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Information on the principal investigator and host institution

Information of the project and the call

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Design and synthesis of phosphoroorganic antagonists of BIR domain of apoptosis inhibitor proteins (IAP)

2014/13/N/ST5/01582

Keywords:

phosphoroorganic compounds apoptosis inhibotor proteins IAP apoptosis

Descriptors:

  • ST5_23:
  • ST5_16:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Politechnika Wrocławska, Wydział Chemiczny

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Agnieszka Łupicka-Słowik 

Number of co-investigators in the project: 2

Call: PRELUDIUM 7 - announced on 2014-03-17

Amount awarded: 100 000 PLN

Project start date (Y-m-d): 2015-03-18

Project end date (Y-m-d): 2017-06-17

Project duration:: 27 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (1)
  • Articles in post-conference publications (2)
  1. Structure-based design, synthesis, and evaluation of the biological activity of novel phosphoroorganic small molecule IAP antagonists
    Authors:
    Agnieszka Łupicka-Słowik, Mateusz Psurski, Renata Grzywa, Monika Cuprych, Jarosław Ciekot, Waldemar Goldeman, Elżbieta Wojaczyńska, Jacek Wojaczyński, Józef Oleksyszyn, Marcin Sieńczyk
    Academic press:
    Investigational New Drugs (rok: 2020, tom: 38(5), strony: 1350-1364), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s10637-020-00923-4 - link to the publication
  1. Small-molecule phosphoroorganic antagonists of inhibitor of apoptosis proteins: synthesis and their potential activity studies.
    Authors:
    Łupicka-Słowik A., Grzywa R., Olszewski T., Lefebvre N., Goldeman W., Psurski M., Ciekot J., Dawidczyk M., Oleksyszyn J., Sieńczyk M.
    Conference:
    24th Polish Peptide Symposium (rok: 2017, ), Wydawca: University of Gdańsk
    Data:
    konferencja 03.09-07.09
    Status:
    Published
  2. The design and synthesis of novel phosphororganic antagonists of inhibitor of apoptosis proteins (IAPs)
    Authors:
    Agnieszka Łupicka-Słowik, Renata Grzywa, Tomasz Olszewski, Waldemar Goldeman, Jolanta Sum, Sabina Myśliwiec, Józef Oleksyszyn, Marcin Sieńczyk
    Conference:
    23 Polish Peptide Symposium Spala 2015 (rok: 2015, ), Wydawca: Lodz University of Technology
    Data:
    konferencja 30.08 - 03.09
    Status:
    Published

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