Projects funded by the NCN

Synthesis and study of anticancer activities and affinities to kinesin of selected sandwich and half-sandwich organometa...

Call: OPUS 9 , Panel: ST5

Principal investigator: dr hab. Damian Nestor Plażuk

Uniwersytet Łódzki, Wydział Chemii

Analysis of selected physicochemical, biological and pharmacological properties of biomedical materials modified by synt...

Call: PRELUDIUM 8 , Panel: NZ7

Principal investigator: dr Katarzyna Szałapata

Uniwersytet Marii Curie-Skłodowskiej w Lublinie, Wydział Biologii i Biotechnologii

Synthesis of fluorogenic substrates, inhibitors and activity-based probes of human neutrophil proteinase NSP4 and its ev...

Call: OPUS 8 , Panel: ST5

Principal investigator: prof. Adam Jerzy Lesner

Uniwersytet Gdański, Wydział Chemii

Study of casein kinase CK2 inhibition mechanisms

Call: OPUS 1 , Panel: ST5

Principal investigator: prof. Maria Wanda Bretner

Politechnika Warszawska, Wydział Chemiczny

Design and synthesis of probes for RabGGTase profiling and their application for identification of the site of phosphono...

Call: SONATA BIS 4 , Panel: ST5

Principal investigator: dr hab. Katarzyna Błażewska

Politechnika Łódzka, Wydział Chemiczny

Chemical syntesis and evaluation of biochemical properties of 7-methyloguanosine 5'-diphosphate analogs as inhibitors of...

Call: PRELUDIUM 1 , Panel: NZ1

Principal investigator: Marcin Jarosław Ziemniak

Uniwersytet Warszawski, Wydział Fizyki

Design and synthesis of phosphoroorganic antagonists of BIR domain of apoptosis inhibitor proteins (IAP)

Call: PRELUDIUM 7 , Panel: ST5

Principal investigator: dr Agnieszka Łupicka-Słowik

Politechnika Wrocławska, Wydział Chemiczny

The study of synergistic inhibition of tumor cell proliferation by CK2 casein kinase inhibitors and inhibitors of thymid...

Call: OPUS 7 , Panel: NZ7

Principal investigator: prof. Maria Wanda Bretner

Politechnika Warszawska, Wydział Chemiczny

Novel polyelectrolytes as potential inhibitors of HSV-1 virus - synthesis, properties and mechanism of action

Call: OPUS 7 , Panel: ST5

Principal investigator: prof. Maria Nowakowska

Uniwersytet Jagielloński, Wydział Chemii

Novel type modulators of purinergic receptors - Synthesis and study of receptor-ligand interaction

Call: OPUS 7 , Panel: NZ1

Principal investigator: prof. Zbigniew Jan Leśnikowski

Instytut Biologii Medycznej Polskiej Akademii Nauk

Design, chemical synthesis and biological activity of inhibitors of matriptase-2.

Call: PRELUDIUM 7 , Panel: ST5

Principal investigator: Agata Elżbieta Gitlin-Domagalska

Uniwersytet Gdański, Wydział Chemii

Poszukiwanie inhibitorów oddziaływania białek MDM2-p53. Trójpodstawione pochodne 1,5-dihydro-2H-pirol-2-onu.

Call: ETIUDA 2 , Panel: ST5

Principal investigator: Ewa Maria Wrona

Uniwersytet Jagielloński, Wydział Chemii

Structure optimization of inhibitor for paracaspase MALT1

Call: PRELUDIUM 6 , Panel: ST5

Principal investigator: dr Paulina Maria Kasperkiewicz

Politechnika Wrocławska, Wydział Chemiczny

Endogenous enkephalinase inhibitors and their novel synthetic analogs as potential new therapeutics for the treatment of...

Call: OPUS 6 , Panel: NZ7

Principal investigator: dr hab. Jakub Jerzy Fichna

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Bioactive organoselenium compounds in self-organizing systems: design, synthesis and biological evaluation

Call: SONATA 5 , Panel: ST5

Principal investigator: dr Magdalena Piętka-Ottlik

Politechnika Wrocławska, Wydział Chemiczny

Studies on the metal ions impact on the structure and functions of peptidic inhibitors of aggregation of proteins involv...

