Projects funded by the NCN

Development of novel screening method for identifying xanthine oxidase inhibitors – towards new drug candidates for gout...

Call: PRELUDIUM 23 , Panel: ST4

Principal investigator: Monika Katarzyna Rola

Politechnika Łódzka

Innovative Small Molecule Inhibitors Targeting LAG-3 and MHCII Complex for Tumour Immunotherapy

Call: OPUS 27 , Panel: NZ7

Principal investigator: dr Jacek Plewka

Uniwersytet Jagielloński

Behavioral timescale plasticity in inhibitory synapses: mechanisms and implications

Call: OPUS 27 , Panel: NZ4

Principal investigator: dr Grzegorz Tadeusz Wiera

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu

Controlling the covalent activity of a PD-L1 inhibitors with light

Call: PRELUDIUM 23 , Panel: NZ7

Principal investigator: Wiktor Jan Uzar

Uniwersytet Jagielloński

Development and characterization of novel multitargeted organometallic tubulin polymerization inhibitors for enhancing t...

Call: OPUS 27 , Panel: NZ7

Principal investigator: dr hab. Damian Nestor Plażuk

Uniwersytet Łódzki

Early Intervention with mTOR Inhibitors for Neuropsychiatric Symptoms in Tuberous Sclerosis Complex: Unveiling Developme...

Call: DAINA 3 , Panel: NZ4

Principal investigator: prof. Ewelina Anna Knapska

Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

Selective inhibition of Janus kinases for the treatment of autoimmune hepatitis: Translational PK/PD modelling from mole...

Call: SONATA 19 , Panel: NZ7

Principal investigator: dr Artur Świerczek

Uniwersytet Jagielloński, Collegium Medicum

Inhibitory Functional Networks in Addiction Development within Social Context - a Missing Piece of Puzzle

Call: OPUS 26 , Panel: NZ4

Principal investigator: dr Marzena Stefaniuk

Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

Design, synthesis and biological evaluation of Steroid Sulfatase Inhibitors based on organophosphorus compounds.

Call: SONATA 2 , Panel: NZ7

Principal investigator: dr Sebastian Demkowicz

Politechnika Gdańska

Flozins as potential inhibitors of aortic stenosis progression in patients with concomitant type 2 diabetes: impact on v...

Call: OPUS 26 , Panel: NZ5

Principal investigator: dr hab. Joanna Natorska

Uniwersytet Jagielloński

Modulation of the N-glycosylation as a tool to improve the CAR-T immunotherapy efficacy

Call: OPUS 26 , Panel: NZ7

Principal investigator: dr Agnieszka Graczyk-Jarzynka

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

Targeting adenylate kinase 4 (AK4) as a new paradigm in the treatment of non-small cell lung cancer: discovery and evalu...

Call: OPUS 26 , Panel: NZ7

Principal investigator: dr Magdalena Wujak

Uniwersytet Mikołaja Kopernika w Toruniu, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy

Novel aspects of the mechanisms of vascular toxicity of tyrosine kinase inhibitors: studies on their proinflammatory act...

Call: OPUS 26 , Panel: NZ5

Principal investigator: dr Tomasz Krzysztof Prajsnar

Uniwersytet Jagielloński, Wydział Biologii

Can extracts from Epilobium sp. inhibit proliferation of prostate cell LNCaP by influencing the activity of histone acet...

Call: SONATA 1 , Panel: NZ4

Principal investigator: dr hab. Anna Karolina Kiss

Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny

Functional and structural analysis of anticancer drugs as protein biosynthesis inhibitors

Call: OPUS 26 , Panel: NZ7

Principal investigator: dr hab. Witold Szaflarski

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Medyczny

Design and synthesis of new rifampicin analogs as a source of effective bacterial RNA polymerase inhibitors

Call: OPUS 2 , Panel: ST5

Principal investigator: dr hab. Piotr Przybylski

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

Design and Development of Serine Hydroxymethyltransferase-2 (SHMT2) Inhibitors Blocking Tumor Growth

Call: SONATA BIS 13 , Panel: NZ7

Principal investigator: dr hab. Miłosz Ruszkowski

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Theoretical prediction, chemical synthesis and biological analysis of a novel class of HSPA5 inhibitors

Call: OPUS 25 , Panel: ST4

Principal investigator: prof. Arkadiusz Chworoś

Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

Compounds modulating function of telomeric proteins TRF1 and TRF2

Call: OPUS 25 , Panel: NZ7

Principal investigator: prof. Maciej Wojciech Bagiński

Politechnika Gdańska, Wydział Chemiczny

Synthesis and biological activity evaluation of new hybrid derivatives of tacrine and melatonin as potential cholinester...

