Projects funded by the NCN

Selected antidepressants toxicity assessment based on in vitro studies of rat spermatocytes and mouse cell lines.

Call: PRELUDIUM 8 , Panel: NZ7

Principal investigator: Przemysław Sołek

Uniwersytet Rzeszowski, Wydział Biotechnologii

Molecular mechanism of action of antidepressant drugs in the in vitro model of contact allergy in the human cell line Ha...

Call: PRELUDIUM 7 , Panel: NZ6

Principal investigator: Katarzyna Curzytek

Instytut Farmakologii PAN

Involvement of cyclooxygenase 2 in antidepressant-like effects of metabotropic glutamatergic receptors group I.

Call: SONATA 7 , Panel: NZ7

Principal investigator: dr Katarzyna Stachowicz

Instytut Farmakologii PAN

Evaluation of the role of transcription factor CREB in the mechanisms antidepressant treatment: study on the novel genet...

Call: OPUS 7 , Panel: NZ7

Principal investigator: dr Grzegorz Kreiner

Instytut Farmakologii PAN

Research of mechanisms of antidepressant action of group II and III mGlu receptor ligands and their role in inducing rap...

Call: OPUS 7 , Panel: NZ7

Principal investigator: dr hab. Agnieszka Pałucha-Poniewiera

Instytut Farmakologii PAN

Synthesis, physicochemical and pharmacological properties of new amide derivatives of 3,3-disubstituted pyrrolidine-2,5-...

Call: OPUS 6 , Panel: NZ7

Principal investigator: prof. Jolanta Obniska

Uniwersytet Jagielloński Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

Synthesis of pyridopyrimidine derivatives, dual affinity ligands for 5-HT1AR and SERT.

Call: OPUS 6 , Panel: NZ7

Principal investigator: prof. Franciszek Herold

Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

Synthesis and biological evaluation of pyrrolidine-2,5-dione derivatives as potential antidepressant agents.

Call: OPUS 5 , Panel: NZ7

Principal investigator: dr Andrzej Chodkowski

Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

Synthesis and pharmacological characterization of novel cyclic opioid peptide analogs incorporating fluoro amino acids.

Call: PRELUDIUM 5 , Panel: NZ7

Principal investigator: dr Justyna Piekielna-Ciesielska

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Antidepressats as substances that increase the activity of risperidone, an atypical antipsychotic drug in animal models

Call: PRELUDIUM 5 , Panel: NZ7

Principal investigator: Katarzyna Kamińska

Instytut Farmakologii PAN

The role of chemokines in the pathogenesis of depression and molecular mechanism of action of antidepressants.

Call: OPUS 5 , Panel: NZ7

Principal investigator: prof. Agnieszka Basta-Kaim

Instytut Farmakologii PAN

The effect of imipramine and risperidone on regulation of the chronic mild stress-induced anhedonia and memory impairmen...

Call: OPUS 5 , Panel: NZ7

Principal investigator: dr hab. Mariusz Papp

Instytut Farmakologii PAN

Transcription factor MeCP2 as an intracellular object of study on the mechanism of depression and as a potential pharmac...

Call: SONATA 5 , Panel: NZ7

Principal investigator: dr Magdalena Sowa-Kućma

Instytut Farmakologii PAN

Obtaining of new quinoline derivatives with potential activity for serotonin receptors and inhibition of serotonin reupt...

Call: PRELUDIUM 5 , Panel: NZ7

Principal investigator: Przemysław Taciak

Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

Involvement of 5-HT1A receptor signal pathway in the antidepressant effect of zinc

Call: HARMONIA 4 , Panel: NZ7

Principal investigator: dr Bernadeta Szewczyk

Instytut Farmakologii PAN

Research on influence of antidepressant drugs on serum and brain levels of neurotrophins in rats, affected by the time d...

Call: OPUS 4 , Panel: NZ4

Principal investigator: dr Maciej Kuśmider

Instytut Farmakologii PAN

Synthesis and pharmacological properties of mono- di- and triheterocyclic azole derivatives as a hybrid receptor and PDE...

Call: OPUS 4 , Panel: NZ7

Principal investigator: prof. Maciej Pawłowski

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

Electrochemical detection of phycotropic substances based on DNA intercalation

Call: PRELUDIUM 4 , Panel: ST4

Principal investigator: dr Joanna Jankowska-Śliwińska

Instytut Biocybernetyki i Inżynierii Biomedycznej im. Macieja Nałęcza PAN

The role of CRH-BP protein in the regulation of the hypothalamic-pituitary-adrenal axis after antidepressant drugs treat...

Call: OPUS 3 , Panel: NZ4

Principal investigator: dr Joanna Solich

Instytut Farmakologii PAN

Role of the endocannabionoid system in the pathogenesis of depression and in the mechanism of action of antidepressant d...

Call: OPUS 3 , Panel: NZ7

Principal investigator: prof. Małgorzata Filip

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

Evaluation of the role of subpopulations of T lymphocytes (Treg: CD4+CD25+, CD4+CD25- i Teff: Th2) in depression using p...

Call: OPUS 3 , Panel: NZ4

Principal investigator: dr Sylwia Kędracka-Krok

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

LCAP biomimetics - alicyclic amine derivatives as a new class of monoaminergic receptor ligands

Call: OPUS 3 , Panel: NZ7

Principal investigator: dr hab. Paweł Zajdel

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

The cross-talk between 5-HTR2A and mGluR2 as a window for antidepressant effects of psilocybin.

Call: OPUS 25 , Panel: NZ7

Principal investigator: prof. Andrzej Pilc

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

The role of GPR39 receptor in the mechanism of antidepressant action

Call: OPUS 2 , Panel: NZ7

Principal investigator: dr Katarzyna Młyniec

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

Enhancement of antidepressant therapy by combined administration of hyperforin and ketamine: behavioral and molecular st...

Call: SONATA 17 , Panel: NZ7

Principal investigator: dr Bartłomiej Pochwat

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Translational and interdisciplinary investigation of phenotypes of reinforcement sensitivity as predictors of the respon...

Call: OPUS 22 , Panel: HS6

Principal investigator: dr hab. Rafał Ryguła

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

The role of the immune checkpoints in the pathomechanism of depressive disorders.

Call: OPUS 22 , Panel: NZ6

Principal investigator: prof. Marta Kubera

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

3D printing as a tool to obtain transdermal microneedle systems with improved efficiency in the treatment of depressive ...

Call: SONATA BIS 11 , Panel: NZ7

Principal investigator: dr hab. Tomasz Osmałek

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Farmaceutyczny

Metabolic stability and inhibition of P450 enzymes in combination with chemometric techniques as a tool for selection of...

Call: OPUS 2 , Panel: NZ1

Principal investigator: prof. Tomasz Bączek

Gdański Uniwersytet Medyczny, Wydział Farmcautyczny z Oddziałem Medycyny Laboratoryjnej

Impact of pharmacogenetic profiles on depression treatment outcomes

Call: SONATINA 5 , Panel: NZ2

Principal investigator: dr Małgorzata Borczyk

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Combined administration of muscarinic receptor antagonists and group II/III metabotropic glutamate (mGlu) receptor ligan...

Call: OPUS 19 , Panel: NZ7

Principal investigator: prof. Andrzej Pilc

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Investigation of molecular mechanisms of rapid antidepressant action of NLX-101, a biased agonist of the 5-HT1A receptor...

Call: OPUS 18 , Panel: NZ7

Principal investigator: prof. Mariusz Papp

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

The influence of microplastics on the toxicity and fate of selected antidepressants

Call: OPUS 18 , Panel: NZ8

Principal investigator: prof. Grzegorz Nałęcz-Jawecki

Warszawski Uniwersytet Medyczny

Dual action of HBK-15 – unraveling cellular mechanisms underlying its fast antidepressant-like and procognitive effects...

