Theoretical prediction, chemical synthesis and biological analysis of a novel cl

Theoretical prediction, chemical synthesis and biological analysis of a novel class of HSPA5 inhibitors

2023/49/B/ST4/03288

Keywords

Descriptors

ST4_03: Struktura i architektura molekularna
ST4_04: Chemia teoretyczna i obliczeniowa
ST5_08: Biomateriały, materiały biozgodne

Panel

ST4 – Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution

Centrum Badań Molekularnych i Makromolekularnych PAN

Voivodeship: łódzkie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Arkadiusz Chworoś

Number of co-investigators in the project: 6

Call

OPUS 25 – announced on 2023-03-16

Amount awarded: 3 161 120 PLN
Project start date: 2024-04-02
Project end date: 2028-04-01
Project duration: 48 months (the same as in the proposal)
Project status: Pending project

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (2)

Double-modified, thio and methylene ATP analogue facilitates wound healing in vitro and in vivo

Authors:
Roza Pawlowska, Ewa Radzikowska-Cieciura, Sepideh Jafari, Julia Fastyn, Eliza Korkus, Edyta Gendaszewska-Darmach, Gangyin Zhao, Ewa Snaar-Jagalska, Arkadiusz Chworos

Academic press:
Scientific Reports (year: 2024, volume: 14, pages: 13148), Publisher: Nature Publishing Group

Status:
Published

DOI:
10.1038/s41598-024-63759-5 – link to the publication
Influence of heterochirality on the structure, dynamics, biological properties of cyclic(PFPF) tetrapeptides obtained by solvent-free ball mill mechanosynthesis

Authors:
Irena Bak-Sypien, Tomasz Pawlak, Piotr Paluch, Aneta Wroblewska, Rafał Dolot, Aleksandra Pawlowicz, Małgorzata Szczesio, Ewelina Wielgus, Sławomir Kaźmierski, Marcin Górecki, Roza Pawlowska, Arkadiusz Chworos, Marek J Potrzebowski

Academic press:
Scientific Reports (year: 2024, volume: 14, pages: 12825), Publisher: Nature Publishing Group

Status:
Published

DOI:
10.1038/s41598-024-63552-4 – link to the publication

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