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In vitro/in vivo characteristics of hydrophilic matrix containing phosphodiesterase-5 inhibitors.

2012/07/D/NZ7/01673

Keywords

Descriptors

  • NZ7_14: Farmacja, farmakoterapia, farmakologia

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Anna Krupa

Number of co-investigators in the project: 7

Call

SONATA 4 – announced on 2012-09-15

Amount awarded
382 741 PLN
Project start date
2013-07-11
Project end date
2017-07-10
Project duration
48 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. 8-miejscowa łaźnia wodna do badań dostępności farmaceutycznej ze stałych form leków wg FP IX. Cost: 90 000 PLN
  2. Laptop Lenovo. Cost: 5 442 PLN
  3. Pakiet Microsoft Office. Cost: 302 PLN
  4. Projektor multimedialny. Cost: 3 044 PLN
  5. Uchwyt do kuwet.

Information in the final report

Publication in academic press/journals (6)

  1. In vitro and in vivo behavior of ground tadalafil hot-melt extrudates: How the carrier material can effectively assure rapid or controlled drug release

    Authors:
    Anna Krupa, Oriane Cantin, Beata Strach, Elżbieta Wyska, Zbisław Tabor, Juergen Siepmann, Andrzej Wróbel, Renata Jachowicz
    Academic press:
    International Journal of Pharmaceutics (year: 2017, volume: 528, pages: 498-510), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ijpharm.2017.05.057 – link to the publication

  2. High-Energy Ball Milling as Green Process to Vitrify Tadalafil and Improve Bioavailability

    Authors:
    Anna Krupa, Marc Descamps, Jean-Francois Willart, Beata Strach, Elżbieta Wyska, Renata Jachowicz, Florence Danede
    Academic press:
    Molecular Pharmaceutics (year: 2016, volume: 13, pages: 3891-3902), Publisher: American Chemical Society (ACS)
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.6b00688 – link to the publication

  3. Physicochemical Properties of Bosentan and Selected PDE-5 Inhibitors in the Design of Drugs for Rare Diseases

    Authors:
    Anna Krupa, Dorota Majda, Włodzimierz Mozgawa, Jakub Szlęk, Renata Jachowicz
    Academic press:
    AAPS PharmSciTech (year: 2017, volume: 18, pages: 1318-1331), Publisher: American Association of Pharmaceutical Scientists (AAPS) - Springer
    Status:
    Published
    DOI:
    10.1208/s12249-016-0599-7 – link to the publication

  4. The impact of polymers on 3D microstructure and controlled release of sildenafil citrate from hydrophilic matrices

    Authors:
    Anna Krupa, Zbisław Tabor, Jacek Tarasiuk, Beata Strach, Krzysztof Pociecha, Elżbieta Wyska, Sebastian Wroński, Ewelina Łyszczarz, Renata Jachowicz
    Academic press:
    European Journal of Pharmaceutical Sciences (year: 2018, volume: 119, pages: 234-243), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejps.2018.04.023 – link to the publication

  5. High energy ball milling and supercritical carbon dioxide impregnation as co-processing methods to improve dissolution of tadalafil

    Authors:
    Anna Krupa, Marc Descamps, Jean-Francois Willart, Renata Jachowicz, Florence Danede
    Academic press:
    European Journal of Pharmaceutical Sciences (year: 2016, volume: 95, pages: 130-137), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejps.2016.05.007 – link to the publication

  6. Sensitive and precise HPLC method with back-extraction clean-up step for the determination of sildenafil in rat plasma and its application to a pharmacokinetic study

    Authors:
    Beata Strach, Elżbieta Wyska, Krzysztof Pociecha, Anna Krupa, Renata Jachowicz
    Academic press:
    Biomedical Chromatography (year: 2015, volume: 29, pages: 1559-1566), Publisher: John Wiley & Sons Ltd
    Status:
    Published
    DOI:
    10.1002/bmc.3459 – link to the publication

Articles in post-conference publications (12)

  1. Hydration kinetics and sorption isotherm of comilled solid dispersion composed of tadalafil and Soluplus

    Authors:
    Piotr Nowak, Anna Krupa, Karol Kubat, Hubert Harańczyk, Renata Jachowicz
    Conference:
    2nd European Conference on Pharmaceutics (year: 2017, pages: 46024), Publisher: APV
    Date:
    conference 03-04.04
    Status:
    Published

