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Peptide splicing - the mechanism and its application for designing compounds with potential use in medicinal practice

2011/01/B/ST5/03772

Keywords

Descriptors

  • ST5_16: Chemia biologiczna
  • ST5_22: Chemia supramolekularna

Panel

ST5 – Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution

Uniwersytet Gdański, Wydział Chemii

Voivodeship: pomorskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Krzysztof Rolka

Number of co-investigators in the project: 8

Call

OPUS 1 – announced on 2011-03-15

Amount awarded
425 400 PLN
Project start date
2011-12-01
Project end date
2014-11-30
Project duration
36 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Mikroskop fluorescencyjny HBO 100, Carl Ceiss. Cost: 142 000 PLN

Information in the final report

Publication in academic press/journals (6)

  1. Investigation of peptide splicing using two-peptide-chain analogs of trypsin inhibitor SFTI-1

    Authors:
    Karna N., Dębowski D., Gitlin A., Łęgowska A., Rolka K.
    Academic press:
    FEBS J. (year: 2013, volume: 280, pages: 6213-6222), Publisher: Wiley Periodicals, Inc.
    Status:
    Published
    DOI:
    10.1111/febs.12542 – link to the publication

  2. Atomic resolution crystal structure ofHV-BBI protease inhibitor from amphibian skin in complex with bovine trypsin

    Authors:
    Grudnik P., Debowski D., Łegowska A., Malicki S., Golik P., Karna N., Rolka K., Dubin D.
    Academic press:
    Proteins (year: 2014, volume: -, pages: -), Publisher: Wiley Periodicals, Inc.
    Status:
    Published
    DOI:
    10.1002/prot.24750 – link to the publication

  3. Conformational studies of [Nphe5]SFTI-1 by means of 2D NMR spectroscopy in conjunction with molecular dynamics calculations

    Authors:
    Brzozowski K., Stawikowski M., Slusarz R., Sikorska E., Lesner A., Łęgowska A., Rolka K.
    Academic press:
    J.Mol. Struct. (year: 2015, volume: 1100, pages: 203-207), Publisher: Elsevier
    Status:
    Published

  4. Fluorescent analogs of trypsin inhibitor SFTI-1 isolated from sunflower seeds - synthesis and applications

    Authors:
    Lesner A., Karna N., Łęgowska A., Wysocka M., Guzow K., Sieradzan A., Sieńczyk M., Trzonkowski P., Pikuła P., Zieliński M., Kosikowska P., Łęgowska Ł, Dębowski D., Wiczk W., Rolka K.
    Academic press:
    Biopolymers (year: 2014, volume: 102, pages: 124-135), Publisher: Wiley Periodicals, Inc.
    Status:
    Published
    DOI:
    10.1002/bio.22442 – link to the publication

  5. Peptide splicing in a double-sequence analogue of trypsin inhibitor SFTI-1 substituted in the P1 positions by peptoid monomers

    Authors:
    Karna N., Dębowski D., Łęgowska A., Bąchor R., Szewczuk Z., Rolka K.
    Academic press:
    Biopolymers (year: 2015, volume: 104, pages: 206-2012), Publisher: Wiley Periodicals, Inc
    Status:
    Published

  6. Investigation of protease catalyzed peptide splicing in analogues of sunflower trypsin inhibitor 1 (SFTI-1)

    Authors:
    Karna N., Malicki S., Dębowski D., Golik P., Gitlin A., Grudnik P., Łęgowska A., Wladyka B., Brzozowski K., Dubin G., Rolka K.
    Status:
    Accepted for publication

Articles in post-conference publications (2)

  1. Fluorescent analogues of SFTI-1 – synthesis and application

    Authors:
    Łęgowska A., Wysocka M., Lesner A., Filipowicz M., Sieradzan A., Pikuła M., Trzonkowski P.
    Conference:
    32nd European Peptide Symposium (year: 2012, pages: 362-363), Publisher: European Peptide Society
    Date:
    conference 2 - 7 września
    Status:
    Published

  2. The analogues of SFTI-1 modified in the P1 position by, β- and γ-amino acids and N-substituted β-alanines

    Authors:
    Łęgowska A., Łukajtis R., Filipowicz M., Łęgowska M., Dębowski D., Wysocka M., Lesner A., Rolka K.
    Conference:
    32nd European Peptide Symposium (year: 2012, pages: 398-399), Publisher: European Peptide Society
    Date:
    conference 2 - 7 września
    Status:
    Published

Book publications / chapters in book publications (1)

  1. Peptidic plant origin inhibitors of serine proteinases

    Authors:
    K. Rolka, A. Lesner, A. Łęgowska, M. Wysocka
    Book:
    Antitumor Potential and Other Emerging Medicinal Properties of Natural Compounds (year: 2013, volume: Brak, pages: 187 – 204), Publisher: Springer, ISBN: 978-94-007-6214-5 (eBook); ISNB 978-94-007-6213-8
    Status:
    Published

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Graphic design and implementation: Jakub Piotrowski