Projects funded by the NCN
Morita-Baylis-Hillman adducts as substrates in the synthesis of biologically active organophosphorus compounds
2013/09/B/ST5/00090
Keywords:
Morita-Baylis-Hillman reaction nucleophilic substitution phosphinic peptides polyphosphonates enzyme inhibitors
Descriptors:
- ST5_23:
- ST5_16:
Panel:
ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering
Host institution :
Politechnika Wrocławska, Wydział Chemiczny
woj. dolnośląskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 7
Call: OPUS 5 - announced on 2013-03-15
Amount awarded: 695 100 PLN
Project start date (Y-m-d): 2014-02-21
Project end date (Y-m-d): 2017-02-20
Project duration:: 36 months (the same as in the proposal)
Project status: Project settled
Equipment purchased [PL]
- Laptop.
- System preparatywnej chromatografii cieczowej (Flash) (210 000 PLN)
- Wyparka rotacyjna (15 000 PLN)
- Mieszadła magnetyczne (2 szt.) (6 000 PLN)
- Komputer z monitorem.
- Pompa próżniowa.
Information in the final report
- Publication in academic press/journals (3)
- Articles in post-conference publications (1)
- Structure-guided, Single-point Modifications in the Phosphinic Dipeptide Structure Yield Highly Potent and Selective Inhibitors of Neutral AminopeptidasesAuthors:Vassiliou, S.; Węglarz-Tomczak, E.; Berlicki, Ł.; Pawełczak, M.; Nocek, B.; Mulligan, R.; Joachimiak, A.; Mucha, A.Academic press:Journal of Medicinal Chemistry (rok: 2014, tom: 57, strony: 8140-8151), Wydawca: American Chemical SocietyStatus:PublishedDOI:10.1021/jm501071f - link to the publication
- P-C bond formation in reactions of Morita-Baylis-Hillman adducts with phosphorus nucleophilesAuthors:Talma, M.; Mucha, A.Academic press:Arkivoc (rok: 2017, tom: 2017, strony: 324-344), Wydawca: AkivocStatus:PublishedDOI:10.3998/ark.5550190.p009.787 - link to the publication
- Novel organophosphorus scaffolds of urease inhibitors obtained by substitution of Morita-Baylis-Hillman adducts with phosphorus nucleophilesAuthors:Ntatsopoulos, V.; Vassiliou, S.; Macegoniuk, K.; Berlicki, Ł.; Mucha, A.Academic press:European Journal of Medicinal Chemistry (rok: 2017, tom: 133, strony: 107-120), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.ejmech.2017.03.070 - link to the publication
- Substytucja octanów allilowych nukleofilami fosforowymi oraz zawierającymi atom fosforuAuthors:Maślanka, M.Conference:Ogólnopolska Konferencja Naukowa "Wiedza Kluczem do Sukcesu", Łódź (rok: 2017, ), Wydawca: Zeszyty Naukowe Towarzystwa Doktorantów Uniwersytetu Jagiellońskiego, Nauki ŚcisłeData:konferencja 21,01Status:Published