Call: OPUS 1 , Panel: ST5

Principal investigator: dr Marek Józef Łuczkowski

Uniwersytet Wrocławski, Wydział Chemii

The search for novel human proteasome inhibitors and fluorogenic substrates.

Call: SONATA 1 , Panel: ST5

Principal investigator: dr Dawid Dębowski

Uniwersytet Gdański, Wydział Chemii

Design and synthesis of acylpeptide hydrolase inhibitors as potential inducers of apoptosis in tumor cells

Call: PRELUDIUM 5 , Panel: ST5

Principal investigator: Maciej Sławomir Walczak

Politechnika Wrocławska, Wydział Chemiczny

Design and synthesis of selective and irreversible inhibitors of HAT protease.

Call: PRELUDIUM 5 , Panel: ST5

Principal investigator: Marcin Skoreński

Politechnika Wrocławska, Wydział Chemiczny

New methods for mRNA 5' end labeling and examples of their application in studies on RNA metabolism and searching for in...

Call: OPUS 5 , Panel: ST5

Principal investigator: dr hab. Jacek Jemielity

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Morita-Baylis-Hillman adducts as substrates in the synthesis of biologically active organophosphorus compounds

Call: OPUS 5 , Panel: ST5

Principal investigator: dr hab. Artur Jacek Mucha

Politechnika Wrocławska, Wydział Chemiczny

Synthesis and studies of reaction products of oxirane derivatives with the -NH-(C=)-Br functionality of heteroaromatic c...

Call: PRELUDIUM 1 , Panel: NZ4

Principal investigator: dr Marzena Agnieszka Baran

Uniwersytet Jagielloński- Collegium Medicum, Wydział Farmaceutyczny z Oddziałem Analityki Medycznej

Designing mRNA transcripts resistant to enzymatic cap hydrolysis applicable for anti-cancer vaccines; multiplexed bioche...

Call: MAESTRO 4 , Panel: NZ1

Principal investigator: prof. Edward Darżynkiewicz

Uniwersytet Warszawski

Design, chemical synthesis and enzymatic evaluation of peptidic substrates and inhibitors of cathepsin C

Call: PRELUDIUM 4 , Panel: ST5

Principal investigator: dr Monika Katarzyna Łęgowska

Uniwersytet Gdański, Wydział Chemii

Synthesis and preliminary studies on biological activity of glycosyltransferases natural substrates analogues, derivativ...

Call: PRELUDIUM 4 , Panel: ST5

Principal investigator: Roman Marcin Komor

Politechnika Śląska, Wydział Chemiczny

One-pot synthesis of O-2-isocepham and N-2-isocepham derivatives bearing retroamide/thioretroamide or phosphono/thiophos...

Call: PRELUDIUM 4 , Panel: NZ7

Principal investigator: Marta Leokadia Schielmann

Politechnika Gdańska, Wydział Chemiczny

Synthesis and pharmacological properties of mono- di- and triheterocyclic azole derivatives as a hybrid receptor and PDE...

Call: OPUS 4 , Panel: NZ7

Principal investigator: prof. Maciej Henryk Pawłowski

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

DNA double-stranded break repair proteins as a target for personalized cancer therapy based on synthetic lethality

Call: OPUS 4 , Panel: NZ7

Principal investigator: dr hab. Tomasz Śliwiński

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Synthesis and analysis of potential furin inhibitors in the development of the new therapeutic strategies against viral ...

Call: PRELUDIUM 4 , Panel: ST5

Principal investigator: Monika Aleksandra Lewandowska-Goch

Uniwersytet Gdański, Wydział Chemii

Structure - activity relationship studies of new flavonoids derivatives as the inhibitors of the bacterial tyrosyl-tRNA ...

Call: PRELUDIUM 3 , Panel: NZ7

Principal investigator: dr Mirosława Anna Skupińska

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Diaminophosphonates as specific inhibitors of Neisseria meningitidis aminopeptidase N - synthesis and biological activit...

Call: PRELUDIUM 3 , Panel: ST5

Principal investigator: Ewelina Marta Węglarz-Tomczak

Politechnika Wrocławska, Wydział Chemiczny

Organometallic inhibitors of tubulin polymerisation. Synthesis, anticancer activities and tubulin affinities.

Call: OPUS 3 , Panel: ST5

Principal investigator: dr hab. Damian Plażuk

Uniwersytet Łódzki, Wydział Chemii

Modifications of aglycones of leucomycins via Michael addition and Huisgen dipolar cycloaddition as a new routes of synt...

