Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Novel dual CYP17A1 and AKR1C3 inhibitors for studying the mechanism of resistance in prostate cancer

2020/39/D/NZ7/00572

Keywords:

prostate cancer medicinal chemistry enzyme inhibition

Descriptors:

  • NZ7_014:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny w Lublinie

woj. lubelskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Tomasz Marcin Wróbel 

Number of co-investigators in the project: 4

Call: SONATA 16 - announced on 2020-09-15

Amount awarded: 695 400 PLN

Project start date (Y-m-d): 2021-10-01

Project end date (Y-m-d): 2025-09-30

Project duration:: 48 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  1. Exploring the Potential of Sulfur Moieties in Compounds Inhibiting Steroidogenesis
    Authors:
    Tomasz M. Wróbel, Katyayani Sharma, Iole Mannella, Simonetta Oliaro-Bosso, Patrycja Nieckarz,Therina Du Toit, Clarissa Daniela Voegel, Maria Natalia Rojas Velazquez, Jibira Yakubu, Anna Matveeva, Søren Therkelsen, Flemming Steen Jørgensen, Amit V. Pandey, Agnese C. Pippione, Marco L. Lolli, Donatella Boschi and Fredrik Björkling
    Academic press:
    Biomolecules (rok: 2023, tom: 13, strony: 1349), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom13091349 - link to the publication
  2. Synthesis and Structure–Activity Relationships of Novel Non-Steroidal CYP17A1 Inhibitors as Potential Prostate Cancer Agents
    Authors:
    Tomasz M. Wróbel, Oksana Rogova, Katyayani Sharma, Maria Natalia Rojas Velazquez, Amit V. Pandey, Flemming Steen Jørgensen, Frederic S. Arendrup, Kasper L. Andersen, Fredrik Björkling
    Academic press:
    Biomolecules (rok: 2022, tom: 12, strony: 165), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom12020165 - link to the publication
  3. Non-steroidal CYP17A1 Inhibitors: Discovery and Assessment
    Authors:
    Tomasz M. Wróbel, Flemming Steen Jørgensen, Amit V. Pandey, Angelika Grudzińska, Katyayani Sharma, Jibira Yakubu, and Fredrik Björkling
    Academic press:
    Journal of Medicinal Chemistry (rok: 2023, tom: 66, strony: 6542), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.jmedchem.3c00442 - link to the publication
  4. Synthesis and Structure–Activity Relationships of Novel Non-Steroidal CYP17A1 Inhibitors as Potential Prostate Cancer Agents
    Authors:
    Tomasz M. Wróbel, Oksana Rogova, Katyayani Sharma, Maria Natalia Rojas Velazquez, Amit V. Pandey, Flemming Steen Jørgensen, Frederic S. Arendrup, Kasper L. Andersen, Fredrik Björkling
    Academic press:
    Biomolecules (rok: 2022, tom: 12, strony: 165), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom12020165 - link to the publication