Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The search for novel human proteasome inhibitors and fluorogenic substrates.

2011/01/D/ST5/02778

Keywords:

human proteasome fluorogenic substrates inhibitors

Descriptors:

  • ST5_16:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet Gdański, Wydział Chemii

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Dawid Dębowski 

Number of co-investigators in the project: 5

Call: SONATA 1 - announced on 2011-03-15

Amount awarded: 437 500 PLN

Project start date (Y-m-d): 2011-12-13

Project end date (Y-m-d): 2015-12-12

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Initiator+ SPWave półautomatyczny, mikrofalowy syntezator peptydów (145 000 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (4)
  1. Novel internally quenched substrate of the trypsin-like subunit of 20S eukaryotic proteasome
    Authors:
    Natalia Gruba, Magdalena Wysocka, Magdalena Brzezińska, Dawid Dębowski, Krzysztof Rolka, Nathaniel Martin, Adam Lesner
    Academic press:
    Analytical Biochemistry (rok: 2015, tom: -, strony: 45299), Wydawca: Elsevier
    Status:
    Accepted for publication
    DOI:
    10.1016/j.ab.2015.08.019 - link to the publication
  2. Bladder cancer detection using new substrate of 20S proteasome.
    Authors:
    N. Gruba, M. Wysocka, M. Brzezińska, M. Sieńczyk, D. Dębowski, K. Rolka, C. Czaplewski, E. Gorodkiewicz, T. Guszcz, A. Lesner
    Academic press:
    FEBS Journal (rok: 2015, tom: -, strony: -), Wydawca: Wiley Online Library
    Status:
    Submitted
    DOI:
    brak - link to the publication
  3. Interactions between trypsin and its peptidic inhibitors studied by isothermal titration calorimetry (ITC)
    Authors:
    Dawid Dębowski,Dariusz Wyrzykowski,Marta Lubos, Krzysztof Rolka
    Academic press:
    Journal of Thermal Analysis and Calorimetry (rok: 2015, tom: 123, strony: 807-812), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s10973-015-4993-2 - link to the publication
  4. Non-covalent inhibitors of human 20S and 26S proteasome based on trypsin inhibitor SFTI-1
    Authors:
    Dawid Dębowski, Mirosława Cichorek, Marta Lubos, Sławomir Wójcik, Anna Łęgowska, Krzysztof Rolka
    Academic press:
    Peptide Science (rok: 2015, tom: -, strony: -), Wydawca: Wiley Online Library
    Status:
    Submitted
    DOI:
    brak - link to the publication
  5. Natural Proteinaceous Inhibitors of Serine Proteases
    Authors:
    Dawid Dębowski
    Academic press:
    Current Pharmaceutical Design (rok: 2013, tom: 19, strony: 1068-84), Wydawca: Bentham Science Publishers
    Status:
    Published
    DOI:
    link to the publication
  6. Inhibition of Human and Yeast 20S Proteasome by Analogues of Trypsin Inhibitor SFTI-1.
    Authors:
    Dawid Dębowski, Michał Pikuła, Marta Lubos, Paulina Langa, Piotr Trzonkowski, Adam Lesner, Anna Łęgowska, Krzysztof Rolka
    Academic press:
    PLoS One (rok: 2014, tom: 9, strony: e89465), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0089465 - link to the publication
  1. Analogues of SFTI-1 as the potential inhibitors of the 20S proteasome
    Authors:
    Dawid Dębowski, Aneta Mizeria, Adam Lesner, Anna Łęgowska, Krzysztof Rolka
    Conference:
    32nd European Peptide Symposium, Athens 2012 (rok: 2012, ), Wydawca: The European Peptide Society, Proceedings of 32nd European Peptide Symposium edited by G. Kokotos, V. Constantinou-Kokotous, J. Matsoukas
    Data:
    konferencja 2-7 September 2012
    Status:
    Published
  2. Characteristics of caspase-like specificity of human 20S proteasome using combinatorial chemistry methods
    Authors:
    Natalia Gruba, Magda Wysocka, Adam Lesner, Dawid Dębowski, Krzysztof Rolka
    Conference:
    33rd European Peptide Symposium, Sofia 2014 (rok: 2014, ), Wydawca: European Peptide Society, Proceedings of 33rd European Peptide Symposium edited by E. Naydenova, T. Pajpanova, D. Danalev
    Data:
    konferencja 31 August – 5 September 2014
    Status:
    Published
  3. New internally quenched substrates of human 20S proteasome.
    Authors:
    Natalia Gruba, Magdalena Wysocka, Dawid Dębowski, Ewa Gorodkiewicz, Adam Lesner, Krzysztof Rolka.
    Conference:
    33rd European Peptide Symposium, Sofia 2014 (rok: 2014, ), Wydawca: European Peptide Society, Proceedings of 33rd European Peptide Symposiumedited by E. Naydenova, T. Pajpanova, D. Danalev
    Data:
    konferencja 31 August – 5 September 2014
    Status:
    Published
  4. Non-covalent peptidic inhibitors of human 20S proteasome
    Authors:
    Dawid Dębowski, Natalia Karna, Agata Gitlin, Marta Lubos, Anna Łęgowska, Krzysztof Rolka
    Conference:
    33rd European Peptide Symposium, Sofia 2014 (rok: 2014, ), Wydawca: European Peptide Society, Proceedings of 33rd European Peptide Symposium edited by E. Naydenova, T. Pajpanova, D. Danalev
    Data:
    konferencja 31 August – 5 September 2014
    Status:
    Published

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