patryk Górniak; Kamil Sokół; Anna Szumera-Ciećkiewicz; Monika Kawecka et al.
    Conference:
    64th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH) (rok: 2022, ), Wydawca: ASH
    Data:
    konferencja 10-13.12
    Status:
    Published
    DOI:
    link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy