Projects funded by the NCN

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44 projects found matching your search criteria :

  1. Development and study of peptide inhibitors of membrane fusion in flaviviruses, based on the STEM region of the tick-bor...

    Call: PRELUDIUM 24 , Panel: NZ6

    Principal investigator: Krzysztof Polaczek

    Uniwersytet Gdański

  2. Tick-borne encephalitis virus protease as a molecular target for novel inhibitors and activity-based probes

    Call: OPUS 28 , Panel: NZ6

    Principal investigator: dr Renata Grzywa

    Politechnika Wrocławska

  3. Development and characterization of novel multitargeted organometallic tubulin polymerization inhibitors for enhancing t...

    Call: OPUS 27 , Panel: NZ7

    Principal investigator: dr hab. Damian Nestor Plażuk

    Uniwersytet Łódzki

  4. Theoretical prediction, chemical synthesis and biological analysis of a novel class of HSPA5 inhibitors

    Call: OPUS 25 , Panel: ST4

    Principal investigator: prof. Arkadiusz Chworoś

    Centrum Badań Molekularnych i Makromolekularnych PAN

  5. Structure-guided design of histone demethylase inhibitors for cancer therapy.

    Call: SONATA 17 , Panel: NZ7

    Principal investigator: dr Piotr Henryk Małecki

    Instytut Chemii Bioorganicznej PAN

  6. Blocking the TNF-TNFR2 interactions as a novel approach to the ovarian carcinoma treatment

    Call: OPUS 21 , Panel: NZ7

    Principal investigator: prof. Sylwia Anna Rodziewicz-Motowidło

    Uniwersytet Gdański, Wydział Chemii

  7. The SAR analysis and synthesis of complex, small molecule PD-1/PD-L1 interaction antagonists

    Call: PRELUDIUM 20 , Panel: ST4

    Principal investigator: Magdalena Maria Żarnik

    Uniwersytet Jagielloński, Wydział Chemii

  8. Synthesis and evaluation of PD-L1 inhibitors based on mixed mode scaffolds containing amino acid derivatives, short pept...

    Call: SONATA 16 , Panel: ST4

    Principal investigator: dr Ewa Maria Surmiak

    Uniwersytet Jagielloński, Wydział Chemii

  9. Structure optimization of the PD-1/PD-L1 inhibitors based on the terphenyl scaffold

    Call: PRELUDIUM 19 , Panel: ST4

    Principal investigator: dr Damian Muszak

    Uniwersytet Jagielloński, Wydział Chemii

  10. CP protease of the O'nyong-nyong virus: substrate profiling, design and synthesis of inhibitors and activity-based probe...

    Call: OPUS 15 , Panel: NZ6

    Principal investigator: dr hab. Marcin Sieńczyk

    Politechnika Wrocławska

  11. Aminophosphonates bearing fluorine atoms as inhibitors odf aminopeptideses and their potential application for determina...

    Call: HARMONIA 9 , Panel: ST5

    Principal investigator: prof. Paweł Kazimierz Kafarski

    Politechnika Wrocławska

  12. Synthesis of 2-phosphonocarboxylates as potential covalent inhibitors of Rab geranylgeranyl transferase

    Call: PRELUDIUM 12 , Panel: ST5

    Principal investigator: Joanna Natalia Małolepsza

    Politechnika Łódzka, Wydział Chemiczny

  13. Novel multi-target directed ligands combining cholinesterase inhibition and 5-HT6 antagonism - design, synthesis and pha...

    Call: SONATA 12 , Panel: NZ7

    Principal investigator: dr hab. Anna Karolina Więckowska

    Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

  14. Anticancer activity of novel tubulin polymerization inhibitors obtained by the chemical modification of colchicine

    Call: OPUS 11 , Panel: ST5

    Principal investigator: dr hab. Adam Włodzimierz Huczyński

    Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

  15. Design, synthesis and biological evaluation of the new steroid sulfatase (STS) inhibitors based on sulfamate analogs con...

    Call: PRELUDIUM 10 , Panel: NZ7

    Principal investigator: Mateusz Daśko

    Politechnika Gdańska, Wydział Chemiczny

  16. Synthesis of new glutamate receptors antagonists and extensive investigation of their effect on tumor cells in the prese...

