Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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New chemical and biological properties of topoizomeraze I inhibitors alkylating DNA oligomers

2012/07/B/ST4/00566

Keywords:

Photochemical properies biological properties DNA oligomers topo I inhibitors DNA alkylation NMR MS

Descriptors:

  • ST4_3: Molecular architecture and structure
  • ST5_23:
  • NZ1_4: Structural biology

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Instytut Chemii Organicznej PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Lech Kozerski 

Number of co-investigators in the project: 7

Call: OPUS 4 - announced on 2012-09-15

Amount awarded: 778 240 PLN

Project start date (Y-m-d): 2013-07-10

Project end date (Y-m-d): 2017-04-09

Project duration:: 45 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Degaser do odgazowywania faz ciekłych w HPLC z gradientem (10 000 PLN)
  2. Detektor UV VIS DAD (50 000 PLN)
  3. Zestaw laboratoryjny do prowadzenia reakcji w UV w obniżonych temperaturach. (10 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  1. New generation of camptothecin derivatives spontaneously alkylating DNA
    Authors:
    Beata Naumczuk, Katarzyna Wiktorska, Katarzyna Lubelska, Robert Kawęcki, Wojciech Bocian, Elżbieta Bednarek, Jerzy Sitkowski, Zdzisław Chilmończyk, and Lech Kozerski
    Academic press:
    New Journal of Chemistry (rok: 2016, tom: 40, strony: 7978-7985), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c6n/01217/e - link to the publication
  2. Preliminary study of mechanism of action ofSN38 derivatives. Physicochemical data,evidence of interaction and alkylation of DNA octamer d(GCGATCGC)2
    Authors:
    Beata Naumczuk,a* Beata Naumczuk, Robert Kawęcki, Wojciech Bocian, Elżbieta Bednarek,Jerzy Sitkowski and Lech Kozerskia
    Academic press:
    Magnetic Resonance in Chemistry (rok: 2017, tom: 55, strony: 128-136), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1002/mrc.4508 - link to the publication
  3. DOSY and MALDI-TOF evidence of covalent biding the DNA duplex by trimethylammonium salts of topootecan upon near UV irradiation
    Authors:
    Beata Naumczuk, Robert Kawęcki, Wojciech Bocian, Elżbieta Bednarek, Jerzy Sitkowski, Ewelina Wielgus, Lech Kozerski
    Academic press:
    Magnetic Resonance in Chemistry (rok: 2015, tom: 53, strony: 565-571), Wydawca: John Wiley & Sons, Ltd.
    Status:
    Published
    DOI:
    10.1002/mrc.4255 - link to the publication
  4. Spontaneous 2'-deoxyguanosine alkylation by a new generation of topoisomerase I inhibitors of the camptothecin family
    Authors:
    B. Naumczuk, R. Kawęcki, J. Sitkowski,W. Bocian, E. Bednarek and |L. Kozerski
    Academic press:
    New Journal of Chemistry (rok: 2016, tom: 40, strony: 3010-3013), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c5nj03497c - link to the publication

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