Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Evaluation of interactions of aripiprazole, the atypical amtipsychotic drug, with the selected antidepressants in the rat models of schizophrenia. Behavioral and biochemical studies.

2016/23/B/NZ7/01280

Keywords:

schizophrenia glutation deficiency aripiprazole antidepressant drugs behavioral and biochemical tests rats

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_16: Other related subjects

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Zofia Rogóż 

Number of co-investigators in the project: 6

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 978 200 PLN

Project start date (Y-m-d): 2017-07-25

Project end date (Y-m-d): 2021-07-24

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Zestaw mikrodializacyjny RATURN, dwustanowiskowy dla szczurów i myszy (72 100 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (12)
  1. Glutathione deficiency and alterations in the sulfur amino acid homeostasis during early postnatal development as potential triggering factor for schizophrenia-like behavior in adult rats.
    Authors:
    Górny M, Wnuk A, Kamińska A, Kamińska K, Chwatko G, Bilska-Wilkosz A, Iciek M, Kajta M, Rogóż Z, Lorenc-Koci E.
    Academic press:
    Molecules (rok: 2019, tom: 24(23), 4253, strony: 45318), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules24234253 - link to the publication
  2. Glutathione deficiency during elary postnatal development caused schizophrenia-like symptoms and a reduction in DBNF levels in the cortex and hippocampus of adult Sprague-Dawley rats.
    Authors:
    Lech MA, Leśkiewicz M, Kamińska K, Rogóż , Lorenc-Koci E.
    Academic press:
    Int J Mol Science (rok: 2021, tom: 22, strony: -), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22126171 - link to the publication
  3. Repeated co-treatment with mirtazapine and aripiprazole reversed the schizophrenia-like behaviors and increased the BDNF mRNA expression in the adult Sprague-Dawley rats induced by gluthatione deficit during early postnatal brain development.
    Authors:
    Lech MA, Kamińska K, Wąsik A, Lorenc-Koci E, Rogóż Z.
    Academic press:
    J Physiol Pharmacol. (rok: 2021, tom: -, strony: -), Wydawca: Department of Physiology, Collegium Medicum Jagiellonian University
    Status:
    Submitted
    DOI:
    brak - link to the publication
  4. Effect of combined treatment with aripiprazole and antidepressants on the MK-801-induced deficits in recognition memory in novel recognition test and on the release of monoamines in the rat frontal cortex
    Authors:
    Hereta M, Kamińska K, Białoń M, Wąsik A, Lorenc-Koci E, Rogóż Z.
    Academic press:
    Behavioural Brain Research (rok: 2020, tom: 393, strony: 45302), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbr.2020.112769 - link to the publication
  5. Alterations in the Antioxidant Enzyme Activities in the Neurodevelopmental Rat Model of Schizophrenia Induced by Glutathione Deficiency during Early Postnatal Life
    Authors:
    Górny M, Bilska-Wilkosz A, Iciek M, Hereta M, Kamińska K, Kamińska A, Chwatko G, Rogóż Z, Lorenc-Koci E.
    Academic press:
    Antioxidants (rok: 2020, tom: 9, 538, strony: 45315), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/antiox9060538 - link to the publication
  6. Impact of repeated co-treatment with escitalopram and aripiprazole on the schizophrenia-like behaviors and BDNF mRNA expression in the adult Sprague-Dawley rats exposed to glutathione deficit during early postnatal development of the brain.
    Authors:
    Lech MA, Kamińska K, Leśkiewicz M, Lorenc-Koci E, Rogóż Z.
    Academic press:
    Pharmacol Rep. (rok: 2021, tom: -, strony: -), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s43440-021-00318-z - link to the publication
  1. Aripiprazole and antidepressants affect the BDNF mRNA expression and Akt signaling pathway in the neurodevelopment model of schizophrenia in rats.
    Authors:
    Lech MA, Leśkiewicz M, Lorenc-Koci E, Rogóż Z.
    Conference:
    4th Central European Biomedical Congress (CEBC). (rok: 2021, ), Wydawca: 4th Central European Biomedical Congress (CEBC).
    Data:
    konferencja 7-9.06
    Status:
    Published
  2. Alterations in antioxidant enzyme activities in the neurodevelopmental rat model of schizophrenia induced by glutathione deficiency during early postnatal life.
    Authors:
    Lorenc-Koci E, Górny M, Bilska-Wilkosz A, Iciek M, Hereta M, Kaminska K, Chwatko G, Rogóż Z.
    Conference:
    International Conference on Pharmaceutics and Drug Delivery systems" (rok: 2021, ), Wydawca: Phronesis Researchers World
    Data:
    konferencja 19-20.03
    Status:
    Published
