Chemical syntesis and evaluation of biochemical properties of 7-methyloguanosine 5'-diphosphate analogs as inhibitors of decapping enzymes
2011/01/N/NZ1/04326
Keywords
Descriptors
- NZ1_2: Biochemia
- ST5_16: Chemia biologiczna
- NZ1_4: Biologia strukturalna
Panel
NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology
Host institution
Uniwersytet Warszawski, Wydział Fizyki
Voivodeship: mazowieckie
Principal investigator (from the host institution)
Number of co-investigators in the project: 2
Call
PRELUDIUM 1 – announced on 2011-03-15
- Amount awarded
- 128 000 PLN
- Project start date
- 2011-12-12
- Project end date
- 2014-12-11
- Project duration
- 36 months (the same as in the proposal)
- Project status
- Project settled
Equipment purchased [PL]
- kolektor frakcji. Cost: 24 000 PLN
Information in the final report
Publication in academic press/journals (1)
-
Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes
- Authors:
- Kowalska, J., A. Wypijewska del Nogal, Z.M. Darzynkiewicz, J. Buck, C. Nicola, A. Kuhn, M. Lukaszewicz, J. Zuberek, M. Strenkowska, M. Ziemniak, M. Maciejczyk, E. Bojarska, R.E. Rhoads, E. Darzynkiewicz, U. Sahin, J. Jemielity
- Academic press:
- Nucleic Acids Research (year: 2014, volume: 42, pages: 10245-10264), Publisher: Oxford University Press
- Status:
- Published
- DOI:
- 10.1093/nar/gku757 – link to the publication
Articles in post-conference publications (1)
-
Utility of chemically modified cap analogues in studying Dcp1/2 decapping complex mechanism of action
- Authors:
- M Ziemniak, J. Mudridge, J. Kowalska, A. Stelmachowska, J. Zuberek, E. Darzynkiewicz, J.D. Gross, R.E. Rhoads, J. Jemielity.
- Conference:
- 16th Symposium on Chemistry of Nucleic Acid Components (year: 2014, pages: 155-158), Publisher: Acad Sci Czech Republic, Inst Organic Chem & Biochemistry
- Date:
- conference 8-13.06.2014
- Status:
- Published