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Information on the principal investigator and host institution

Information of the project and the call

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In vitro/in vivo characteristics of hydrophilic matrix containing phosphodiesterase-5 inhibitors.

2012/07/D/NZ7/01673

Keywords:

hydrophilic matrix micro-CT PDE-5

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Anna Krupa 

Number of co-investigators in the project: 7

Call: SONATA 4 - announced on 2012-09-15

Amount awarded: 382 741 PLN

Project start date (Y-m-d): 2013-07-11

Project end date (Y-m-d): 2017-07-10

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Laptop Lenovo (5 442 PLN)
  2. Projektor multimedialny (3 044 PLN)
  3. 8-miejscowa łaźnia wodna do badań dostępności farmaceutycznej ze stałych form leków wg FP IX (90 000 PLN)
  4. Pakiet Microsoft Office (302 PLN)
  5. Uchwyt do kuwet.

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (12)
  1. High energy ball milling and supercritical carbon dioxide impregnation as co-processing methods to improve dissolution of tadalafil
    Authors:
    Anna Krupa, Marc Descamps, Jean-Francois Willart, Renata Jachowicz, Florence Danede
    Academic press:
    European Journal of Pharmaceutical Sciences (rok: 2016, tom: 95, strony: 130-137), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejps.2016.05.007 - link to the publication
  2. In vitro and in vivo behavior of ground tadalafil hot-melt extrudates: How the carrier material can effectively assure rapid or controlled drug release
    Authors:
    Anna Krupa, Oriane Cantin, Beata Strach, Elżbieta Wyska, Zbisław Tabor, Juergen Siepmann, Andrzej Wróbel, Renata Jachowicz
    Academic press:
    International Journal of Pharmaceutics (rok: 2017, tom: 528, strony: 498-510), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ijpharm.2017.05.057 - link to the publication
  3. Physicochemical Properties of Bosentan and Selected PDE-5 Inhibitors in the Design of Drugs for Rare Diseases
    Authors:
    Anna Krupa, Dorota Majda, Włodzimierz Mozgawa, Jakub Szlęk, Renata Jachowicz
    Academic press:
    AAPS PharmSciTech (rok: 2017, tom: 18, strony: 1318-1331), Wydawca: American Association of Pharmaceutical Scientists (AAPS) - Springer
    Status:
    Published
    DOI:
    10.1208/s12249-016-0599-7 - link to the publication
  4. The impact of polymers on 3D microstructure and controlled release of sildenafil citrate from hydrophilic matrices
    Authors:
    Anna Krupa, Zbisław Tabor, Jacek Tarasiuk, Beata Strach, Krzysztof Pociecha, Elżbieta Wyska, Sebastian Wroński, Ewelina Łyszczarz, Renata Jachowicz
    Academic press:
    European Journal of Pharmaceutical Sciences (rok: 2018, tom: 119, strony: 234-243), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejps.2018.04.023 - link to the publication
  5. Sensitive and precise HPLC method with back-extraction clean-up step for the determination of sildenafil in rat plasma and its application to a pharmacokinetic study
    Authors:
    Beata Strach, Elżbieta Wyska, Krzysztof Pociecha, Anna Krupa, Renata Jachowicz
    Academic press:
    Biomedical Chromatography (rok: 2015, tom: 29, strony: 1559-1566), Wydawca: John Wiley & Sons Ltd
    Status:
    Published
    DOI:
    10.1002/bmc.3459 - link to the publication
  6. High-Energy Ball Milling as Green Process to Vitrify Tadalafil and Improve Bioavailability
    Authors:
    Anna Krupa, Marc Descamps, Jean-Francois Willart, Beata Strach, Elżbieta Wyska, Renata Jachowicz, Florence Danede
    Academic press:
    Molecular Pharmaceutics (rok: 2016, tom: 13, strony: 3891-3902), Wydawca: American Chemical Society (ACS)
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.6b00688 - link to the publication
  1. Hydration kinetics and sorption isotherm of comilled solid dispersion composed of tadalafil and Soluplus
    Authors:
    Piotr Nowak, Anna Krupa, Karol Kubat, Hubert Harańczyk, Renata Jachowicz
    Conference:
    2nd European Conference on Pharmaceutics (rok: 2017, ), Wydawca: APV
    Data:
    konferencja 03-04.04
    Status:
    Published
  2. Thermal stability of selected phosphodiesterase-5 inhibitors
