Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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RNA chaperone activity of HIV-2 Gag and nuclocapsid proteins: implications for the design of the new retroviral inhibitors

2011/01/D/NZ1/03478

Keywords:

HIV genomic RNA dimerization nucleic acids chaperones Gag NC MA retroviral inhibitors

Descriptors:

  • NZ1_1: Molecular biology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Chemii Bioorganicznej PAN

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Katarzyna Pachulska-Wieczorek 

Number of co-investigators in the project: 4

Call: SONATA 1 - announced on 2011-03-15

Amount awarded: 390 000 PLN

Project start date (Y-m-d): 2011-12-07

Project end date (Y-m-d): 2015-06-06

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Aparat do sekwencyjnej elektroforezy pionowej (10 000 PLN)
  2. Inkubator z wytrząsaniem do prowadzenia hodowli bakteryjnych (35 000 PLN)
  3. Lampa UV 254/365nm (3 000 PLN)
  4. szafa chłodnicza.
  5. Aparat do elektroforezy poziomej w żelu agarozowym (1 000 PLN)
  6. komputer z oprogramowaniem.
  7. pompa olejowa (11 000 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  • Articles in post-conference publications (3)
  1. Ty1 retrovirus-like element Gag contains overlapping restriction factor and nucleic acid chaperone functions
    Authors:
    Nishida Y, Pachulska-Wieczorek K, Błaszczyk L, Saha A, Gumna J, Garfinkel DJ, Purzycka KJ
    Academic press:
    Nucleic Acids Research (rok: 2015, tom: nie dotyczy, strony: nie dotyczy), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gkv695 - link to the publication
  2. A self-encoded capsid derivative restricts Ty1 retrotransposition in Saccharomyces
    Authors:
    Garfinkel DJ, Tucker JM, Saha A, Nishida Y, Pachulska-Wieczorek K, Błaszczyk L, Purzycka KJ.
    Academic press:
    Current Genetics (rok: 2015, tom: 62, strony: 321-329), Wydawca: Springer Link
    Status:
    Published
    DOI:
    10.1007/s00294-015-0550-6 - link to the publication
  3. Determinants of Genomic RNA Encapsidation in the Saccharomyces cerevisiae Long Terminal Repeat Retrotransposons Ty1 and Ty3
    Authors:
    Pachulska-Wieczorek K, Le Grice SF, Purzycka KJ.
    Academic press:
    Viruses (rok: 2016, tom: 8, strony: 45307), Wydawca: MPDI
    Status:
    Published
    DOI:
    10.3390/v8070193 - link to the publication
  4. The matrix domain contributes to the nucleic acid chaperone activity of HIV-2 Gag
    Authors:
    Katarzyna Pachulska-Wieczorek, Leszek Błaszczyk, Marcin Biesiada, Ryszard W. Adamiak and Katarzyna J. Purzycka
    Academic press:
    Retrovirology (rok: 2016, tom: 0,554166666666667, strony: 45306), Wydawca: Springer Bio Med Central
    Status:
    Published
    DOI:
    10.1186/s12977-016-0245-1 - link to the publication
  5. Complex RNA Post-transcriptional Element of a Simple Retrovirus
    Authors:
    Katarzyna J. Purzycka1, Guy R. Pilkington, Barbara K. Felber and Stuart F.J. Le Grice
    Academic press:
    Mobile Genetic Elements (rok: 2015, tom: 5, strony: 45295), Wydawca: Bioscience; Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/2159256X.2015.1017085 - link to the publication
  6. Similarities and differences in the nucleic acid chaperone activity of HIV-2 and HIV-1 nucleocapsid proteins in vitro
    Authors:
    K. Pachulska-Wieczorek, A.K. Stefaniak, K.J. Purzycka
    Academic press:
    Retrovirology (rok: 2014, tom: 0,495833333333333, strony: 45304), Wydawca: Springer Bio Med Central
    Status:
    Published
    DOI:
    10.1186/1742-4690-11-54 - link to the publication
  7. Characterizing the functions of Ty1 Gag and the Gag-derived restriction factor p22/p18
    Authors:
    Pachulska-Wieczorek K, Błaszczyk L, Gumna J, Nishida Y, Saha A, Biesiada M, Garfinkel DJ, Purzycka KJ
    Academic press:
    Mobile Genetic Elements (rok: 2016, tom: 6, strony: nie dotyczy), Wydawca: Taylor Francis Online
    Status:
    Published
    DOI:
    10.1080/2159256X.2016.1154637 - link to the publication
  1. Insight into thebiological functions of retroelement's RNA through the predictions and analyses of their RNA 3D structures
    Authors:
    Marcin Biesiada, Katarzyna Pachulska-Wieczorek, Leszek Blaszczyk, Julita Gumna, Ryszard W. Adamiak, Katarzyna J. Purzycka
    Conference:
    The 20th Annual Meeting of the RNA Society, Madison, Wisconsin USA (rok: 2015, ), Wydawca: RNA Society
    Data:
    konferencja 26 - 31.05
    Status:
    Published
    DOI:
    link to the publication
  2. Nucleic acid chaperone activity of retroviral proteins
    Authors:
    Pachulska-Wieczorek K., Stefaniak A.K., Purzycka K.J., L. Błaszczyk, M. Biesiada and Adamiak R.W
    Conference:
    BIO 2014 (rok: 2014, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 9 - 12.09.2015 Warszawa
    Status:
    Published
    DOI:
    link to the publication
  3. Strukturalne i funkcjonalne aspekty oddziaływania poliproteiny Gag z RNA u retrowirusó w
    Authors:
    Pachulska-Wieczorek K., Purzycka K.J., Biesiada M., Błaszczyk L.,Adamiak R.W.
    Conference:
    58 Zjazd Naukowy PTChem (rok: 2015, ), Wydawca: PTChem
    Data:
    konferencja 21-25.09
    Status:
    Published
    DOI:
    link to the publication

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