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Bioactive organoselenium compounds in self-organizing systems: design, synthesis and biological evaluation

2013/09/D/ST5/03814

Keywords

Descriptors

  • ST5_16: Chemia biologiczna
  • ST5_23: Chemia organiczna
  • ST5_15: Chemia koloidów

Panel

ST5 – Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution

Politechnika Wrocławska, Wydział Chemiczny

Voivodeship: dolnośląskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Magdalena Piętka-Ottlik

Number of co-investigators in the project: 5

Call

SONATA 5 – announced on 2013-03-15

Amount awarded
398 000 PLN
Project start date
2014-03-11
Project end date
2017-09-10
Project duration
42 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Dygestorium z lampą UV. Cost: 445 PLN
  2. Komora laminarna II klasy bezpieczeństwa, model BIO 130 CYTO firmy ALPINA. Cost: 28 000 PLN
  3. Vortex IKA Genius 3 z przystawkami. Cost: 2 000 PLN

Information in the final report

Publication in academic press/journals (6)

  1. Topical delivery of ebselen encapsulated in biopolymeric nanocapsules: drug repurposing enhanced antifungal activity

    Authors:
    Anna Jaromin, Robert Zarnowski, Magdalena Piętka-Ottlik, David R. Andes, Jerzy Gubernator
    Academic press:
    Nanomedicine (Lond.) (year: 2018, volume: 13(10), pages: 1139-1155), Publisher: Future Medicine Ltd
    Status:
    Published
    DOI:
    10.2217/nnm-2017-0337 – link to the publication

  2. Synthesis of new alkylated and methoxylated analogues of ebselen with antiviral and antimicrobial properties

    Authors:
    Magdalena Piętka-Ottlik, Małgorzata Burda-Grabowska, Marta Woźna, Joanna Waleńska, Rafał Kaleta, Ewa Zaczyńska, Egbert Piasecki, Mirosław Giurg
    Academic press:
    ARKIVOC (year: 2017, volume: ii, pages: 546-556), Publisher: ARKAT USA, Inc.
    Status:
    Published
    DOI:
    10.3998/ark.5550190.p009.797 – link to the publication

  3. Antifungal organoselenium compound loaded nanoemulsions stabilized by bifunctional cationic surfactants

    Authors:
    Magdalena Piętka-Ottlik. Agnieszka Lewińska, Anna Jaromin, Anna Krasowska, Kazimiera A. Wilk
    Academic press:
    Colloids and Surfaces A: Physicochemical and Engineering Aspects (year: 2016, volume: 510, pages: 53-62), Publisher: Elsevier Ltd
    Status:
    Published
    DOI:
    10.1016/j.colsurfa.2016.07.062 – link to the publication

  4. Reaction of bis[(2-chlorocarbonyl)phenyl] Diselenide with Phenols, Aminophenols, and Other Amines towards Diphenyl Diselenides with Antimicrobial and Antiviral Properties

    Authors:
    Mirosław Giurg, Anna Gołąb, Jakub Suchodolski, Rafał Kaleta, Anna Krasowska, Egbert Piasecki, Magdalena Piętka-Ottlik
    Academic press:
    Molecules (year: 2017, volume: 22(6), pages: 974-995), Publisher: MDPI, Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/molecules22060974 – link to the publication

  5. In vitro assessment of the growth and plasma membrane H+-ATPase inhibitory activity of ebselen and structurally related selenium- and sulfur-containing compounds in Candida albicans

    Authors:
    Natalie N. Orie, Andrew R. Warren, Jovana Basaric, Cesar Lau-Cam, Magdalena Piętka-Ottlik, Jacek Młochowski, Blase Billack
    Academic press:
    Journal of Biochemical and Molecular Toxicology (year: 2017, volume: TBD, pages: TBD), Publisher: Wiley Periodicals, Inc.
    Status:
    Published
    DOI:
    10.1002/jbt.21892 – link to the publication

  6. Ebselen oxide attenuates mechlorethamine dermatotoxicity in the mouse ear vesicant model

    Authors:
    Hemanta C Rao Tumu, Benedette J. Cuffari, Maria A. Pino, Jerzy Palus, Magdalena Piętka-Ottlik, Blase Billack
    Status:
    Accepted for publication

Articles in post-conference publications (15)

  1. Polymeric carriers for bioactive organoselenium compounds

    Authors:
    Magdalena Piętka-Ottlik, Anna Jaromin
    Conference:
    Fifth International Symposium Frontiers in Polymer Science In association with the journal polymer (year: 2017, pages: nie dotyczy), Publisher: Elsevier Ltd
    Date:
    conference 17-19.05.2017
    Status:
    Published

  2. Biopolymeric nanocapsules for ebselen topical delivery

    Authors:
    Anna Jaromin, Robert Żarnowski, Magdalena Piętka-Ottlik, Eddie Dominguez, David R. Andes
    Conference:
    Fifth International Symposium Frontiers in Polymer Science In association with the journal polymer (year: 2017, pages: nie dotyczy), Publisher: Elsevier Ltd
    Date:
    conference 17-19.05.2017
    Status:
    Published

  3. Exploring polymeric micelles for improved delivery of benzisoselenazol-3(2H)-ones

    Authors:
    Magdalena Piętka-Ottlik, Katarzyna Bem
    Conference:
    13th International Conference on the Chemistry of Selenium and Tellurium (ICCST-13) (year: 2016, pages: nie dotyczy), Publisher: Gifu University
    Date:
    conference 23-27.05.2016
    Status:
    Published

