Design and synthesis of phosphoroorganic antagonists of BIR domain of apoptosis inhibitor proteins (IAP)
2014/13/N/ST5/01582
Keywords
Descriptors
- ST5_23: Chemia organiczna
- ST5_16: Chemia biologiczna
Panel
ST5 – Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering
Host institution
Politechnika Wrocławska, Wydział Chemiczny
Voivodeship: dolnośląskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 2
Call
PRELUDIUM 7 – announced on 2014-03-17
- Amount awarded
- 100 000 PLN
- Project start date
- 2015-03-18
- Project end date
- 2017-06-17
- Project duration
- 27 months (the same as in the proposal)
- Project status
- Project settled
Information in the final report
Publication in academic press/journals (1)
-
Structure-based design, synthesis, and evaluation of the biological activity of novel phosphoroorganic small molecule IAP antagonists
- Authors:
- Agnieszka Łupicka-Słowik, Mateusz Psurski, Renata Grzywa, Monika Cuprych, Jarosław Ciekot, Waldemar Goldeman, Elżbieta Wojaczyńska, Jacek Wojaczyński, Józef Oleksyszyn, Marcin Sieńczyk
- Academic press:
- Investigational New Drugs (year: 2020, volume: 38(5), pages: 1350-1364), Publisher: Springer
- Status:
- Published
- DOI:
- 10.1007/s10637-020-00923-4 – link to the publication
Articles in post-conference publications (2)
-
Small-molecule phosphoroorganic antagonists of inhibitor of apoptosis proteins: synthesis and their potential activity studies.
- Authors:
- Łupicka-Słowik A., Grzywa R., Olszewski T., Lefebvre N., Goldeman W., Psurski M., Ciekot J., Dawidczyk M., Oleksyszyn J., Sieńczyk M.
- Conference:
- 24th Polish Peptide Symposium (year: 2017, pages: 106), Publisher: University of Gdańsk
- Date:
- conference 03.09-07.09
- Status:
- Published
-
The design and synthesis of novel phosphororganic antagonists of inhibitor of apoptosis proteins (IAPs)
- Authors:
- Agnieszka Łupicka-Słowik, Renata Grzywa, Tomasz Olszewski, Waldemar Goldeman, Jolanta Sum, Sabina Myśliwiec, Józef Oleksyszyn, Marcin Sieńczyk
- Conference:
- 23 Polish Peptide Symposium Spala 2015 (year: 2015, pages: 143), Publisher: Lodz University of Technology
- Date:
- conference 30.08 - 03.09
- Status:
- Published