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Theoretical prediction, chemical synthesis and biological analysis of a novel class of HSPA5 inhibitors

2023/49/B/ST4/03288

Keywords:

docking molecular dynamics chemical synthesis inhibitors heat shock protein HSPA5,

Descriptors:

  • ST4_03:
  • ST4_04:
  • ST5_08:

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Centrum Badań Molekularnych i Makromolekularnych PAN

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Arkadiusz Chworoś 

Number of co-investigators in the project: 6

Call: OPUS 25 - announced on 2023-03-16

Amount awarded: 3 161 120 PLN

Project start date (Y-m-d): 2024-04-02

Project end date (Y-m-d): 2028-04-01

Project duration:: 48 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (2)
  1. Influence of heterochirality on the structure, dynamics, biological properties of cyclic(PFPF) tetrapeptides obtained by solvent-free ball mill mechanosynthesis
    Authors:
    Irena Bak-Sypien, Tomasz Pawlak, Piotr Paluch, Aneta Wroblewska, Rafał Dolot, Aleksandra Pawlowicz, Małgorzata Szczesio, Ewelina Wielgus, Sławomir Kaźmierski, Marcin Górecki, Roza Pawlowska, Arkadiusz Chworos, Marek J Potrzebowski
    Academic press:
    Scientific Reports (rok: 2024, tom: 14, strony: 12825), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-024-63552-4 - link to the publication
  2. Double-modified, thio and methylene ATP analogue facilitates wound healing in vitro and in vivo
    Authors:
    Roza Pawlowska, Ewa Radzikowska-Cieciura, Sepideh Jafari, Julia Fastyn, Eliza Korkus, Edyta Gendaszewska-Darmach, Gangyin Zhao, Ewa Snaar-Jagalska, Arkadiusz Chworos
    Academic press:
    Scientific Reports (rok: 2024, tom: 14, strony: 13148), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-024-63759-5 - link to the publication

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