  3. Antidepressant and aripiprazole reversed the MK-801-induced deficit in the recognition memory.
    Authors:
    Kamińska K, Lorenc-Koci E, Hereta M, Rogóż Z.
    Conference:
    3rd Central European Biomedical Congress, 15-18 September 2018, Kraków, Poland (rok: 2018, ), Wydawca: Programme
    Data:
    konferencja 15-18 September
    Status:
    Published
  4. Glutathione deficiency and alternations in the levels of sulfur-containing amino acids in rat tissues during early postnatal life as markers of schizophrenia-like behavior in adulthood.
    Authors:
    Lorenc-Koci E, Górny M, Kamińska A, Wnuk A, Kamińska K, Chwatko G, Kajta M, Rogóż Z.
    Conference:
    BIT's 9th Annual World Congress of Neurotalk-2018, May 16-18, 2018, Bangkok, Thailand (rok: 2018, ), Wydawca: BIT Congress Inc., China, Conference Abstract Book, p 139.
    Data:
    konferencja May 16-18
    Status:
    Published
  5. Glutathione deficit during brain development induces schizophrenia-like symptoms and decreases the brain-derived neurotrophic factor protein level in adult Sprague-Dawley rats
    Authors:
    Rogóż Z, Hereta M, Kamińska K, Leśkiewicz M, Trojan E, Lorenc-Koci E, Basta-Kaim A
    Conference:
    The 7th Mediterranean Neuroscience Society Conference, 23-27 June, 2019, Marrakech, Marocco (rok: 2019, ), Wydawca: Proceedingd of 7th Mediterranean Neuroscience Society Conference
    Data:
    konferencja 43639
    Status:
    Published
  6. Effect of co-treatment with aripiprazole and escitalopram in the perinatal glutathione model of schizophrenia.
    Authors:
    Hereta M, Rogóż Z
    Conference:
    20th International Congress of the Polish Pharmacological Society, 5-7 June, 2019, Lublin (rok: 2019, ), Wydawca: 20th International Congress of the Polish Pharmacological Society, Abstract book, p146
    Data:
    konferencja 43621
    Status:
    Published
  7. The effect of antidepressant on the aripiprazole-induced changes in the monoamines in the rat frontal cortex
    Authors:
    Hereta M, Kamińska K, Wąsik A, Rogóż Z
    Conference:
    The 7th Mediterranean Neuroscience Society Conference, 23-27 June, 2019, Marrakech, Marocco (rok: 2019, ), Wydawca: Proceedingd of 7th Mediterranean Neuroscience Society Conference
    Data:
    konferencja 43639
    Status:
    Published
  8. Alterations in the levels of sulfur-containing amino acids and global DNA methylation caused by glutathione deficit during early development as potential markers of schizophrenia-like behavior in adulthood.
    Authors:
    Lorenc-Koci E, Górny M, Kamińska A, Wnuk A, Kamińska K, XChwatko G, Kajta M, Rogóż Z
    Conference:
    The 7th Mediterranean Neuroscience Society Conference, 23-27 June, 2019, Marrakech, Marocco (rok: 2019, ), Wydawca: Proceedingd of 7th Mediterranean Neuroscience Society Conference
    Data:
    konferencja 43639
    Status:
    Published
  9. Co-treatment with aripiprazole and mirtazapine reversed the schizophrenia-like behavior in adult Sprague-Dawley rats induced by glutathione deficit during early postnatal brain development.
    Authors:
    Rogóż Z, Hereta M, Lorenc-Koci E.
    Conference:
    International Conference on Pharmaceutics and Drug Delivery systems" (rok: 2021, ), Wydawca: Phronesis Researchers World
    Data:
    konferencja 19-20.03
    Status:
    Published
  10. Effect of antidepressants and aripiprazole on the levels of monoamines in the rat frontal cortex.
    Authors:
    Rogóż Z, Hereta M, Kamińska K, Wąsik A.
    Conference:
    3rd Central European Biomedical Congress, 15-18 September 2018, Kraków, Poland (rok: 2018, ), Wydawca: Programme
    Data:
    konferencja 15-18 September
    Status:
    Published
  11. Glutathione deficit and alterations in the cysteine content during early postnatal life as potential factors initiating development of schizophrenia-like symptoms in adult rats
    Authors:
    Górny M, Kamińska A, Kamińska K, Chwatko G, Bilska-Wilkosz A, Rogóż Z, Lorenc-Koci E.
    Conference:
    The 44th FEBS Congress, 6-11 July, 2019, Kraków, Poland (rok: 2019, ), Wydawca: FEBS Open Bio 2019, 9 (suppl. 1)
    Data:
    konferencja 219-07-06
    Status:
    Published
  12. The effect of aripiprazole in adult Sprague-Dawley rats on the schizophrenia-like behavior induced by glutatione deficyt during early postnatal development.
    Authors:
    Rogóż Z, Kamińska K, Lorenc-Koci E.
    Conference:
    BIT's 9th Annual World Congress of Neurotalk-2018, May 16-18, 2018, Bangkok, Thailand (rok: 2018, ), Wydawca: BIT Congress Inc., China, Conference Abstract Book, p 140
    Data:
    konferencja May 16-18,
    Status:
    Published

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