Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Chemical syntesis and evaluation of biochemical properties of 7-methyloguanosine 5'-diphosphate analogs as inhibitors of decapping enzymes

2011/01/N/NZ1/04326

Keywords:

synthesis of nucleotides mRNA 5' terminus mRNA turnover gene therapy

Descriptors:

  • NZ1_2: Biochemistry
  • ST5_16:
  • NZ1_4: Structural biology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Warszawski, Wydział Fizyki

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Marcin Ziemniak 

Number of co-investigators in the project: 2

Call: PRELUDIUM 1 - announced on 2011-03-15

Amount awarded: 128 000 PLN

Project start date (Y-m-d): 2011-12-12

Project end date (Y-m-d): 2014-12-11

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. kolektor frakcji (24 000 PLN)

Information in the final report

  • Publication in academic press/journals (1)
  • Articles in post-conference publications (1)
  1. Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes
    Authors:
    Kowalska, J., A. Wypijewska del Nogal, Z.M. Darzynkiewicz, J. Buck, C. Nicola, A. Kuhn, M. Lukaszewicz, J. Zuberek, M. Strenkowska, M. Ziemniak, M. Maciejczyk, E. Bojarska, R.E. Rhoads, E. Darzynkiewicz, U. Sahin, J. Jemielity
    Academic press:
    Nucleic Acids Research (rok: 2014, tom: 42, strony: 10245-10264), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gku757 - link to the publication
  1. Utility of chemically modified cap analogues in studying Dcp1/2 decapping complex mechanism of action
    Authors:
    M Ziemniak, J. Mudridge, J. Kowalska, A. Stelmachowska, J. Zuberek, E. Darzynkiewicz, J.D. Gross, R.E. Rhoads, J. Jemielity.
    Conference:
    16th Symposium on Chemistry of Nucleic Acid Components (rok: 2014, ), Wydawca: Acad Sci Czech Republic, Inst Organic Chem & Biochemistry
    Data:
    konferencja 8-13.06.2014
    Status:
    Published

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