Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Evaluation of interactions of aripiprazole, the atypical amtipsychotic drug, with the selected antidepressants in the rat models of schizophrenia. Behavioral and biochemical studies.

2016/23/B/NZ7/01280

Keywords:

schizophrenia glutation deficiency aripiprazole antidepressant drugs behavioral and biochemical tests rats

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_16: Other related subjects

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Zofia Rogóż 

Number of co-investigators in the project: 6

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 978 200 PLN

Project start date (Y-m-d): 2017-07-25

Project end date (Y-m-d): 2021-07-24

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Zestaw mikrodializacyjny RATURN, dwustanowiskowy dla szczurów i myszy (72 100 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (12)
  1. Alterations in the Antioxidant Enzyme Activities in the Neurodevelopmental Rat Model of Schizophrenia Induced by Glutathione Deficiency during Early Postnatal Life
    Authors:
    Górny M, Bilska-Wilkosz A, Iciek M, Hereta M, Kamińska K, Kamińska A, Chwatko G, Rogóż Z, Lorenc-Koci E.
    Academic press:
    Antioxidants (rok: 2020, tom: 9, 538, strony: 45315), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/antiox9060538 - link to the publication
  2. Effect of combined treatment with aripiprazole and antidepressants on the MK-801-induced deficits in recognition memory in novel recognition test and on the release of monoamines in the rat frontal cortex
    Authors:
    Hereta M, Kamińska K, Białoń M, Wąsik A, Lorenc-Koci E, Rogóż Z.
    Academic press:
    Behavioural Brain Research (rok: 2020, tom: 393, strony: 45302), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbr.2020.112769 - link to the publication
  3. Glutathione deficiency and alterations in the sulfur amino acid homeostasis during early postnatal development as potential triggering factor for schizophrenia-like behavior in adult rats.
    Authors:
    Górny M, Wnuk A, Kamińska A, Kamińska K, Chwatko G, Bilska-Wilkosz A, Iciek M, Kajta M, Rogóż Z, Lorenc-Koci E.
    Academic press:
    Molecules (rok: 2019, tom: 24(23), 4253, strony: 45318), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules24234253 - link to the publication
  4. Impact of repeated co-treatment with escitalopram and aripiprazole on the schizophrenia-like behaviors and BDNF mRNA expression in the adult Sprague-Dawley rats exposed to glutathione deficit during early postnatal development of the brain.
    Authors:
    Lech MA, Kamińska K, Leśkiewicz M, Lorenc-Koci E, Rogóż Z.
    Academic press:
    Pharmacol Rep. (rok: 2021, tom: -, strony: -), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s43440-021-00318-z - link to the publication
  5. Glutathione deficiency during elary postnatal development caused schizophrenia-like symptoms and a reduction in DBNF levels in the cortex and hippocampus of adult Sprague-Dawley rats.
    Authors:
    Lech MA, Leśkiewicz M, Kamińska K, Rogóż , Lorenc-Koci E.
    Academic press:
    Int J Mol Science (rok: 2021, tom: 22, strony: -), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22126171 - link to the publication
  6. Repeated co-treatment with mirtazapine and aripiprazole reversed the schizophrenia-like behaviors and increased the BDNF mRNA expression in the adult Sprague-Dawley rats induced by gluthatione deficit during early postnatal brain development.
    Authors:
    Lech MA, Kamińska K, Wąsik A, Lorenc-Koci E, Rogóż Z.
    Academic press:
    J Physiol Pharmacol. (rok: 2021, tom: -, strony: -), Wydawca: Department of Physiology, Collegium Medicum Jagiellonian University
    Status:
    Submitted
    DOI:
    brak - link to the publication
  1. Alterations in antioxidant enzyme activities in the neurodevelopmental rat model of schizophrenia induced by glutathione deficiency during early postnatal life.
    Authors:
    Lorenc-Koci E, Górny M, Bilska-Wilkosz A, Iciek M, Hereta M, Kaminska K, Chwatko G, Rogóż Z.
    Conference:
    International Conference on Pharmaceutics and Drug Delivery systems" (rok: 2021, ), Wydawca: Phronesis Researchers World
    Data:
    konferencja 19-20.03
    Status:
    Published
  2. Alterations in the levels of sulfur-containing amino acids and global DNA methylation caused by glutathione deficit during early development as potential markers of schizophrenia-like behavior in adulthood.
    Authors:
    Lorenc-Koci E, Górny M, Kamińska A, Wnuk A, Kamińska K, XChwatko G, Kajta M, Rogóż Z