Call: OPUS 2 , Panel: ST5

Principal investigator: dr Anna Zawadzka

Uniwersytet Warszawski, Wydział Chemii

Development of dual immuno-oligo- biosensors for monitoring and controlling of the metastatic colorectal cancer and inve...

Call: OPUS 25 , Panel: ST4

Principal investigator: dr hab. Magdalena Stobiecka

Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, Instytut Biologii

Investigating the mechanisms of CD20 downregulation triggered by tyrosine kinase inhibitors in Philadelphia chromosome-p...

Call: PRELUDIUM 22 , Panel: NZ5

Principal investigator: Krzysztof Domka

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

Understanding the contribution of immunoproteasome activation to the neuropathic pain development.

Call: OPUS 25 , Panel: NZ7

Principal investigator: dr Natalia Eleonora Małek-Chudzik

Politechnika Wrocławska

Search for novel IKK-β inhibitors in the context of diseases with neuroinflammatory origin – structure-based drug design...

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Emilia Aleksandra Sługocka

Uniwersytet Jagielloński, Collegium Medicum

Targeting Energy Metabolism for Precision Cancer Therapy: Novel Inhibitors of LDH-A and PDK1 as Potential Strategies to ...

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Marika Anna Frańczak

Gdański Uniwersytet Medyczny, Wydział Lekarski

The design and development of the peptide inhibitors library targeting Zn(II)-binding site of matrix metalloproteinases ...

Call: PRELUDIUM 22 , Panel: ST5

Principal investigator: Paulina Alicja Potok

Uniwersytet Wrocławski, Wydział Chemii

Endothelial bioenergetics as a novel target for vascular protection – unveiling the mitochondrial mechanisms of lipid-lo...

Call: PRELUDIUM 22 , Panel: NZ5

Principal investigator: dr Alicja Małgorzata Braczko

Gdański Uniwersytet Medyczny, Wydział Lekarski

Computational alchemy and experimental validation: a hybrid approach for designing new antimicrobial peptides

Call: PRELUDIUM 22 , Panel: NZ1

Principal investigator: Piotr Maciej Chyży

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Multiparameter analysis of co-inhibitory and co-stimulatory immune checkpoints and their role in the induction of immuno...

Call: PRELUDIUM 22 , Panel: NZ6

Principal investigator: Dorota Suszczyk

Uniwersytet Medyczny w Lublinie

Designing Active Inhibitors of SARS-CoV-2 Methyltransferases

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Alex Jun Matsuda

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

New applications of non-conventional nonempirical methodologies for the analysis of catalytic and inhibitory properties ...

Call: OPUS 25 , Panel: ST4

Principal investigator: dr Edyta Dyguda-Kazimierowicz

Politechnika Wrocławska

Efektywność nowatorskiej terapii inhibitorami JAK u pacjentów z reumatoidalnym zapaleniem stawów w odniesieniu do profil...

Call: PRELUDIUM 22 , Panel: NZ5

Principal investigator: Sylwia Anna Biały

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

Construction of Candida famata flavinogenic yeast strains with improved ability to produce riboflavin in medium with lig...

Call: PRELUDIUM 22 , Panel: NZ1

Principal investigator: Dominik Marek Wojdyła

Uniwersytet Rzeszowski, Kolegium Nauk Przyrodniczych

Feel the chemistry if you're close enough - proximity-induced SuFEx ligation for mRNA biology and medicine

Call: OPUS 25 , Panel: ST5

Principal investigator: prof. Jacek Jemielity

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Development of novel anti-cancer immunotherapy against mesothelioma comprising of oncolytic adenovirus vectors armed wit...

