Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Bioactive organoselenium compounds in self-organizing systems: design, synthesis and biological evaluation

2013/09/D/ST5/03814

Keywords:

organoselenium compounds antibacterial activity antifungal activity H+-ATase inhibitors cytotoxicity mutagenicity hemolysis drug carriers solubilization microemulsions emulsions polymeric micelles

Descriptors:

  • ST5_16:
  • ST5_23:
  • ST5_15:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Politechnika Wrocławska, Wydział Chemiczny

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Magdalena Piętka-Ottlik 

Number of co-investigators in the project: 5

Call: SONATA 5 - announced on 2013-03-15

Amount awarded: 398 000 PLN

Project start date (Y-m-d): 2014-03-11

Project end date (Y-m-d): 2017-09-10

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Vortex IKA Genius 3 z przystawkami (2 000 PLN)
  2. Dygestorium z lampą UV (445 PLN)
  3. Komora laminarna II klasy bezpieczeństwa, model BIO 130 CYTO firmy ALPINA (28 000 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (15)
  1. Topical delivery of ebselen encapsulated in biopolymeric nanocapsules: drug repurposing enhanced antifungal activity
    Authors:
    Anna Jaromin, Robert Zarnowski, Magdalena Piętka-Ottlik, David R. Andes, Jerzy Gubernator
    Academic press:
    Nanomedicine (Lond.) (rok: 2018, tom: 13(10), strony: 1139-1155), Wydawca: Future Medicine Ltd
    Status:
    Published
    DOI:
    10.2217/nnm-2017-0337 - link to the publication
  2. Reaction of bis[(2-chlorocarbonyl)phenyl] Diselenide with Phenols, Aminophenols, and Other Amines towards Diphenyl Diselenides with Antimicrobial and Antiviral Properties
    Authors:
    Mirosław Giurg, Anna Gołąb, Jakub Suchodolski, Rafał Kaleta, Anna Krasowska, Egbert Piasecki, Magdalena Piętka-Ottlik
    Academic press:
    Molecules (rok: 2017, tom: 22(6), strony: 974-995), Wydawca: MDPI, Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/molecules22060974 - link to the publication
  3. Ebselen oxide attenuates mechlorethamine dermatotoxicity in the mouse ear vesicant model
    Authors:
    Hemanta C Rao Tumu, Benedette J. Cuffari, Maria A. Pino, Jerzy Palus, Magdalena Piętka-Ottlik, Blase Billack
    Academic press:
    Drug and Chemical Toxicology (rok: 2018, tom: nie dotyczy, strony: nie dotyczy), Wydawca: Taylor & Francis
    Status:
    Accepted for publication
    DOI:
    10.1080/01480545.2018.1488858 - link to the publication
  4. Antifungal organoselenium compound loaded nanoemulsions stabilized by bifunctional cationic surfactants
    Authors:
    Magdalena Piętka-Ottlik. Agnieszka Lewińska, Anna Jaromin, Anna Krasowska, Kazimiera A. Wilk
    Academic press:
    Colloids and Surfaces A: Physicochemical and Engineering Aspects (rok: 2016, tom: 510, strony: 53-62), Wydawca: Elsevier Ltd
    Status:
    Published
    DOI:
    10.1016/j.colsurfa.2016.07.062 - link to the publication
  5. In vitro assessment of the growth and plasma membrane H+-ATPase inhibitory activity of ebselen and structurally related selenium- and sulfur-containing compounds in Candida albicans
    Authors:
    Natalie N. Orie, Andrew R. Warren, Jovana Basaric, Cesar Lau-Cam, Magdalena Piętka-Ottlik, Jacek Młochowski, Blase Billack
    Academic press:
    Journal of Biochemical and Molecular Toxicology (rok: 2017, tom: TBD, strony: TBD), Wydawca: Wiley Periodicals, Inc.
    Status:
    Published
    DOI:
    10.1002/jbt.21892 - link to the publication
  6. Synthesis of new alkylated and methoxylated analogues of ebselen with antiviral and antimicrobial properties
    Authors:
    Magdalena Piętka-Ottlik, Małgorzata Burda-Grabowska, Marta Woźna, Joanna Waleńska, Rafał Kaleta, Ewa Zaczyńska, Egbert Piasecki, Mirosław Giurg
    Academic press:
    ARKIVOC (rok: 2017, tom: ii, strony: 546-556), Wydawca: ARKAT USA, Inc.
    Status:
    Published
    DOI:
    10.3998/ark.5550190.p009.797 - link to the publication
  1. Analogi ebselenu: synteza i właściwości przeciwdrobnoustrojowe
    Authors:
    Magdalena Piętka-Ottlik, Anna Krasowska, Anna Jaromin
    Conference:
    IX Multidyscyplinarna Konferencja Nauki o Leku (rok: 2014, ), Wydawca: Instytut Farmaceutyczny
    Data:
    konferencja 11-15.05.2014
    Status:
    Published
  2. Antimicrobial lipid nanocarriers loaded with organoselenium compounds: Fabrication, physical stability and biological evaluation
    Authors:
    Agata Pucek, Magdalena Piętka-Ottlik, Joanna Szczepaniak, Anna Krasowska, Kazimiera A. Wilk
    Conference:
    31th Conference of the European Colloid and Interface Society (ECIS) (rok: 2017, ), Wydawca: Elsevier Ltd
    Data:
    konferencja 03-08.09.2017
    Status:
    Published
  3. Hemolytic activity of organoselenium compounds
    Authors:
    Martyna Jasik, Magdalena Piętka-Ottlik, Anna Jaromin
