Projects funded by the NCN
Synthesis and evaluation of PD-L1 inhibitors based on mixed mode scaffolds containing amino acid derivatives, short peptides and peptidomimetics
2020/39/D/ST4/01344
Keywords:
peptidomimetics amino aicd immunooncology small-molecular inhibitors PD-1/PD-L1
Descriptors:
- ST4_008:
- ST4_009:
- NZ1_002:
Panel:
ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development
Host institution :
Uniwersytet Jagielloński, Wydział Chemii
woj. małopolskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 4
Call: SONATA 16 - announced on 2020-09-15
Amount awarded: 1 086 800 PLN
Project start date (Y-m-d): 2021-07-15
Project end date (Y-m-d): 2025-07-14
Project duration:: 48 months (the same as in the proposal)
Project status: Project completed
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (3)
- Exploring the Surface of the Ectodomain of the PD-L1 Immune Checkpoint with Small-Molecule FragmentsAuthors:Radoslaw Kitel, Ismael Rodríguez, Xabier del Corte, Jack Atmaj, Magdalena Żarnik, Ewa Surmiak, Damian Muszak, Katarzyna Magiera-Mularz, Grzegorz M. Popowicz, Tad A. Holak, and Bogdan Musielak*Academic press:ACS Chemical Biology (rok: 2022, tom: 17, strony: 2655-2663), Wydawca: ACS PublicationsStatus:PublishedDOI:10.1021/acschembio.2c00583 - link to the publication
- PD-L1 inhibitors: different classes, activities, and mechanisms of actionAuthors:Ewa Surmiak, Katarzyna Magiera-Mularz, Bogdan Musielak, Damian Muszak, Justyna Kocik-Krol, Radoslaw Kitel, Jacek Plewka, Tad A Holak, Lukasz SkalniakAcademic press:International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 11797), Wydawca: MDPIStatus:PublishedDOI:10.3390/ijms222111797 - link to the publication
- Solubilizer Tag Effect on PD-L1/Inhibitor Binding Properties for m-Terphenyl DerivativesAuthors:Ewa Surmiak, Julia Ząber, Jacek Plewka, Grzegorz Wojtanowicz, Justyna Kocik-Krol, Oskar Kruc, Damian Muszak, Ismael Rodríguez, Bogdan Musielak, Monica Viviano, Sabrina Castellano, Lukasz Skalniak, Katarzyna Magiera-Mularz, Tad A. Holak, Justyna Kalinowska-TłuścikAcademic press:ACS Medicinal Chemistry Letters (rok: 2024, tom: 15, strony: 36-44), Wydawca: ACSStatus:PublishedDOI:10.1021/acsmedchemlett.3c00306 - link to the publication