    Call: OPUS 9 , Panel: ST5

    Principal investigator: prof. Maria Wanda Bretner

    Politechnika Warszawska, Wydział Chemiczny

  17. Synthesis and study of anticancer activities and affinities to kinesin of selected sandwich and half-sandwich organometa...

    Call: OPUS 9 , Panel: ST5

    Principal investigator: dr hab. Damian Nestor Plażuk

    Uniwersytet Łódzki, Wydział Chemii

  18. Synthesis of fluorogenic substrates, inhibitors and activity-based probes of human neutrophil proteinase NSP4 and its ev...

    Call: OPUS 8 , Panel: ST5

    Principal investigator: prof. Adam Jerzy Lesner

    Uniwersytet Gdański, Wydział Chemii

  19. Design and synthesis of probes for RabGGTase profiling and their application for identification of the site of phosphono...

    Call: SONATA BIS 4 , Panel: ST5

    Principal investigator: dr hab. Katarzyna Błażewska

    Politechnika Łódzka, Wydział Chemiczny

  20. Design and synthesis of phosphoroorganic antagonists of BIR domain of apoptosis inhibitor proteins (IAP)

    Call: PRELUDIUM 7 , Panel: ST5

    Principal investigator: dr Agnieszka Łupicka-Słowik

    Politechnika Wrocławska, Wydział Chemiczny

  21. Novel polyelectrolytes as potential inhibitors of HSV-1 virus - synthesis, properties and mechanism of action

    Call: OPUS 7 , Panel: ST5

    Principal investigator: prof. Maria Nowakowska

    Uniwersytet Jagielloński, Wydział Chemii

  22. Novel type modulators of purinergic receptors - Synthesis and study of receptor-ligand interaction

    Call: OPUS 7 , Panel: NZ1

    Principal investigator: prof. Zbigniew Jan Leśnikowski

    Instytut Biologii Medycznej PAN

  23. Design, chemical synthesis and biological activity of inhibitors of matriptase-2.

    Call: PRELUDIUM 7 , Panel: ST5

    Principal investigator: Agata Elżbieta Gitlin-Domagalska

    Uniwersytet Gdański, Wydział Chemii

  24. Bioactive organoselenium compounds in self-organizing systems: design, synthesis and biological evaluation

    Call: SONATA 5 , Panel: ST5

    Principal investigator: dr Magdalena Piętka-Ottlik

    Politechnika Wrocławska, Wydział Chemiczny

  25. Design and synthesis of acylpeptide hydrolase inhibitors as potential inducers of apoptosis in tumor cells

    Call: PRELUDIUM 5 , Panel: ST5

    Principal investigator: Maciej Sławomir Walczak

    Politechnika Wrocławska, Wydział Chemiczny

  26. Design and synthesis of selective and irreversible inhibitors of HAT protease.

    Call: PRELUDIUM 5 , Panel: ST5

    Principal investigator: Marcin Skoreński

    Politechnika Wrocławska, Wydział Chemiczny

  27. New methods for mRNA 5' end labeling and examples of their application in studies on RNA metabolism and searching for in...

    Call: OPUS 5 , Panel: ST5

    Principal investigator: dr hab. Jacek Jemielity

    Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

  28. Morita-Baylis-Hillman adducts as substrates in the synthesis of biologically active organophosphorus compounds

    Call: OPUS 5 , Panel: ST5

    Principal investigator: dr hab. Artur Jacek Mucha

    Politechnika Wrocławska, Wydział Chemiczny

  29. Design, chemical synthesis and enzymatic evaluation of peptidic substrates and inhibitors of cathepsin C

    Call: PRELUDIUM 4 , Panel: ST5

    Principal investigator: dr Monika Katarzyna Łęgowska

    Uniwersytet Gdański, Wydział Chemii

  30. Synthesis and preliminary studies on biological activity of glycosyltransferases natural substrates analogues, derivativ...

