Novel peptide inhibitors of dipeptidyl peptidase IV (DPP IV) as novel approach for diabetes type 2 and inflammatory bowel diseases treatment
2013/11/N/NZ7/02354
Keywords
Descriptors
- NZ7_14: Farmacja, farmakoterapia, farmakologia
Panel
NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution
Uniwersytet Medyczny w Łodzi, Wydział Lekarski
Voivodeship: łódzkie
Principal investigator (from the host institution)
Number of co-investigators in the project: 3
Call
PRELUDIUM 6 – announced on 2013-09-16
- Amount awarded
- 135 187 PLN
- Project start date
- 2014-09-22
- Project end date
- 2018-09-21
- Project duration
- 48 months (the same as in the proposal)
- Project status
- Project settled
Information in the final report
Publication in academic press/journals (2)
-
Novel peptide inhibitor of dipeptidyl peptidase IV (Tyr-Pro-D-Ala-NH2) with anti-inflammatory activity in the mouse models of colitis
- Authors:
- Maciej Sałaga, Agata Binienda, Piotr Drączkowski, Piotr Kosson, Radzisław Kordek, Krzysztof Jóżwiak, Jakub Fichna
- Academic press:
- Peptides (year: 2018, volume: 108, pages: 34-45), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/J.PEPTIDES.2018.08.011 – link to the publication
-
New Peptide Inhibitor of Dipeptidyl Peptidase IV, EMDB-1 Extends the Half-Life of GLP-2 and Attenuates Colitis in Mice after Topical Administration
- Authors:
- Maciej Sałaga, Anna Mokrowiecka, Marta Zielińska, Ewa Małecka-Panas, Radzisław Kordek, Elżbieta Kamysz, Jakub Fichna
- Academic press:
- Journal of Pharmacology and Experimental Therapeutics (year: 2017, volume: 363, pages: 92-103), Publisher: American Society for Pharmacology and Experimental Therapeutics
- Status:
- Published
- DOI:
- 10.1124/jpet.117.242586 – link to the publication
Articles in post-conference publications (1)
-
NEW, PEPTIDE INHIBITOR OF DIPEPTIDYL PEPTIDASE IV, EMDB-1 ATTENUATES COLITIS IN MICE AFTER TOPICAL ADMINISTRATION
- Authors:
- Maciej Salaga, Paula Mosinska, Hubert Zatorski, Marta Zielinska, Jakub Fichna
- Conference:
- 24th United European Gastroenterology Week (year: 2016, pages: 100), Publisher: United European Gastroenterology
- Date:
- conference 15-19.10
- Status:
- Published