Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Role of PIM kinases in the biology of classical Hodgkin lymphoma tumor-associated macrophages

2017/26/D/NZ5/00561

Keywords:

classical Hodgkin lymphoma PIM kinases tumor-associated macrophages

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ5_7: Human disease treatment

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Hematologii i Transfuzjologii

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Maciej Szydłowski 

Number of co-investigators in the project: 2

Call: SONATA 13 - announced on 2017-06-14

Amount awarded: 892 450 PLN

Project start date (Y-m-d): 2018-04-27

Project end date (Y-m-d): 2023-04-26

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. HUB USB TP-LINK UH700.
  2. Dysk zewnętrzny przenośny SanDisc 500 GB.
  3. Komputer przenośny wraz z oprogramowaniem do analizy danych (6 000 PLN)
  4. Kabel Unitek HDMI (Y-C138).
  5. Monitor iiyama XUB2395WSU-B1.

Information in the final report

  • Publication in academic press/journals (1)
  • Articles in post-conference publications (4)
  1. Inhibition of PIM Kinases in DLBCL Targets MYC Transcriptional Program and Augments the Efficacy of Anti-CD20 Antibodies
    Authors:
    Maciej Szydłowski, Filip Garbicz, Ewa Jabłońska, Patryk Górniak, Dorota Komar, Beata Pyrzyńska, Kamil Bojarczuk, Monika Prochorec-Sobieszek, Anna Szumera-Ciećkiewicz, Grzegorz Rymkiewicz, Magdalena Cybulska, Małgorzata Statkiewicz, Marta Gajewska, Michał Mikula, Aniela Gołas, Joanna Domagała, Magdalena Winiarska, Agnieszka Graczyk-Jarzynka, Emilia Białopiotrowicz, Anna Polak, Joanna Barankiewicz, Bartosz Puła, Michał Pawlak, Dominika Nowis, Jakub Golab, Andrea M Tomirotti, Krzysztof Brzózka, Mariana Pacheco-Blanco, Kristyna Kupcova, Michael R Green, Ondrej Havranek, Bjoern Chapuy, Przemysław Juszczyński
    Academic press:
    Cancer Research (rok: 2021, tom: 81 (23), strony: 6029–6043), Wydawca: American Association for Cancer Research
    Status:
    Published
    DOI:
    10.1158/0008-5472.CAN-21-1023 - link to the publication
  1. MEN1703-Mediated PIM Kinases Inhibition Impairs Protumoral and Immunosuppressive Phenotype and Functions of Macrophages in Classical Hodgkin Lymphoma
    Authors:
    Maciej Szydlowski; Filip Garbicz; Ewa Kurtz; Justyna Żurańska; Michał Seweryn; Michał Pawlak; Patryk Górniak; Kamil Sokół; Anna Szumera-Ciećkiewicz; Monika Kawecka et al.
    Conference:
    64th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH) (rok: 2022, ), Wydawca: ASH
    Data:
    konferencja 10-13.12
    Status:
    Published
    DOI:
    link to the publication
  2. Hodgkin Lymphoma Reed-Sternberg Cells Induce Immunosuppressive and Pro-Angiogenic Phenotype of Tumor-Associated Macrophages in a Paracrine Manner
    Authors:
    Maciej Szydlowski, Michał Pawlak, Filip Garbicz, Patryk Górniak, Justyna Żurańska, Magdalena Król, Bartłomiej Taciak , Maciej Białasek , Anna Szumera-Ciećkiewicz, Kamil Sokół , Monika Stańczak, Daria Owczarek , Monika Prochorec-Sobieszek, Anna Polak, Emilia Bialopiotrowicz, Michał Kurlapski , Jan Zaucha, Paweł Wołkow, Przemyslaw Juszczynski
    Conference:
    Virtual 62nd ASH Annual Meeting & Exposition (rok: 2020, ), Wydawca: Blood, American Society of Hematology
    Data:
    konferencja 11-14.12.2020
    Status:
    Published
  3. Inhibition of PIM Kinases in Diffuse Large B-Cell Lymphoma Cells Targets MYC-Dependent Transcriptional Program, Increases CD20 Expression and Augments the Efficacy of Anti-CD20 Antibodies
    Authors:
    Maciej Szydłowski, Filip Garbicz, Ewa Jabłońska, Patryk Górniak, Beata Pyrzyńska, Kamil Bojarczuk, Dorota Komar, Monika Prochorec-Sobieszek, Anna Szumera-Ciećkiewicz, Grzegorz Rymkiewicz, Magdalena Cybulska, Małgorzata Statkiewicz, Marta Gajewska, Michał Mikula, Aniela Gołas, Joanna Domagała, Magdalena Winiarska, Agnieszka Graczyk-Jarzynka, Emilia Białopiotrowicz, Anna Polak, Joanna Barankiewicz, Bartosz Puła, Michael R. Green, Dominika Nowis, Jakub Gołąb, Andrea M. Tomirotti, Krzysztof Brzózka, Marian Pacheco-Blanco, Kristyna Kupcova, Ondrej Havranek, Bjoern Chapuy, Przemysław Juszczyński
    Conference:
    Virtual 62nd ASH Annual Meeting & Exposition (rok: 2020, ), Wydawca: Blood, American Society of Hematology
    Data:
    konferencja 11-14.12.2020
    Status:
    Published
  4. PIM kinases support protumoral and immunosuppressive phenotype and functions of macrophages in classical Hodgkin Lymphoma
    Authors:
    Maciej Szydłowski; Filip Garbicz; Ewa Kurtz; Michał Pawlak; Patryk Górniak; Anna Szumera-Ciećkiewicz; Kamil Sokół.; Monika Kawecka; Daria Owczarek; Beata Puton et al.
    Conference:
    12th INTERNATIONAL SYMPOSIUM ON HODGKIN LYMPHOMA (rok: 2022, ), Wydawca: Hemasphere
    Data:
    konferencja 3,1
    Status:
    Published
    DOI:
    link to the publication

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