  2. Solid dispersions tadalafil-Soluplus formed by high-energy ball milling. Impact of process parameters.

    Authors:
    Anna Krupa, Dorota Majda, Katarzyna Dziewic, Renata Jachowicz
    Conference:
    6th FIP Pharmaceutical Sciences World Congress (PSWC) (year: 2017, pages: 1), Publisher: Intrenational Pharmaceutical Federation (FIP)
    Date:
    conference 21-24.05
    Status:
    Published

  3. The impact of polyols on tadalafil release from melted hydrophilic matrices

    Authors:
    Anna Krupa, Dorota Majda, Renata Jachowicz
    Conference:
    9th Polish-German Symposium on Pharmaceutical Sciences (year: 2017, pages: 146-147), Publisher: Jagiellonian University Medical College, Polish Academy of Science, Polish Pharmaceutical Society
    Date:
    conference 26-27.05
    Status:
    Published

  4. Thermal stability of selected phosphodiesterase-5 inhibitors

    Authors:
    Anna Krupa, Dorota Majda, Renata Jachowicz
    Conference:
    9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology (year: 2014, pages: 2), Publisher: APV Mainz, Niemcy
    Date:
    conference 31.03-03.04.2014
    Status:
    Published

  5. Heuristic modeling of dissolution rate of BCS class II APIs from solid dispersion systems

    Authors:
    Jakub Szlęk, Anna Krupa, Renata Jachowicz, Aleksander Mendyk
    Conference:
    9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology (year: 2014, pages: 2), Publisher: APV, Mainz Niemcy
    Date:
    conference 31.03-04.04.2014
    Status:
    Published

  6. Bioavailability of tadalafil upon co-processing with Soluplus: Importance of the manufacturing procedure

    Authors:
    Anna Krupa, Beata Strach, Elżbieta Wyska, Oriane Cantin, Juergen Siepmann, Renata Jachowicz
    Conference:
    2nd European Conference on Pharmaceutics (year: 2017, pages: 46024), Publisher: APV
    Date:
    conference 03-04.04
    Status:
    Published

  7. Empirical modeling of dissolution profile of poorly soluble drugs from solid dispersions

    Authors:
    Jakub Szlęk, Renata Jachowicz, Aleksander Mendyk, Anna Krupa
    Conference:
    9th Polish-German Symposium on Pharmaceutical Sciences (year: 2017, pages: 170-171), Publisher: Jagiellonian University Medical College, Polish Academy of Science, Polish Pharmaceutical Society
    Date:
    conference 26-27.05
    Status:
    Published

  8. HME and supercritical carbon dioxide impregnation as co-processing methods to improve the dissolution of tadalafil

    Authors:
    Anna Krupa, Oriane Cantin, Juergen Siepmann, Renata Jachowicz
    Conference:
    10th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology (year: 2016, pages: 51), Publisher: APV, Mainz, Niemcy
    Date:
    conference 04-07.04.2016
    Status:
    Published

  9. Hot melt extruded hydrophilic matrices for improved tadalafil dissolution

    Authors:
    Anna Krupa, Oriane Cantin, Juergen Siepmann, Renata Jachowicz
    Conference:
    8th Polish-German Symposium on Pharmaceutical Sciences (year: 2015, pages: PT-08), Publisher: Christian-Albrechts-Univeristat zu Kiel
    Date:
    conference 29-30.05.2015
    Status:
    Published

  10. Solid suspensions of tadalafil in Kollidon VA 64 Fine obtained by supercritical carbon dioxide processing

    Authors:
    Anna Krupa, Dorota Majda, Joanna Kacperczyk, Renata Jachowicz
    Conference:
    Poorly Soluble Drugs Workshop (year: 2014, pages: 1), Publisher: APGI
    Date:
    conference 02.07.0214
    Status:
    Published

  11. High Energy Milling and Supercritical Carbon Dioxide Impregnation as Co-Processing Methods to Improve Dissolution of Tadalafil

    Authors:
    Anna Krupa, Marc Descamps, Jean-François Willart, Renata Jachowicz, Florence Danède
    Conference:
    6th BBBB - Conference on Pharmaceutical Sciences: Strategies to Improve the Quality and Performance of Modern Drug Delivery Systems (year: 2015, pages: 13), Publisher: EUFEPS
    Date:
    conference 10-12.09.2015
    Status:
    Published

  12. Vitrification of tadalafil by co-milling with Soluplus

    Authors:
    Anna Krupa, Marc Descamps, Jean-François Willart, Florence Danede, Renata Jachowicz
    Conference:
    46th French Conference on Calorimetry and Thermal Analysis (year: 2015, pages: 41), Publisher: AFCAT
    Date:
    conference 20-22.05.2015
    Status:
    Published

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