Call: SONATA 18 , Panel: NZ7

Principal investigator: dr Łukasz Kuryk

Narodowy Instytut Zdrowia Publicznego PZH - Państwowy Instytut Badawczy

Development of a cell-based assay for screening of SARS-CoV-2 PLpro inhibitors

Call: SONATA 18 , Panel: NZ6

Principal investigator: dr Wioletta Katarzyna Rut

Politechnika Wrocławska

Effects of tyrosine kinase inhibitors on Syk pathway in eNOS-based platelet subpopulations and on endothelial barrier in...

Call: POLONEZ BIS 3 , Panel: NZ7

Principal investigator: dr hab. Aneta Iwona Radziwon-Balicka

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

Identification of key structural elements of immunomodulatory proteins - inhibitors of antigenic peptide transporter TAP...

Call: SONATA 18 , Panel: NZ7

Principal investigator: dr Natalia Anna Karska

Uniwersytet Gdański, Wydział Chemii

The role of diet in the development of autoimmune diseases - new interleukin 15 inhibitors among dietary polyphenols and...

Call: SONATA 18 , Panel: NZ9

Principal investigator: dr Barbara Joanna Żyżyńska-Granica

Warszawski Uniwersytet Medyczny

Computational deciphering of pro-ferroptotic cell death protein machinery as a fundamental step in the search for therap...

Call: SONATA BIS 12 , Panel: ST4

Principal investigator: dr hab. Karolina Anna Mikulska-Rumińska

Uniwersytet Mikołaja Kopernika w Toruniu, Wydział Fizyki, Astronomii i Informatyki Stosowanej

Histone demethylase inhibitors as chemosensitivity modulators in the treatment of head and neck squamous cell carcinoma

Call: PRELUDIUM 21 , Panel: NZ7

Principal investigator: Dawid Dariusz Dorna

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Use of comparative oncology approach to dissect the PD-1 intrinsic signalling in osteosarcoma. Can dog be the key for ne...

Call: PRELUDIUM 21 , Panel: NZ1

Principal investigator: Katarzyna Joanna Dziubek

Uniwersytet Gdański, Międzynarodowe Centrum Badań nad Szczepionkami Przeciwnowotworowymi

Pharmacogenomics of SGLT2 inhibitors - investigating the role of empagliflozin in epigenetic modification of non-coding ...

Call: PRELUDIUM 21 , Panel: NZ7

Principal investigator: Anna Nowak-Szwed

Warszawski Uniwersytet Medyczny

The effects of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors on changes in selected epigenetic mechan...

Call: PRELUDIUM 21 , Panel: NZ7

Principal investigator: Agnieszka Magdalena Woźniak

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Two-component preparations in the treatment of infections caused by pathogenic microorganisms

Call: SONATA 17 , Panel: NZ7

Principal investigator: dr Katarzyna Szałapata

Uniwersytet Marii Curie-Skłodowskiej w Lublinie, Wydział Biologii i Biotechnologii

Molecular determinants of input specificity in plasticity phenomena at GABAergic synapses in the hippocampus

Call: OPUS 22 , Panel: NZ4

Principal investigator: prof. Jerzy Władysław Mozrzymas

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu

SELECTIVE REGULATION OF RAB GTPASES BY TARGETING PROTEIN-PROTEIN INTERACTIONS BETWEEN RABS AND REGULATORY PROTEINS

Call: PRELUDIUM BIS 3 , Panel: ST4

Principal investigator: dr hab. Katarzyna Magdalena Błażewska

Politechnika Łódzka, Wydział Chemiczny

Combinatorial targeting of non-genetic sources of cell-to-cell heterogeneity to overcome fractional killing of cancer ce...

Call: SONATA 17 , Panel: NZ3

Principal investigator: dr Jarosław Walczak

Instytut Podstawowych Problemów Techniki Polskiej Akademii Nauk

Radiosensitization by the combined use of modified nucleosides and inhibitors of DNA repair to improve the efficacy of r...

Call: SONATA 17 , Panel: ST4

Principal investigator: dr Magdalena Danuta Zdrowowicz-Żamojć

Uniwersytet Gdański, Wydział Chemii

Structure-guided design of histone demethylase inhibitors for cancer therapy.

Call: SONATA 17 , Panel: NZ7

Principal investigator: dr Piotr Henryk Małecki

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk