Projects funded by the NCN
The SAR analysis and synthesis of complex, small molecule PD-1/PD-L1 interaction antagonists
2021/41/N/ST4/03485
Keywords:
small molecule inhibitors immune checkpoint immunotherapy structure optimization SAR analysis organic synthesis cancer
Descriptors:
- ST4_008:
- ST4_009:
- ST4_003:
Panel:
ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development
Host institution :
Uniwersytet Jagielloński, Wydział Chemii
woj. małopolskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 2
Call: PRELUDIUM 20 - announced on 2021-03-15
Amount awarded: 139 710 PLN
Project start date (Y-m-d): 2022-02-03
Project end date (Y-m-d): 2024-02-02
Project duration:: 24 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (1)
- Exploring the Surface of the Ectodomain of the PD-L1 Immune Checkpoint with Small-Molecule FragmentsAuthors:Radoslaw Kitel, Ismael Rodríguez, Xabier del Corte, Jack Atmaj, Magdalena Żarnik, Ewa Surmiak, Damian Muszak, Katarzyna Magiera-Mularz, Grzegorz M. Popowicz, Tad A. Holak, and Bogdan Musielak*Academic press:ACS Chemical Biology (rok: 2022, tom: 17, strony: 2655-2663), Wydawca: American Chemical SocietyStatus:PublishedDOI:10.1021/acschembio.2c00583 - link to the publication