    Conference:
    XVI National Academic Seminar of Biotechnology Students & VI International Conference of Biotechnology Students (rok: 2014, ), Wydawca: Akademickie Stowarzyszenie Studentów Biotechnologii
    Data:
    konferencja 21-23.11.2014
    Status:
    Published
  4. Polymeric carriers for bioactive organoselenium compounds
    Authors:
    Magdalena Piętka-Ottlik, Anna Jaromin
    Conference:
    Fifth International Symposium Frontiers in Polymer Science In association with the journal polymer (rok: 2017, ), Wydawca: Elsevier Ltd
    Data:
    konferencja 17-19.05.2017
    Status:
    Published
  5. Polymeric micelles as nanocarriers for ebselen analogues
    Authors:
    Magdalena Piętka-Ottlik
    Conference:
    4th Nano Today Conference (rok: 2015, ), Wydawca: Elsevier Ltd
    Data:
    konferencja 06-11.12.2015
    Status:
    Published
    DOI:
    link to the publication
  6. Polymeric nanocarriers loaded with organoselenium compounds: fabrication and antimicrobial evaluation
    Authors:
    Magdalena Piętka-Ottlik, Jakub Suchodolski, Anna Krasowska
    Conference:
    31th Conference of the European Colloid and Interface Society (ECIS) (rok: 2017, ), Wydawca: Elsevier Ltd
    Data:
    konferencja 03-08.09.2017
    Status:
    Published
  7. Comparison of inhibitory activities of organoselenium compounds on acetylcholinesterase from Electrophorus electricus (electric eel) and human erythrocyte ghosts
    Authors:
    Martyna Jasik, Magdalena Piętka-Ottlik, Anna Jaromin
    Conference:
    IV International Conference of Biophysics Students 2015 (rok: 2015, ), Wydawca: Jagiellonian University, Biophysics Students' Association "Nobel"
    Data:
    konferencja 22-24.05.2015
    Status:
    Published
    DOI:
    link to the publication
  8. Evaluation of Polysorbate based microemulsions in the presence of various organoselenium compounds
    Authors:
    Magdalena Piętka-Ottlik, Katarzyna Bem
    Conference:
    4th Nano Today Conference (rok: 2015, ), Wydawca: Elsevier Ltd
    Data:
    konferencja 06-11.12.2015
    Status:
    Published
    DOI:
    link to the publication
  9. Biopolymeric nanocapsules for ebselen topical delivery
    Authors:
    Anna Jaromin, Robert Żarnowski, Magdalena Piętka-Ottlik, Eddie Dominguez, David R. Andes
    Conference:
    Fifth International Symposium Frontiers in Polymer Science In association with the journal polymer (rok: 2017, ), Wydawca: Elsevier Ltd
    Data:
    konferencja 17-19.05.2017
    Status:
    Published
  10. Preparation and evaluation of emulsion carriers for ebselen topical application
    Authors:
    Anna Jaromin, Magdalena Piętka-Ottlik
    Conference:
    13th International Conference on the Chemistry of Selenium and Tellurium (ICCST-13) (rok: 2016, ), Wydawca: Gifu University
    Data:
    konferencja 23-27.05.2016
    Status:
    Published
  11. Characterization of nanoemulsion-based nanocarriers for organoselenium compound delivery
    Authors:
    Magdalena Piętka-Ottlik, Agnieszka Lewińska, Anna Jaromin, Kazimiera A. Wilk
    Conference:
    29th Conference of the European Colloid and Interface Society (ECIS) (rok: 2015, ), Wydawca: Elsevier Ltd
    Data:
    konferencja 06-11.09.2015
    Status:
    Published
    DOI:
    link to the publication
  12. Determination of interactions of ebselen analogues with model membranes
    Authors:
    Anna Jaromin, Martyna Jasik, Magdalena Pietka-Ottlik
    Conference:
    15th Tetrahedron Symposium, Challenges in Bioorganic and Organic Medicinal Chemistry (rok: 2014, ), Wydawca: Elsevier Ltd
    Data:
    konferencja 28-31.10.2014
    Status:
    Published
  13. Exploring polymeric micelles for improved delivery of benzisoselenazol-3(2H)-ones
    Authors:
    Magdalena Piętka-Ottlik, Katarzyna Bem
    Conference:
    13th International Conference on the Chemistry of Selenium and Tellurium (ICCST-13) (rok: 2016, ), Wydawca: Gifu University
    Data:
    konferencja 23-27.05.2016
    Status:
    Published
    DOI:
    link to the publication
  14. Organoselenium compounds with antimicrobial activity
    Authors:
    Magdalena Piętka-Ottlik, Anna Krasowska, Anna Jaromin, Jerzy Palus
    Conference:
    15th Tetrahedron Symposium, Challenges in Bioorganic and Organic Medicinal Chemistry (rok: 2014, ), Wydawca: Elsevier Ltd
    Data:
    konferencja 28-31.10.2014
    Status:
    Published
  15. Synthesis of ebselenols and their open chain analogues with antibacterial properties
    Authors:
    Anna Gołąb, Jakub Suchodolski, Anna Krasowska, Magdalena Piętka-Ottlik, Mirosław Giurg
    Conference:
    6th Workshop of SeS Redox and Catalysis (rok: 2017, ), Wydawca: Oficyna Wydawnicza Politechniki Wrocławskiej
    Data:
    konferencja 22-23.09.2017
    Status:
    Published

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy