Projects funded by the NCN

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56 projects found matching your search criteria :

  1. Selected antidepressants toxicity assessment based on in vitro studies of rat spermatocytes and mouse cell lines.

    Call: PRELUDIUM 8 , Panel: NZ7

    Principal investigator: Przemysław Paweł Sołek

    Uniwersytet Rzeszowski, Wydział Biotechnologii

  2. Molecular mechanism of action of antidepressant drugs in the in vitro model of contact allergy in the human cell line Ha...

    Call: PRELUDIUM 7 , Panel: NZ6

    Principal investigator: Katarzyna Curzytek

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  3. Involvement of cyclooxygenase 2 in antidepressant-like effects of metabotropic glutamatergic receptors group I.

    Call: SONATA 7 , Panel: NZ7

    Principal investigator: dr Katarzyna Małgorzata Stachowicz

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  4. Evaluation of the role of transcription factor CREB in the mechanisms antidepressant treatment: study on the novel genet...

    Call: OPUS 7 , Panel: NZ7

    Principal investigator: dr Grzegorz Kreiner

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  5. Research of mechanisms of antidepressant action of group II and III mGlu receptor ligands and their role in inducing rap...

    Call: OPUS 7 , Panel: NZ7

    Principal investigator: dr hab. Agnieszka Pałucha-Poniewiera

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  6. Synthesis, physicochemical and pharmacological properties of new amide derivatives of 3,3-disubstituted pyrrolidine-2,5-...

    Call: OPUS 6 , Panel: NZ7

    Principal investigator: prof. Jolanta Maria Obniska

    Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

  7. Synthesis of pyridopyrimidine derivatives, dual affinity ligands for 5-HT1AR and SERT.

    Call: OPUS 6 , Panel: NZ7

    Principal investigator: prof. Franciszek Herold

    Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

  8. Synthesis and biological evaluation of pyrrolidine-2,5-dione derivatives as potential antidepressant agents.

    Call: OPUS 5 , Panel: NZ7

    Principal investigator: dr Andrzej Józef Chodkowski

    Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

  9. Synthesis and pharmacological characterization of novel cyclic opioid peptide analogs incorporating fluoro amino acids.

    Call: PRELUDIUM 5 , Panel: NZ7

    Principal investigator: dr Justyna Piekielna-Ciesielska

    Uniwersytet Medyczny w Łodzi, Wydział Lekarski

  10. Antidepressats as substances that increase the activity of risperidone, an atypical antipsychotic drug in animal models

    Call: PRELUDIUM 5 , Panel: NZ7

    Principal investigator: Katarzyna Karolina Kamińska

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  11. The role of chemokines in the pathogenesis of depression and molecular mechanism of action of antidepressants.

    Call: OPUS 5 , Panel: NZ7

    Principal investigator: prof. Agnieszka Basta-Kaim

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  12. The effect of imipramine and risperidone on regulation of the chronic mild stress-induced anhedonia and memory impairmen...

    Call: OPUS 5 , Panel: NZ7

    Principal investigator: Mariusz Papp

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  13. Transcription factor MeCP2 as an intracellular object of study on the mechanism of depression and as a potential pharmac...

    Call: SONATA 5 , Panel: NZ7

    Principal investigator: dr Magdalena Jolanta Sowa-Kućma

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  14. Obtaining of new quinoline derivatives with potential activity for serotonin receptors and inhibition of serotonin reupt...

    Call: PRELUDIUM 5 , Panel: NZ7

    Principal investigator: Przemysław Paweł Taciak

    Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

  15. Involvement of 5-HT1A receptor signal pathway in the antidepressant effect of zinc

    Call: HARMONIA 4 , Panel: NZ7

    Principal investigator: dr Bernadeta Szewczyk

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  16. Research on influence of antidepressant drugs on serum and brain levels of neurotrophins in rats, affected by the time d...

    Call: OPUS 4 , Panel: NZ4

    Principal investigator: dr Maciej Sławomir Kuśmider

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  17. Synthesis and pharmacological properties of mono- di- and triheterocyclic azole derivatives as a hybrid receptor and PDE...

    Call: OPUS 4 , Panel: NZ7

    Principal investigator: prof. Maciej Henryk Pawłowski

    Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

  18. Electrochemical detection of phycotropic substances based on DNA intercalation

    Call: PRELUDIUM 4 , Panel: ST4

    Principal investigator: dr Joanna Maria Jankowska-Śliwińska

    Instytut Biocybernetyki i Inżynierii Biomedycznej im. Macieja Nałęcza Polskiej Akademii Nauk

  19. The role of CRH-BP protein in the regulation of the hypothalamic-pituitary-adrenal axis after antidepressant drugs treat...

    Call: OPUS 3 , Panel: NZ4

    Principal investigator: dr Joanna Solich

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  20. Role of the endocannabionoid system in the pathogenesis of depression and in the mechanism of action of antidepressant d...

    Call: OPUS 3 , Panel: NZ7

    Principal investigator: prof. Małgorzata Maria Filip

    Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

  21. Evaluation of the role of subpopulations of T lymphocytes (Treg: CD4+CD25+, CD4+CD25- i Teff: Th2) in depression using p...

    Call: OPUS 3 , Panel: NZ4

    Principal investigator: dr Sylwia Kędracka-Krok

    Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

  22. LCAP biomimetics - alicyclic amine derivatives as a new class of monoaminergic receptor ligands

    Call: OPUS 3 , Panel: NZ7

    Principal investigator: dr hab. Paweł Maria Zajdel

    Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

  23. Modulation of 5-HT7 receptor signaling as common mechanism involved in the long-lasting antidepressant effects of typica...

    Call: SONATA 20 , Panel: NZ7

    Principal investigator: dr Barbara Wanda Chruścicka-Smaga

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  24. Mechanisms of Antidepressant Action of Psilocybin: The Role of 5-HT2B-5-HT1A Receptor Dimerization and GSK-3β Activation...

    Call: OPUS 27 , Panel: NZ7

    Principal investigator: dr hab. Agata Faron-Górecka

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  25. Dual Se-containing 5-HT1A and 5-HT7 biased agonists activating sigma-1 receptor as a hope of finding fast-acting antidep...

    Call: OPUS 27 , Panel: NZ7

    Principal investigator: prof. Karolina Anna Pytka

    Uniwersytet Jagielloński

  26. Anti-neuroinflammatory and antidepressant activities of mycelial in vitro cultures of selected edible mushrooms enriched...

    Call: PRELUDIUM 23 , Panel: NZ7

    Principal investigator: Jan Patryk Lazur

    Uniwersytet Jagielloński

  27. Evaluation of the relationship between doxorubicin resistance, epithelial-mesenchymal plasticity, and effects of selecte...

    Call: PRELUDIUM 23 , Panel: NZ5

    Principal investigator: Dominika Kunachowicz

    Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu

  28. Optogenetic and chemogenetic identification of brain circuits and cellular mechanisms underlying antidepressants resista...

    Call: OPUS 26 , Panel: NZ7

    Principal investigator: prof. Mariusz Papp

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  29. The cross-talk between 5-HTR2A and mGluR2 as a window for antidepressant effects of psilocybin.

    Call: OPUS 25 , Panel: NZ7

    Principal investigator: prof. Andrzej Mikołaj Pilc

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  30. The role of GPR39 receptor in the mechanism of antidepressant action

    Call: OPUS 2 , Panel: NZ7

    Principal investigator: dr Katarzyna Młyniec

    Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

  31. Enhancement of antidepressant therapy by combined administration of hyperforin and ketamine: behavioral and molecular st...

    Call: SONATA 17 , Panel: NZ7

    Principal investigator: dr Bartłomiej Pochwat

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  32. Translational and interdisciplinary investigation of phenotypes of reinforcement sensitivity as predictors of the respon...

    Call: OPUS 22 , Panel: HS6

    Principal investigator: dr hab. Rafał Ryguła

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  33. The role of the immune checkpoints in the pathomechanism of depressive disorders.

    Call: OPUS 22 , Panel: NZ6

    Principal investigator: prof. Marta Wanda Kubera

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  34. 3D printing as a tool to obtain transdermal microneedle systems with improved efficiency in the treatment of depressive ...

    Call: SONATA BIS 11 , Panel: NZ7

    Principal investigator: prof. Tomasz Zbigniew Osmałek

    Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Farmaceutyczny

  35. Metabolic stability and inhibition of P450 enzymes in combination with chemometric techniques as a tool for selection of...

    Call: OPUS 2 , Panel: NZ1

    Principal investigator: prof. Tomasz Bączek

    Gdański Uniwersytet Medyczny, Wydział Farmcautyczny z Oddziałem Medycyny Laboratoryjnej

  36. Impact of pharmacogenetic profiles on depression treatment outcomes

    Call: SONATINA 5 , Panel: NZ2

    Principal investigator: dr Małgorzata Maria Borczyk

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  37. Combined administration of muscarinic receptor antagonists and group II/III metabotropic glutamate (mGlu) receptor ligan...

    Call: OPUS 19 , Panel: NZ7

    Principal investigator: prof. Andrzej Mikołaj Pilc

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  38. Investigation of molecular mechanisms of rapid antidepressant action of NLX-101, a biased agonist of the 5-HT1A receptor...

    Call: OPUS 18 , Panel: NZ7

    Principal investigator: prof. Mariusz Papp

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  39. The influence of microplastics on the toxicity and fate of selected antidepressants

    Call: OPUS 18 , Panel: NZ8

    Principal investigator: prof. Grzegorz Leszek Nałęcz-Jawecki

    Warszawski Uniwersytet Medyczny

  40. Dual action of HBK-15 – unraveling cellular mechanisms underlying its fast antidepressant-like and procognitive effects...

    Call: SONATA BIS 9 , Panel: NZ7

    Principal investigator: dr hab. Karolina Anna Pytka

    Uniwersytet Jagielloński, Collegium Medicum

  41. Novel pharmacological strategies for the treatment of depression

    Call: OPUS 16 , Panel: NZ7

    Principal investigator: dr hab. Katarzyna Młyniec

    Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

  42. The role of selected metabotropic glutamate receptors in the mechanism of rapid antidepressant effect of RS-ketamine and...

    Call: OPUS 14 , Panel: NZ7

    Principal investigator: dr hab. Agnieszka Pałucha-Poniewiera

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  43. Anilide derivatives of long-chain cyclic amines as multifunctional serotonin receptors ligands and phosphodiesterase 7 i...

    Call: PRELUDIUM 13 , Panel: NZ7

    Principal investigator: dr Agnieszka Wioleta Jankowska

    Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

  44. Pharmacological and optogenetic investigation of the mechanism of action of Deep Brain Stimulation of the ventromedial p...

    Call: OPUS 13 , Panel: NZ7

    Principal investigator: prof. Mariusz Papp

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  45. Zinc Deficiency: An essential Variable for the Induction od Resistance to Antidepressants

    Call: PRELUDIUM 13 , Panel: NZ5

    Principal investigator: dr Anna Maria Rafało-Ulińska

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  46. Role of oxidative stress and ceramide in the pathogenesis of depression and in the mechanizm of action of antidepressant...

    Call: PRELUDIUM 12 , Panel: NZ5

    Principal investigator: Justyna Józefa Brodowicz

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  47. Evaluation of interactions of aripiprazole, the atypical amtipsychotic drug, with the selected antidepressants in the ra...

    Call: OPUS 12 , Panel: NZ7

    Principal investigator: dr hab. Zofia Maria Rogóż

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  48. Modeling of quantitative structure-metabolic stability relationships as a tool to improve design of potential novel anti...

    Call: OPUS 12 , Panel: NZ7

    Principal investigator: prof. Tomasz Bączek

    Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

  49. Effect of modulation of the GPR39 zinc receptor on glutamatergic and gabaergic transmission in the context of antidepres...

    Call: PRELUDIUM 11 , Panel: NZ7

    Principal investigator: Gabriela Joanna Starowicz

    Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

  50. The importance of interaction between NMDA and AMPA receptors and scaffolding proteins in the excitatory synaptic in the...

    Call: OPUS 11 , Panel: NZ7

    Principal investigator: dr hab. Magdalena Jolanta Sowa-Kućma

    Uniwersytet Rzeszowski, Kolegium Nauk Medycznych

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