Call: SONATA BIS 1 , Panel: ST5

Principal investigator: dr hab. Piotr Przybylski

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

Identification of amino acid residues located in positions P7 and P8 of model inhibitor of proprotein convertases that d...

Call: PRELUDIUM 3 , Panel: ST5

Principal investigator: Izabela Małuch

Uniwersytet Gdański, Wydział Chemii

Synthesis of mononucleotide N2,N2,7-trimethylguanosine cap analogues as translation inhibitors in Ascaris suum

Call: PRELUDIUM 3 , Panel: ST5

Principal investigator: dr Karolina Ewa Piecyk

Uniwersytet Warszawski, Wydział Chemii

Conjugates of cap analogs with nanomaterials and biomolecules with potential applications in pharmacology or diagnostics

Call: SONATA 1 , Panel: ST5

Principal investigator: dr Joanna Kowalska

Uniwersytet Warszawski, Wydział Fizyki

Role of ruthenium complexes interaction with NO in the context of angiogenesis inhibition.

Call: PRELUDIUM 3 , Panel: ST5

Principal investigator: dr Maria Józefa Oszajca

Uniwersytet Jagielloński, Wydział Chemii

Peptide splicing - the mechanism and its application for designing compounds with potential use in medicinal practice

Call: OPUS 1 , Panel: ST5

Principal investigator: prof. Krzysztof Rolka

Uniwersytet Gdański, Wydział Chemii

New approaches towards modulating selective and functional activities of antisense oligonucleotides

Call: OPUS 2 , Panel: ST5

Principal investigator: prof. Ryszard Kierzek

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Novel insights into inhibition of PD-L1/PD-1 immune checkpoint – discovery and optimization of covalent PD-L1 inhibitors...

Call: SONATA 20 , Panel: ST5

Principal investigator: dr Radosław Dariusz Kitel

Uniwersytet Jagielloński

Frog skin derived cyclic peptide as a molecular scaffold to create a novel tool for combining visualization and inhibiti...

Call: PRELUDIUM 23 , Panel: ST5

Principal investigator: Aleksandra Dorota Helbik-Maciejewska

Uniwersytet Gdański

Development and characterization of novel multitargeted organometallic tubulin polymerization inhibitors for enhancing t...

Call: OPUS 27 , Panel: NZ7

Principal investigator: dr hab. Damian Nestor Plażuk

Uniwersytet Łódzki

Design, synthesis and biological evaluation of Steroid Sulfatase Inhibitors based on organophosphorus compounds.

Call: SONATA 2 , Panel: NZ7

Principal investigator: dr Sebastian Demkowicz

Politechnika Gdańska

Design and synthesis of new rifampicin analogs as a source of effective bacterial RNA polymerase inhibitors

Call: OPUS 2 , Panel: ST5

Principal investigator: dr hab. Piotr Przybylski

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

Theoretical prediction, chemical synthesis and biological analysis of a novel class of HSPA5 inhibitors

Call: OPUS 25 , Panel: ST4

Principal investigator: prof. Arkadiusz Chworoś

Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

Synthesis and biological activity evaluation of new hybrid derivatives of tacrine and melatonin as potential cholinester...

Call: OPUS 2 , Panel: ST5

Principal investigator: dr Anna Zawadzka

Uniwersytet Warszawski, Wydział Chemii

The design and development of the peptide inhibitors library targeting Zn(II)-binding site of matrix metalloproteinases ...

Call: PRELUDIUM 22 , Panel: ST5

Principal investigator: Paulina Alicja Potok

Uniwersytet Wrocławski, Wydział Chemii

Feel the chemistry if you're close enough - proximity-induced SuFEx ligation for mRNA biology and medicine

Call: OPUS 25 , Panel: ST5

Principal investigator: prof. Jacek Jemielity

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Design, synthesis and in vitro and in vivo studies of anticancer potential of phosphonic and phosphinic analogs of sulfo...

Call: OPUS 2 , Panel: ST5

Principal investigator: prof. Tadeusz Marek Gajda

Politechnika Łódzka, Wydział Chemiczny

Structure-guided design of histone demethylase inhibitors for cancer therapy.

Call: SONATA 17 , Panel: NZ7

Principal investigator: dr Piotr Henryk Małecki

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk