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RNA chaperone activity of HIV-2 Gag and nuclocapsid proteins: implications for the design of the new retroviral inhibitors

2011/01/D/NZ1/03478

Keywords

Descriptors

  • NZ1_1: Biologia molekularna

Panel

NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution

Instytut Chemii Bioorganicznej PAN

Voivodeship: wielkopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Katarzyna Pachulska-Wieczorek

Number of co-investigators in the project: 4

Call

SONATA 1 – announced on 2011-03-15

Amount awarded
390 000 PLN
Project start date
2011-12-07
Project end date
2015-06-06
Project duration
42 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Aparat do elektroforezy poziomej w żelu agarozowym. Cost: 1 000 PLN
  2. Aparat do sekwencyjnej elektroforezy pionowej. Cost: 10 000 PLN
  3. Inkubator z wytrząsaniem do prowadzenia hodowli bakteryjnych. Cost: 35 000 PLN
  4. Lampa UV 254/365nm. Cost: 3 000 PLN
  5. komputer z oprogramowaniem.
  6. pompa olejowa. Cost: 11 000 PLN
  7. szafa chłodnicza.

Information in the final report

Publication in academic press/journals (7)

  1. Characterizing the functions of Ty1 Gag and the Gag-derived restriction factor p22/p18

    Authors:
    Pachulska-Wieczorek K, Błaszczyk L, Gumna J, Nishida Y, Saha A, Biesiada M, Garfinkel DJ, Purzycka KJ
    Academic press:
    Mobile Genetic Elements (year: 2016, volume: 6, pages: nie dotyczy), Publisher: Taylor Francis Online
    Status:
    Published
    DOI:
    10.1080/2159256X.2016.1154637 – link to the publication

  2. The matrix domain contributes to the nucleic acid chaperone activity of HIV-2 Gag

    Authors:
    Katarzyna Pachulska-Wieczorek, Leszek Błaszczyk, Marcin Biesiada, Ryszard W. Adamiak and Katarzyna J. Purzycka
    Academic press:
    Retrovirology (year: 2016, volume: 0,554166666666667, pages: 46037), Publisher: Springer Bio Med Central
    Status:
    Published
    DOI:
    10.1186/s12977-016-0245-1 – link to the publication

  3. Ty1 retrovirus-like element Gag contains overlapping restriction factor and nucleic acid chaperone functions

    Authors:
    Nishida Y, Pachulska-Wieczorek K, Błaszczyk L, Saha A, Gumna J, Garfinkel DJ, Purzycka KJ
    Academic press:
    Nucleic Acids Research (year: 2015, volume: nie dotyczy, pages: nie dotyczy), Publisher: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gkv695 – link to the publication

  4. Complex RNA Post-transcriptional Element of a Simple Retrovirus

    Authors:
    Katarzyna J. Purzycka1, Guy R. Pilkington, Barbara K. Felber and Stuart F.J. Le Grice
    Academic press:
    Mobile Genetic Elements (year: 2015, volume: 5, pages: 46026), Publisher: Bioscience; Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/2159256X.2015.1017085 – link to the publication

  5. Similarities and differences in the nucleic acid chaperone activity of HIV-2 and HIV-1 nucleocapsid proteins in vitro

    Authors:
    K. Pachulska-Wieczorek, A.K. Stefaniak, K.J. Purzycka
    Academic press:
    Retrovirology (year: 2014, volume: 0,495833333333333, pages: 46035), Publisher: Springer Bio Med Central
    Status:
    Published
    DOI:
    10.1186/1742-4690-11-54 – link to the publication

  6. Determinants of Genomic RNA Encapsidation in the Saccharomyces cerevisiae Long Terminal Repeat Retrotransposons Ty1 and Ty3

    Authors:
    Pachulska-Wieczorek K, Le Grice SF, Purzycka KJ.
    Academic press:
    Viruses (year: 2016, volume: 8, pages: 46038), Publisher: MPDI
    Status:
    Published
    DOI:
    10.3390/v8070193 – link to the publication

  7. A self-encoded capsid derivative restricts Ty1 retrotransposition in Saccharomyces

    Authors:
    Garfinkel DJ, Tucker JM, Saha A, Nishida Y, Pachulska-Wieczorek K, Błaszczyk L, Purzycka KJ.
    Academic press:
    Current Genetics (year: 2015, volume: 62, pages: 321-329), Publisher: Springer Link
    Status:
    Published
    DOI:
    10.1007/s00294-015-0550-6 – link to the publication

Articles in post-conference publications (3)

  1. Insight into thebiological functions of retroelement's RNA through the predictions and analyses of their RNA 3D structures

    Authors:
    Marcin Biesiada, Katarzyna Pachulska-Wieczorek, Leszek Blaszczyk, Julita Gumna, Ryszard W. Adamiak, Katarzyna J. Purzycka
    Conference:
    The 20th Annual Meeting of the RNA Society, Madison, Wisconsin USA (year: 2015, pages: 222), Publisher: RNA Society
    Date:
    conference 26 - 31.05
    Status:
    Published
    DOI:
    link to the publication

  2. Nucleic acid chaperone activity of retroviral proteins

    Authors:
    Pachulska-Wieczorek K., Stefaniak A.K., Purzycka K.J., L. Błaszczyk, M. Biesiada and Adamiak R.W
    Conference:
    BIO 2014 (year: 2014, pages: 172), Publisher: Acta Biochimica Polonica
    Date:
    conference 9 - 12.09.2015 Warszawa
    Status:
    Published
    DOI:
    link to the publication

  3. Strukturalne i funkcjonalne aspekty oddziaływania poliproteiny Gag z RNA u retrowirusó w

    Authors:
    Pachulska-Wieczorek K., Purzycka K.J., Biesiada M., Błaszczyk L.,Adamiak R.W.
    Conference:
    58 Zjazd Naukowy PTChem (year: 2015, pages: 433), Publisher: PTChem
    Date:
    conference 21-25.09
    Status:
    Published
    DOI:
    link to the publication

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