    Call: PRELUDIUM 4 , Panel: ST5

    Principal investigator: Roman Marcin Komor

    Politechnika Śląska, Wydział Chemiczny

  31. One-pot synthesis of O-2-isocepham and N-2-isocepham derivatives bearing retroamide/thioretroamide or phosphono/thiophos...

    Call: PRELUDIUM 4 , Panel: NZ7

    Principal investigator: Marta Leokadia Schielmann

    Politechnika Gdańska, Wydział Chemiczny

  32. Synthesis and pharmacological properties of mono- di- and triheterocyclic azole derivatives as a hybrid receptor and PDE...

    Call: OPUS 4 , Panel: NZ7

    Principal investigator: prof. Maciej Henryk Pawłowski

    Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

  33. Synthesis and analysis of potential furin inhibitors in the development of the new therapeutic strategies against viral ...

    Call: PRELUDIUM 4 , Panel: ST5

    Principal investigator: Monika Aleksandra Lewandowska-Goch

    Uniwersytet Gdański, Wydział Chemii

  34. Diaminophosphonates as specific inhibitors of Neisseria meningitidis aminopeptidase N - synthesis and biological activit...

    Call: PRELUDIUM 3 , Panel: ST5

    Principal investigator: Ewelina Marta Węglarz-Tomczak

    Politechnika Wrocławska, Wydział Chemiczny

  35. Organometallic inhibitors of tubulin polymerisation. Synthesis, anticancer activities and tubulin affinities.

    Call: OPUS 3 , Panel: ST5

    Principal investigator: dr hab. Damian Plażuk

    Uniwersytet Łódzki, Wydział Chemii

  36. Modifications of aglycones of leucomycins via Michael addition and Huisgen dipolar cycloaddition as a new routes of synt...

    Call: SONATA BIS 1 , Panel: ST5

    Principal investigator: dr hab. Piotr Przybylski

    Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

  37. Identification of amino acid residues located in positions P7 and P8 of model inhibitor of proprotein convertases that d...

    Call: PRELUDIUM 3 , Panel: ST5

    Principal investigator: Izabela Małuch

    Uniwersytet Gdański, Wydział Chemii

  38. Synthesis of mononucleotide N2,N2,7-trimethylguanosine cap analogues as translation inhibitors in Ascaris suum

    Call: PRELUDIUM 3 , Panel: ST5

    Principal investigator: dr Karolina Ewa Piecyk

    Uniwersytet Warszawski, Wydział Chemii

  39. Design, synthesis and biological evaluation of Steroid Sulfatase Inhibitors based on organophosphorus compounds.

    Call: SONATA 2 , Panel: NZ7

    Principal investigator: dr Sebastian Demkowicz

    Politechnika Gdańska

  40. Design and synthesis of new rifampicin analogs as a source of effective bacterial RNA polymerase inhibitors

    Call: OPUS 2 , Panel: ST5

    Principal investigator: dr hab. Piotr Przybylski

    Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

  41. Synthesis and biological activity evaluation of new hybrid derivatives of tacrine and melatonin as potential cholinester...

    Call: OPUS 2 , Panel: ST5

    Principal investigator: dr Anna Zawadzka

    Uniwersytet Warszawski, Wydział Chemii

  42. Chemical syntesis and evaluation of biochemical properties of 7-methyloguanosine 5'-diphosphate analogs as inhibitors of...

    Call: PRELUDIUM 1 , Panel: NZ1

    Principal investigator: Marcin Jarosław Ziemniak

    Uniwersytet Warszawski, Wydział Fizyki

  43. Synthesis and studies of reaction products of oxirane derivatives with the -NH-(C=)-Br functionality of heteroaromatic c...

    Call: PRELUDIUM 1 , Panel: NZ4

    Principal investigator: dr Marzena Agnieszka Baran

    Uniwersytet Jagielloński- Collegium Medicum, Wydział Farmaceutyczny z Oddziałem Analityki Medycznej

  44. Peptide splicing - the mechanism and its application for designing compounds with potential use in medicinal practice

    Call: OPUS 1 , Panel: ST5

    Principal investigator: prof. Krzysztof Rolka

    Uniwersytet Gdański, Wydział Chemii

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