Synthesis and evaluation of PD-L1 inhibitors based on mixed mode scaffolds containing amino acid derivatives, short peptides and peptidomimetics
2020/39/D/ST4/01344
Keywords
Descriptors
- ST4_008: Chemia organiczna
- ST4_009: Chemia biologiczna
- NZ1_002: Biochemia
Panel
ST4 – Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development
Host institution
Uniwersytet Jagielloński, Wydział Chemii
Voivodeship: małopolskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 4
Call
SONATA 16 – announced on 2020-09-15
- Amount awarded
- 1 086 800 PLN
- Project start date
- 2021-07-15
- Project end date
- 2025-12-14
- Project duration
- 53 months (the same as in the proposal)
- Project status
- Project completed
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
Publication in academic press/journals (3)
-
Solubilizer Tag Effect on PD-L1/Inhibitor Binding Properties for m-Terphenyl Derivatives
- Authors:
- Ewa Surmiak, Julia Ząber, Jacek Plewka, Grzegorz Wojtanowicz, Justyna Kocik-Krol, Oskar Kruc, Damian Muszak, Ismael Rodríguez, Bogdan Musielak, Monica Viviano, Sabrina Castellano, Lukasz Skalniak, Katarzyna Magiera-Mularz, Tad A. Holak, Justyna Kalinowska-Tłuścik
- Academic press:
- ACS Medicinal Chemistry Letters (year: 2024, volume: 15, pages: 36-44), Publisher: ACS
- Status:
- Published
- DOI:
- 10.1021/acsmedchemlett.3c00306 – link to the publication
-
PD-L1 inhibitors: different classes, activities, and mechanisms of action
- Authors:
- Ewa Surmiak, Katarzyna Magiera-Mularz, Bogdan Musielak, Damian Muszak, Justyna Kocik-Krol, Radoslaw Kitel, Jacek Plewka, Tad A Holak, Lukasz Skalniak
- Academic press:
- International Journal of Molecular Sciences (year: 2021, volume: 22, pages: 11797), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/ijms222111797 – link to the publication
-
Exploring the Surface of the Ectodomain of the PD-L1 Immune Checkpoint with Small-Molecule Fragments
- Authors:
- Radoslaw Kitel, Ismael Rodríguez, Xabier del Corte, Jack Atmaj, Magdalena Żarnik, Ewa Surmiak, Damian Muszak, Katarzyna Magiera-Mularz, Grzegorz M. Popowicz, Tad A. Holak, and Bogdan Musielak*
- Academic press:
- ACS Chemical Biology (year: 2022, volume: 17, pages: 2655-2663), Publisher: ACS Publications
- Status:
- Published
- DOI:
- 10.1021/acschembio.2c00583 – link to the publication