    Authors:
    Anna Krupa, Dorota Majda, Renata Jachowicz
    Conference:
    9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology (rok: 2014, ), Wydawca: APV Mainz, Niemcy
    Data:
    konferencja 31.03-03.04.2014
    Status:
    Published
  3. HME and supercritical carbon dioxide impregnation as co-processing methods to improve the dissolution of tadalafil
    Authors:
    Anna Krupa, Oriane Cantin, Juergen Siepmann, Renata Jachowicz
    Conference:
    10th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology (rok: 2016, ), Wydawca: APV, Mainz, Niemcy
    Data:
    konferencja 04-07.04.2016
    Status:
    Published
  4. Heuristic modeling of dissolution rate of BCS class II APIs from solid dispersion systems
    Authors:
    Jakub Szlęk, Anna Krupa, Renata Jachowicz, Aleksander Mendyk
    Conference:
    9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology (rok: 2014, ), Wydawca: APV, Mainz Niemcy
    Data:
    konferencja 31.03-04.04.2014
    Status:
    Published
  5. Solid dispersions tadalafil-Soluplus formed by high-energy ball milling. Impact of process parameters.
    Authors:
    Anna Krupa, Dorota Majda, Katarzyna Dziewic, Renata Jachowicz
    Conference:
    6th FIP Pharmaceutical Sciences World Congress (PSWC) (rok: 2017, ), Wydawca: Intrenational Pharmaceutical Federation (FIP)
    Data:
    konferencja 21-24.05
    Status:
    Published
  6. Solid suspensions of tadalafil in Kollidon VA 64 Fine obtained by supercritical carbon dioxide processing
    Authors:
    Anna Krupa, Dorota Majda, Joanna Kacperczyk, Renata Jachowicz
    Conference:
    Poorly Soluble Drugs Workshop (rok: 2014, ), Wydawca: APGI
    Data:
    konferencja 02.07.0214
    Status:
    Published
  7. The impact of polyols on tadalafil release from melted hydrophilic matrices
    Authors:
    Anna Krupa, Dorota Majda, Renata Jachowicz
    Conference:
    9th Polish-German Symposium on Pharmaceutical Sciences (rok: 2017, ), Wydawca: Jagiellonian University Medical College, Polish Academy of Science, Polish Pharmaceutical Society
    Data:
    konferencja 26-27.05
    Status:
    Published
  8. Bioavailability of tadalafil upon co-processing with Soluplus: Importance of the manufacturing procedure
    Authors:
    Anna Krupa, Beata Strach, Elżbieta Wyska, Oriane Cantin, Juergen Siepmann, Renata Jachowicz
    Conference:
    2nd European Conference on Pharmaceutics (rok: 2017, ), Wydawca: APV
    Data:
    konferencja 03-04.04
    Status:
    Published
  9. Hot melt extruded hydrophilic matrices for improved tadalafil dissolution
    Authors:
    Anna Krupa, Oriane Cantin, Juergen Siepmann, Renata Jachowicz
    Conference:
    8th Polish-German Symposium on Pharmaceutical Sciences (rok: 2015, ), Wydawca: Christian-Albrechts-Univeristat zu Kiel
    Data:
    konferencja 29-30.05.2015
    Status:
    Published
  10. Vitrification of tadalafil by co-milling with Soluplus
    Authors:
    Anna Krupa, Marc Descamps, Jean-François Willart, Florence Danede, Renata Jachowicz
    Conference:
    46th French Conference on Calorimetry and Thermal Analysis (rok: 2015, ), Wydawca: AFCAT
    Data:
    konferencja 20-22.05.2015
    Status:
    Published
  11. Empirical modeling of dissolution profile of poorly soluble drugs from solid dispersions
    Authors:
    Jakub Szlęk, Renata Jachowicz, Aleksander Mendyk, Anna Krupa
    Conference:
    9th Polish-German Symposium on Pharmaceutical Sciences (rok: 2017, ), Wydawca: Jagiellonian University Medical College, Polish Academy of Science, Polish Pharmaceutical Society
    Data:
    konferencja 26-27.05
    Status:
    Published
  12. High Energy Milling and Supercritical Carbon Dioxide Impregnation as Co-Processing Methods to Improve Dissolution of Tadalafil
    Authors:
    Anna Krupa, Marc Descamps, Jean-François Willart, Renata Jachowicz, Florence Danède
    Conference:
    6th BBBB - Conference on Pharmaceutical Sciences: Strategies to Improve the Quality and Performance of Modern Drug Delivery Systems (rok: 2015, ), Wydawca: EUFEPS
    Data:
    konferencja 10-12.09.2015
    Status:
    Published

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