Call: SONATA BIS 9 , Panel: NZ7

Principal investigator: dr hab. Karolina Pytka

Uniwersytet Jagielloński, Collegium Medicum

Novel pharmacological strategies for the treatment of depression

Call: OPUS 16 , Panel: NZ7

Principal investigator: dr hab. Katarzyna Młyniec

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

The role of selected metabotropic glutamate receptors in the mechanism of rapid antidepressant effect of RS-ketamine and...

Call: OPUS 14 , Panel: NZ7

Principal investigator: dr hab. Agnieszka Pałucha-Poniewiera

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Anilide derivatives of long-chain cyclic amines as multifunctional serotonin receptors ligands and phosphodiesterase 7 i...

Call: PRELUDIUM 13 , Panel: NZ7

Principal investigator: dr Agnieszka Jankowska

Uniwersytet Jagielloński – Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

Pharmacological and optogenetic investigation of the mechanism of action of Deep Brain Stimulation of the ventromedial p...

Call: OPUS 13 , Panel: NZ7

Principal investigator: prof. Mariusz Papp

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Zinc Deficiency: An essential Variable for the Induction od Resistance to Antidepressants

Call: PRELUDIUM 13 , Panel: NZ5

Principal investigator: dr Anna Rafało-Ulińska

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Role of oxidative stress and ceramide in the pathogenesis of depression and in the mechanizm of action of antidepressant...

Call: PRELUDIUM 12 , Panel: NZ5

Principal investigator: Justyna Brodowicz

Instytut Farmakologii Polskiej Akademii Nauk

Evaluation of interactions of aripiprazole, the atypical amtipsychotic drug, with the selected antidepressants in the ra...

Call: OPUS 12 , Panel: NZ7

Principal investigator: dr hab. Zofia Rogóż

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Modeling of quantitative structure-metabolic stability relationships as a tool to improve design of potential novel anti...

Call: OPUS 12 , Panel: NZ7

Principal investigator: prof. Tomasz Bączek

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

Effect of modulation of the GPR39 zinc receptor on glutamatergic and gabaergic transmission in the context of antidepres...

Call: PRELUDIUM 11 , Panel: NZ7

Principal investigator: Gabriela Starowicz

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

The importance of interaction between NMDA and AMPA receptors and scaffolding proteins in the excitatory synaptic in the...

Call: OPUS 11 , Panel: NZ7

Principal investigator: dr Magdalena Sowa-Kućma

Instytut Farmakologii Polskiej Akademii Nauk

The effect of the metabotropic glutamatergic receptor ligands on potentiating the antidepressant-like actvity of scopola...

Call: PRELUDIUM 10 , Panel: NZ7

Principal investigator: Karolina Podkowa

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

The role of inflammation, oxidative and nitrosative stress, tryptophan catabolites pathway and DNA base excision repair ...

Call: OPUS 10 , Panel: NZ7

Principal investigator: dr hab. Tomasz Śliwiński

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Functional dissection of three alpha(1)-adrenergic receptor subtypes in the effects of antidepressant drugs: exploitatio...

Call: OPUS 9 , Panel: NZ7

Principal investigator: prof. Irena Nalepa

Instytut Farmakologii PAN

Investigation of the effects and mechanisms of action of Deep Brain Stimulation in two animal models of treatment-resist...

Call: OPUS 9 , Panel: NZ7

Principal investigator: prof. Mariusz Papp

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

The application of a modern chromatographic platform with biodetection: HPLC-DAD/MAO A/ESI-TOF-MS in the antidepressant ...

Call: SONATA 9 , Panel: NZ7

Principal investigator: dr hab. Wirginia Kukuła-Koch

Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny

Role of the NLRP3 inflammasome in the mechanisms of action of antidepressant drugs - study in an animal model of depress...

Call: PRELUDIUM 9 , Panel: NZ7

Principal investigator: dr Ewa Trojan

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk