Projects search

Carborane-linked 20-deoxyuridine 50-O-triphosphate as building block for polymerase synthesis of carborane-modified DNA

Authors:

Jana Balintová , Anna Simonova, Magdalena Białek-Pietras , Agnieszka Olejniczak , Zbigniew J. Lesnikowski, Michal Hocek

Academic press:

Bioorganic and Medicinal Chemsitry Letters (year: 2017, volume: 27, pages: 4786-4788), Publisher: Elsevier

Status:

Published

DOI:

10.1016/j.bmcl.2017.09.064 – link to the publication

Disubstituted cobalt bis(1,2-dicarbollide)(-I) terminal alkynes: Synthesis, reactivity in the Sonogashira reaction and application in the synthesis of cobalt bis(1,2-dicarbollide)(-I) nucleoside conjugates

Authors:

Irina Kosenko, Ivan Ananyev, Anna Druzina, Ivan Godovikov, Julia Laskova, Vladimir Bregadze, Miroslawa Studzinska, Edyta Paradowska, Zbigniew J. Lesnikowski, Andrey Semioshkin

Academic press:

Journal of Organometallic Chemistry (year: 2017, volume: 849-850, pages: 142-149), Publisher: Elsevier

Status:

Published

DOI:

10.1016/j.jorganchem.2017.02.030 – link to the publication

Reactions of closo-dodecaborate amines. Towards novel bis-(closo-dodecaborates) and closo-dodecaborate conjugates with lipids and non-natural nucleosides

Authors:

Julia Laskova, Alexandra Kozlova, Magdalena Białek-Pietras, Mirosława Studzinska, Edyta Paradowska, Vladimir Bregadze, Zbigniew J. Lesnikowski, Andrey Semioshkin

Academic press:

Journal of Organometalic Chemistry (year: 2016, volume: 807, pages: 2,9E+36), Publisher: Elsevier

Status:

Published

DOI:

10.1016/j.jorganchem.2016.02.009 – link to the publication

Challenges and Opportunities for the Application of Boron Clusters in Drug Design

Authors:

Zbigniew J. Lesń ikowski

Academic press:

Journal of Medicinal Chemistry (year: 2016, volume: 59, pages: 7738−7758), Publisher: American Chemical Society

Status:

Published

DOI:

10.1021/acs.jmedchem.5b01932 – link to the publication

In vitro antileukemic activity of novel adenosine derivatives bearing boron cluster modification

Authors:

Jolanta D. Zołnierczyk, Agnieszka B. Olejniczak, Adam Mieczkowski, Jerzy Z. Błonski, Zofia M. Kilianska, Tadeusz Robak, Zbigniew J. Lesnikowski⇑

Academic press:

Bioorganic and Medicinal Chemistry (year: 2016, volume: 24, pages: 5076–5087), Publisher: Elsevier

Status:

Published

DOI:

10.1016/j.bmc.2016.08.028 – link to the publication

The boron clusters as a platform for new materials: synthesis of functionalized o-carborane (C2B10H12) derivatives incorporating DNA fragments

Authors:

Slawomir Janczak, Agnieszka Olejniczak, Sandra Balabańska, Marcin K. Chmielewski, Marius Lupu, Clara Viñas and Zbigniew J. Lesnikowski

Academic press:

Chemistry - A European Journal (year: 2015, volume: 21, pages: 15118-15122), Publisher: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Status:

Published

DOI:

10.1002/chem.201502822 – link to the publication

Synthesis and in vitro antiviral activity of lipophilic pyrimidine nucleoside/carborane conjugates

Authors:

Magdalena Białek-Pietras, Agnieszka B. Olejniczak, Edyta Paradowska, Mirosława Studzińska, Patrycja Suski, Agnieszka Jabłońska and Zbigniew J. Leśnikowski

Academic press:

Journal of Organometallic Chemistry (year: 2015, volume: 798, pages: 99–105), Publisher: Elsevier

Status:

Published

DOI:

10.1016/j.jorganchem.2015.07.002 – link to the publication

Comparative study of carborane- and phenyl-modified adenosine derivatives as ligands for the A2A and A3 adenosine receptors based on a rigid in silico docking and radioligand replacement assay

Authors:

Marian Vincenzi, Katarzyna Bednarska and Zbigniew J. Leśnikowski

Academic press:

Molecules (year: 2018, volume: 23, pages: 46043), Publisher: MDPI

Status:

Published

DOI:

10.3390/molecules23081846 – link to the publication

Synthesis, susceptibility to enzymatic phosphorylation, cytotoxicity and in vitro antiviral activity of lipophilic pyrimidine nucleoside/carborane conjugates

Authors:

Magdalena Białek-Pietras, Agnieszka B. Olejniczak, Edyta Paradowska, Mirosława Studzińska, Agnieszka Jabłońska, Zbigniew J. Leśnikowski

Academic press:

Journal of Organometallic Chemistry (year: 2018, volume: 865, pages: 166-172), Publisher: Elsevier

Status:

Published

DOI:

10.1016/j.jorganchem.2018.03.026 – link to the publication

Interactions of Boron Clusters and their Derivatives with Serum Albumin

Authors:

Tomasz M. Goszczyński, Krzysztof Fink, Konrad Kowalski, Zbigniew J. Leśnikowski, Janusz Boratyński

Academic press:

Scietific Reports (year: 2017, volume: 7, pages: 46034), Publisher: Nature Publishing Group

Status:

Published

DOI:

10.1038/s41598-017-10314-0 – link to the publication

Inorganic (boron clusters) vs. organic (phenyl) adenosine modifications as potential ligands for adenosine receptors

Authors:

Aleksandra Rembowska, Zbigniew J. Lesnikowski

Conference:

XX International Symposium Advances in the chemistry of heteroorganic compounds (year: 2017, pages: P-024), Publisher: CBMiM PAN

Date:

conference November 23-24

Status:

Published

NOWE POCHODNE ADENOZYNY MODYFIKOWANE KLASTERAMI BORU LUB GRUPAMI FENYLOWYMI I ICH WSTĘPNE BADANIA BIOLOGICZNE

Authors:

Aleksandra Rembowska, Zbigniew J. Lesnikowski

Conference:

60 Zjazd Naukowy Polskiego Towarzystwa Chemicznego (year: 2017, pages: 1024), Publisher: PTCh

Date:

conference 17-21 września

Status:

Published

Comparative evaluation of antiplatelet activity of carborane and phenyl modified novel adenosine receptor ligands

Authors:

Przygodzki T, Vicenzi M, Rembowska A, Saftic D, Bednarska K, Karolczak K, Watala C, Lesnikowski ZJ

Conference:

1st Italian-UK Platelet Meeting 2017 (year: 2017, pages: 23), Publisher: University of Bath

Date:

conference 7th-8th September 2017

Status:

Published

Synteza nowych pochodnych adenozyny modyfikowanych w pozycji N6 i 5' jako potencjalnych ligandów receptorów adenozynowych

Authors:

Aleksandra Rembowska, Zbigniew J. Leśnikowski

Conference:

59 Zjazd Naukowy Polskiego Towarzystwa Chemicznego (year: 2016, pages: 107), Publisher: PTCh

Date:

conference 19-23 września

Status:

Published

DISCOVERY OF NOVEL BORON-CLUSTER MODIFIED NUCLEOSIDES WITH ANTIVIRAL OR ANTICANCER ACTIVITY

Authors:

Zbigniew J. Lesnikowski, Anna Adamska, Magdalena Białek-Pietras, Zofia M. Kiliańska, Agnieszka Olejniczak, Adam Mieczkowski, Edyta Paradowska, Mirosława Studzińska, Jolanta D. Żołnierczyk

Conference:

XXII International Roundtable on Nucleosides, Nucleotides and Nucleic Acids (year: 2016, pages: 35-38), Publisher: International Society of Nucleosides. Nucleotides and Nucleic Acids

Date:

conference 18-22 lipca

Status:

Published

Pochodne adenozyny modyfikowane klasterami boru i ich odpowiedniki fenylowe jako potencjalne ligandy receptorów adenozynowych

Authors:

Aleksandra Rembowska, Zbigniew Leśnikowski

Conference:

V Ogólnopolskie Seminarium Postępy w Chemii Boroorganicznej, Radziejowice (year: 2017, pages: 17), Publisher: Politechnika Warszawska

Date:

conference 7-9 kwietnia

Status:

Published

Boron clusters as a platform for novel nucleoside drug design

Authors:

Zbigniew J. Lesnikowski

Conference:

XVI International Meeting on Boron Chemistry, IMEBORON16 (year: 2017, pages: 68), Publisher: The Chinese University of Hong Kong

Date:

conference 9-13 July

Status:

Published

Adenosine receptor agonists as anti-platelet agents

Authors:

Wolska N, Polak D, Stanczyk L, Przygodzki T, Rozalski M, Lesnikowski Z, Watala C

Conference:

1st Italian-UK Platelet Meeting 2017 (year: 2017, pages: 36), Publisher: University of Bath

Date:

conference 7th-8th September

Status:

Published

New forays into nucleoside drug design – Boron cluster modifications with anticancer, antiviral and purinergic receptors modulating activities

Authors:

Katarzyna Bednarska, Magdalena Białek-Pietras, Zofia M. Kiliańska, Agnieszka Olejniczak, Edyta Paradowska, Mirosława Studzińska, Zofia Sułowska, Jolanta D. Żołnierczyk and Zbigniew J. Lesnikowski*

Conference:

Medicinal Chemistry of Boron Compounds Conference (year: 2015, pages: 20), Publisher: ZING Conferences

Date:

conference 4th– 7th October

Status:

Published

Zastosowania klasterów boru w chemii medycznej - Wyzwania i możliwości

Authors:

Zbigniew J. Leśnikowski

Conference:

58 Zjazd naukowy Polskiego Towarzystwa Chemicznego (year: 2015, pages: 285), Publisher: Polskie Towarzystwo Chemiczne

Date:

conference 21-25 września

Status:

Published

Boron Cluster Modifications with Antiviral, Anticancer, and Modulation of Purinergic Receptors' Activities Based on Nucleoside Structures

Authors:

Anna Adamska‐Bartłomiejczyk, Katarzyna Bednarska, Magdalena Białek‐Pietras, Zofia M. Kiliańska, Adam Mieczkowski, Agnieszka B. Olejniczak, Edyta Paradowska, Mirosława Studzińska, Zofia Sułowska, Jolanta D. Żołnierczyk, Zbigniew J. Lesnikowski

Book:

Boron-Based Compounds: Potential and Emerging Applications in Medicine (year: 2018, volume: 1, pages: 21-34), Publisher: JOHN WILEY & SONS, LTD.

Status:

Published