  4. Synthesis of ebselenols and their open chain analogues with antibacterial properties

    Authors:
    Anna Gołąb, Jakub Suchodolski, Anna Krasowska, Magdalena Piętka-Ottlik, Mirosław Giurg
    Conference:
    6th Workshop of SeS Redox and Catalysis (year: 2017, pages: nie dotyczy), Publisher: Oficyna Wydawnicza Politechniki Wrocławskiej
    Date:
    conference 22-23.09.2017
    Status:
    Published

  5. Antimicrobial lipid nanocarriers loaded with organoselenium compounds: Fabrication, physical stability and biological evaluation

    Authors:
    Agata Pucek, Magdalena Piętka-Ottlik, Joanna Szczepaniak, Anna Krasowska, Kazimiera A. Wilk
    Conference:
    31th Conference of the European Colloid and Interface Society (ECIS) (year: 2017, pages: nie dotyczy), Publisher: Elsevier Ltd
    Date:
    conference 03-08.09.2017
    Status:
    Published

  6. Polymeric nanocarriers loaded with organoselenium compounds: fabrication and antimicrobial evaluation

    Authors:
    Magdalena Piętka-Ottlik, Jakub Suchodolski, Anna Krasowska
    Conference:
    31th Conference of the European Colloid and Interface Society (ECIS) (year: 2017, pages: nie dotyczy), Publisher: Elsevier Ltd
    Date:
    conference 03-08.09.2017
    Status:
    Published

  7. Hemolytic activity of organoselenium compounds

    Authors:
    Martyna Jasik, Magdalena Piętka-Ottlik, Anna Jaromin
    Conference:
    XVI National Academic Seminar of Biotechnology Students & VI International Conference of Biotechnology Students (year: 2014, pages: 108), Publisher: Akademickie Stowarzyszenie Studentów Biotechnologii
    Date:
    conference 21-23.11.2014
    Status:
    Published

  8. Determination of interactions of ebselen analogues with model membranes

    Authors:
    Anna Jaromin, Martyna Jasik, Magdalena Pietka-Ottlik
    Conference:
    15th Tetrahedron Symposium, Challenges in Bioorganic and Organic Medicinal Chemistry (year: 2014, pages: nie dotyczy), Publisher: Elsevier Ltd
    Date:
    conference 28-31.10.2014
    Status:
    Published

  9. Organoselenium compounds with antimicrobial activity

    Authors:
    Magdalena Piętka-Ottlik, Anna Krasowska, Anna Jaromin, Jerzy Palus
    Conference:
    15th Tetrahedron Symposium, Challenges in Bioorganic and Organic Medicinal Chemistry (year: 2014, pages: nie dotyczy), Publisher: Elsevier Ltd
    Date:
    conference 28-31.10.2014
    Status:
    Published

  10. Characterization of nanoemulsion-based nanocarriers for organoselenium compound delivery

    Authors:
    Magdalena Piętka-Ottlik, Agnieszka Lewińska, Anna Jaromin, Kazimiera A. Wilk
    Conference:
    29th Conference of the European Colloid and Interface Society (ECIS) (year: 2015, pages: nie dotyczy), Publisher: Elsevier Ltd
    Date:
    conference 06-11.09.2015
    Status:
    Published

  11. Comparison of inhibitory activities of organoselenium compounds on acetylcholinesterase from Electrophorus electricus (electric eel) and human erythrocyte ghosts

    Authors:
    Martyna Jasik, Magdalena Piętka-Ottlik, Anna Jaromin
    Conference:
    IV International Conference of Biophysics Students 2015 (year: 2015, pages: nie dotyczy), Publisher: Jagiellonian University, Biophysics Students' Association Nobel
    Date:
    conference 22-24.05.2015
    Status:
    Published

  12. Evaluation of Polysorbate based microemulsions in the presence of various organoselenium compounds

    Authors:
    Magdalena Piętka-Ottlik, Katarzyna Bem
    Conference:
    4th Nano Today Conference (year: 2015, pages: nie dotyczy), Publisher: Elsevier Ltd
    Date:
    conference 06-11.12.2015
    Status:
    Published

  13. Polymeric micelles as nanocarriers for ebselen analogues

    Authors:
    Magdalena Piętka-Ottlik
    Conference:
    4th Nano Today Conference (year: 2015, pages: nie dotyczy), Publisher: Elsevier Ltd
    Date:
    conference 06-11.12.2015
    Status:
    Published

  14. Preparation and evaluation of emulsion carriers for ebselen topical application

    Authors:
    Anna Jaromin, Magdalena Piętka-Ottlik
    Conference:
    13th International Conference on the Chemistry of Selenium and Tellurium (ICCST-13) (year: 2016, pages: nie dotyczy), Publisher: Gifu University
    Date:
    conference 23-27.05.2016
    Status:
    Published

  15. Analogi ebselenu: synteza i właściwości przeciwdrobnoustrojowe

    Authors:
    Magdalena Piętka-Ottlik, Anna Krasowska, Anna Jaromin
    Conference:
    IX Multidyscyplinarna Konferencja Nauki o Leku (year: 2014, pages: 24), Publisher: Instytut Farmaceutyczny
    Date:
    conference 11-15.05.2014
    Status:
    Published

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