Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Structure and function of a unique two-component system of periodontopathogenic bacteria Porphyromonas gingivalis

2018/31/B/NZ1/03968

Keywords:

periodontitis Porphyromonas gingivalis protein secretion T9SS signal transduction pathogenesis virulence factor protein phosphorylation kinase phosphatase

Descriptors:

  • NZ1_2: Biochemistry
  • NZ1_4: Structural biology
  • NZ1_10: Microbiology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Jan Potempa 

Number of co-investigators in the project: 5

Call: OPUS 16 - announced on 2018-09-14

Amount awarded: 2 230 400 PLN

Project start date (Y-m-d): 2019-07-26

Project end date (Y-m-d): 2023-06-25

Project duration:: 47 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Cytometr przepływowy dwukanałowy umożliwiający ilościowy pomiar składu zewnątrzkomórkowego bakterii, wyposażony w odpowiedni komputer i oprogramowanie do analizy danych (500 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. Response regulator PorX coordinates oligonucleotide signalling and gene expression to control the secretion of virulence factors.
    Authors:
    Schmitz C, Madej M, Nowakowska Z, Cuppari A, Jacula A, Ksiazek M, Mikruta K, Wisniewski J, Pudelko-Malik N, Saran A, Zeytuni N, Mlynarz P, Lamont RJ, Usón I, Siksnys V, Potempa J, Solà M.
    Academic press:
    Nucleic Acids Research (rok: 2022, tom: 50, strony: 12558-12557), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gkac1103 - link to the publication
  2. Structural and functional insights into oligopeptide acquisition by the RagAB transporter from Porphyromonas gingivalis.
    Authors:
    Madej M, White JBR, Nowakowska Z, Rawson S, Scavenius C, Enghild JJ, Bereta GP, Pothula K, Kleinekathoefer U, Baslé A, Ranson NA, Potempa J, van den Berg B.
    Academic press:
    Nature Microbiology (rok: 2020, tom: 5, strony: 1016-10215), Wydawca: NATURE PUBLISHING GROUP
    Status:
    Published
    DOI:
    10.1038/s41564-020-0716-y - link to the publication
  3. Unveiling the Molecular Mechanisms of the Type-IX Secretion System's Response Regulator: Structural and Functional Insights
    Authors:
    Anshu Saran, Hey-Min Kim, Ireland Manning, Mark A. Hancock, Claus Schmitz, Mariusz Madej, Jan Potempa, Maria Sola, Jean-François Trempe, Yongtao Zhu, Mary Ellen Davey, Natalie Zeytuni
    Academic press:
    PNAS Nexus , Wydawca: National Academy of Sciences
    Status:
    Submitted
    DOI:
    brak - link to the publication
  4. Phosphorylation of major Porphyromonas gingivalis virulence factors is crucial for their processing and secretion
    Authors:
    Nowakowska Z, Madej M, Grad S, Wang T, Hackett M, Miller DP, Lamont RJ, Potempa J.
    Academic press:
    Molecular Oral Microbiology (rok: 2021, tom: 36, strony: 316-326), Wydawca: Hohn Willey & Sons
    Status:
    Published
    DOI:
    10.1111/omi.12354 - link to the publication
  5. TLR2 Activation by Porphyromonas gingivalis Requires Both PPAD Activity and Fimbriae
    Authors:
    Aleksandra Wielento, Grzegorz P Bereta 1, Katarzyna B Łagosz-Ćwik, Sigrun Eick, Richard J Lamont, Aleksander M Grabiec, Jan Potempa
    Academic press:
    Frontiers in Immunology (rok: 2022, tom: 13, strony: 823685), Wydawca: www.frontiers.com
    Status:
    Published
    DOI:
    10.3389/fimmu.2022.823685 - link to the publication

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