Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Design, synthesis and biological evaluation of Steroid Sulfatase Inhibitors based on organophosphorus compounds.

2011/03/D/NZ7/03985

Keywords:

medicinal chemistry organophosphorus chemistry steroid sulfatase inhibitors molecular modeling breast cancer

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • ST5_16:
  • ST5_23:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

POLITECHNIKA GDAŃSKA

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Sebastian Demkowicz 

Number of co-investigators in the project: 3

Call: SONATA 2 - announced on 2011-09-15

Amount awarded: 333 140 PLN

Project start date (Y-m-d): 2012-08-06

Project end date (Y-m-d): 2015-08-05

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Zestaw komputerowy z drukarką.
  2. Aparat do pomiaru temperatury topnienia SMP30 (3 700 PLN)
  3. Waga analityczna Ohaus PA214C/1 (4 000 PLN)
  4. Membranowa pompa próżniowa N842.3FT.18, 34l/min (15 000 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  1. Phosphate tricyclic coumarin analogs as steroid sulfatase inhibitors: synthesis and biological activity
    Authors:
    Witold Kozak, Mateusz Daśko, Maciej Masłyk, Jerzy S. Pieczykolan, Bartłomiej Gielniewski, Janusz Rachon, Sebastian Demkowicz
    Academic press:
    RSC Advances (rok: 2014, tom: 4, strony: 44350-44358), Wydawca: ROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
    Status:
    Published
    DOI:
    10.1039/c4ra07135b - link to the publication
  2. Steroid sulfatase inhibitors based on phosphate and thiophosphate flavone analogs
    Authors:
    Witold Kozak, Mateusz Daśko,Maciej Masłyk, Konrad Kubiński, Janusz Rachon, Sebastian Demkowicz
    Academic press:
    Drug Development Research (rok: 2015, tom: 76, strony: 450-462), Wydawca: WILEY-BLACKWELL
    Status:
    Published
    DOI:
    10.1002/ddr.21281 - link to the publication
  3. Synthesis and biological evaluation of fluorinated 3-phenylcoumarin-7-O-sulfamate derivatives as steroid sulfatase inhibitors
    Authors:
    Sebastian Demkowicz, Mateusz Daśko, Witold Kozak, Katarzyna Krawczyk, Dariusz Witt, Maciej Masłyk, Konrad Kubiński, Janusz Rachon
    Academic press:
    Chemical Biology & Drug Design (rok: 2016, tom: 87, strony: 233-238), Wydawca: WILEY-BLACKWELL
    Status:
    Published
    DOI:
    10.1111/cbdd.12652 - link to the publication
  4. Phosphate and thiophosphate biphenyl analogs as steroid sulfatase inhibitors
    Authors:
    Sebastian Demkowicz, Witold Kozak, Mateusz Daśko, Maciej Masłyk, Konrad Kubiński, Janusz Rachon
    Academic press:
    Drug Development Research (rok: 2015, tom: 76, strony: 94-104), Wydawca: WILEY-BLACKWELL
    Status:
    Published
    DOI:
    10.1111/ddr.21245 - link to the publication
  5. Synthesis and biological evaluation of thiophosphate tricyclic coumarin derivatives as steroid sulfatase inhibitors
    Authors:
    Sebastian Demkowicz, Witold Kozak, Mateusz Daśko, Maciej Masłyk, Bartłomiej Gielniewski, Janusz Rachon
    Academic press:
    Journal of Asian Natural Products Research (rok: 2015, tom: -, strony: -), Wydawca: TAYLOR & FRANCIS LTD
    Status:
    Published
    DOI:
    10.1080/10286020.2015.1054815 - link to the publication
  6. Synthesis and steroid sulfatase inhibitory activities of Nalkanoyl tyramine phosphates and thiophosphates
    Authors:
    Witold Kozak, Mateusz Daśko, Agnieszka Wołos, Maciej Masłyk, Konrad Kubiński, Andrzej Składanowski, Majus Misiak, Janusz Rachon, Sebastian Demkowicz
    Academic press:
    RSC Advances (rok: 2015, tom: 5, strony: 32594-32603), Wydawca: ROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
    Status:
    Published
    DOI:
    10.1039/c5ra01614b - link to the publication
  7. Synthesis of bicoumarin thiophosphate derivatives as steroid sulfatase inhibitors
    Authors:
    Sebastian Demkowicz, Witold Kozak, Mateusz Daśko, Maciej Masłyk, Bartłomiej Gielniewski, Janusz Rachon
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2015, tom: 101, strony: 358-366), Wydawca: ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2015.06.051 - link to the publication

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