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The influence of metabolic pathway inhibitors on the development and quality of bovine embryos produced in vitro.

2012/05/B/NZ9/03349

Keywords

Descriptors

  • NZ3_13: Biologia rozwoju zwierząt
  • NZ3_8: Komórki macierzyste
  • NZ3_1: Biologia komórki

Panel

NZ9 – Fundamentals of applied life sciences and biotechnology: agricultural, forestry, horticulture, animal production and fishery, food and nutrition sciences, industrial biosciences, environmental biotechnology and remediation

Host institution

Uniwersytet Przyrodniczy w Poznaniu, Wydział Medycyny Weterynaryjnej i Nauk o Zwierzętach

Voivodeship: wielkopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Dorota Marta Cieślak

Number of co-investigators in the project: 5

Call

OPUS 3 – announced on 2012-03-15

Amount awarded
671 596 PLN
Project start date
2013-03-25
Project end date
2017-03-24
Project duration
48 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Analityczna waga laboratoryjna. Cost: 10 000 PLN
  2. Doposażenie mikroskopu Leica AM6000.
  3. Miernik pH S220-Kit.
  4. Mieszadło hotMix1 z zestawem akcesoriów.
  5. Wirówka Cytologiczna Cytospin 4, Elektro Med. Cost: 45 000 PLN
  6. Wirówka z chłodzeniem (0stC) Eppendorf 5418R. Cost: 24 000 PLN
  7. kamera z monitorem zewnętrzym (dodatkowe wyposażenie istniejacego stereoskopowego mikroskopu Olympus SZX-7). Cost: 9 000 PLN

Information in the final report

Publication in academic press/journals (2)

  1. Inhibitor mediated WNT and MEK/ERK signalling affects apoptosis and the expression of quality related genes in bovine in vitro obtained blastocysts

    Authors:
    Madeja ZE, Warzych E, Pawlak P, Lechniak D.
    Academic press:
    Biochem Biophys Res Commun (year: 2019, volume: 510 (3), pages: 403-408), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbrc.2019.01.113 – link to the publication

  2. WNT signalling supported by MEK/ERK inhibition is essential to maintain pluripotency in bovine preimplantation embryo

    Authors:
    Ewelina Warzych, Piotr Pawlak, Dorota Lechniak, Zofia Eliza Madeja
    Status:
    Accepted for publication

Articles in post-conference publications (4)

  1. Genetic factors regulating cell lineage specification and pluripotency maintenance at the early stage of bovine embryonic development

    Authors:
    Madeja ZE, Pawlak P, Warzych-Plejer E, Cieślak D
    Conference:
    Polski Kongres Genetyki (year: 2016, pages: 120), Publisher: Polskie Towarzystwo Genetyczne
    Date:
    conference 19-22.06.2016
    Status:
    Published

  2. Wpływ inhibitorów ścieżek różnicowania komórkowego (system 2i) na jakość blastocyst bydła - indeks apoptotyczny i całkowita liczba blastomerów.

    Authors:
    Hryniewicz K., Warzych E., Madeja Z.E., Perkowska A., Lechniak-Cieślak D.
    Conference:
    VII Zjazd Towarzystwa Biologii Rozrodu (year: 2014, pages: 142), Publisher: Towarzystwo Biologii Rozrodu
    Date:
    conference 11-13.09.2014
    Status:
    Published

  3. Quality of bovine blastocysts produced in vitro with the 3i/2i inhibitor systems

    Authors:
    Warzych Ewelina, Madeja Zofia, Pawlak Piotr, Lechniak-Cieslak Dorota
    Conference:
    Epigenetic and Periconcept Environment (year: 2016, pages: 77), Publisher: COST
    Date:
    conference 26-29.09.2016
    Status:
    Published

  4. The effect of 2i inhibitor system on pluripotency marker genes expression in bovine blastocysts.

    Authors:
    Hryniewicz K., Madeja Z., Lechniak D.
    Conference:
    The 2014 Regenerative Medicine Event: Stem Cell Reprogramming (year: 2014, pages: -), Publisher: Euroscicon
    Date:
    conference 02.06.2014
    Status:
    Published

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