    Conference:
    The 7th Mediterranean Neuroscience Society Conference, 23-27 June, 2019, Marrakech, Marocco (rok: 2019, ), Wydawca: Proceedingd of 7th Mediterranean Neuroscience Society Conference
    Data:
    konferencja 43639
    Status:
    Published
  3. The effect of antidepressant on the aripiprazole-induced changes in the monoamines in the rat frontal cortex
    Authors:
    Hereta M, Kamińska K, Wąsik A, Rogóż Z
    Conference:
    The 7th Mediterranean Neuroscience Society Conference, 23-27 June, 2019, Marrakech, Marocco (rok: 2019, ), Wydawca: Proceedingd of 7th Mediterranean Neuroscience Society Conference
    Data:
    konferencja 43639
    Status:
    Published
  4. Aripiprazole and antidepressants affect the BDNF mRNA expression and Akt signaling pathway in the neurodevelopment model of schizophrenia in rats.
    Authors:
    Lech MA, Leśkiewicz M, Lorenc-Koci E, Rogóż Z.
    Conference:
    4th Central European Biomedical Congress (CEBC). (rok: 2021, ), Wydawca: 4th Central European Biomedical Congress (CEBC).
    Data:
    konferencja 7-9.06
    Status:
    Published
  5. Effect of antidepressants and aripiprazole on the levels of monoamines in the rat frontal cortex.
    Authors:
    Rogóż Z, Hereta M, Kamińska K, Wąsik A.
    Conference:
    3rd Central European Biomedical Congress, 15-18 September 2018, Kraków, Poland (rok: 2018, ), Wydawca: Programme
    Data:
    konferencja 15-18 September
    Status:
    Published
  6. Effect of co-treatment with aripiprazole and escitalopram in the perinatal glutathione model of schizophrenia.
    Authors:
    Hereta M, Rogóż Z
    Conference:
    20th International Congress of the Polish Pharmacological Society, 5-7 June, 2019, Lublin (rok: 2019, ), Wydawca: 20th International Congress of the Polish Pharmacological Society, Abstract book, p146
    Data:
    konferencja 43621
    Status:
    Published
  7. Glutathione deficiency and alternations in the levels of sulfur-containing amino acids in rat tissues during early postnatal life as markers of schizophrenia-like behavior in adulthood.
    Authors:
    Lorenc-Koci E, Górny M, Kamińska A, Wnuk A, Kamińska K, Chwatko G, Kajta M, Rogóż Z.
    Conference:
    BIT's 9th Annual World Congress of Neurotalk-2018, May 16-18, 2018, Bangkok, Thailand (rok: 2018, ), Wydawca: BIT Congress Inc., China, Conference Abstract Book, p 139.
    Data:
    konferencja May 16-18
    Status:
    Published
  8. Glutathione deficit during brain development induces schizophrenia-like symptoms and decreases the brain-derived neurotrophic factor protein level in adult Sprague-Dawley rats
    Authors:
    Rogóż Z, Hereta M, Kamińska K, Leśkiewicz M, Trojan E, Lorenc-Koci E, Basta-Kaim A
    Conference:
    The 7th Mediterranean Neuroscience Society Conference, 23-27 June, 2019, Marrakech, Marocco (rok: 2019, ), Wydawca: Proceedingd of 7th Mediterranean Neuroscience Society Conference
    Data:
    konferencja 43639
    Status:
    Published
  9. Antidepressant and aripiprazole reversed the MK-801-induced deficit in the recognition memory.
    Authors:
    Kamińska K, Lorenc-Koci E, Hereta M, Rogóż Z.
    Conference:
    3rd Central European Biomedical Congress, 15-18 September 2018, Kraków, Poland (rok: 2018, ), Wydawca: Programme
    Data:
    konferencja 15-18 September
    Status:
    Published
  10. Glutathione deficit and alterations in the cysteine content during early postnatal life as potential factors initiating development of schizophrenia-like symptoms in adult rats
    Authors:
    Górny M, Kamińska A, Kamińska K, Chwatko G, Bilska-Wilkosz A, Rogóż Z, Lorenc-Koci E.
    Conference:
    The 44th FEBS Congress, 6-11 July, 2019, Kraków, Poland (rok: 2019, ), Wydawca: FEBS Open Bio 2019, 9 (suppl. 1)
    Data:
    konferencja 219-07-06
    Status:
    Published
  11. The effect of aripiprazole in adult Sprague-Dawley rats on the schizophrenia-like behavior induced by glutatione deficyt during early postnatal development.
    Authors:
    Rogóż Z, Kamińska K, Lorenc-Koci E.
    Conference:
    BIT's 9th Annual World Congress of Neurotalk-2018, May 16-18, 2018, Bangkok, Thailand (rok: 2018, ), Wydawca: BIT Congress Inc., China, Conference Abstract Book, p 140
    Data:
    konferencja May 16-18,
    Status:
    Published
  12. Co-treatment with aripiprazole and mirtazapine reversed the schizophrenia-like behavior in adult Sprague-Dawley rats induced by glutathione deficit during early postnatal brain development.
    Authors:
    Rogóż Z, Hereta M, Lorenc-Koci E.
    Conference:
    International Conference on Pharmaceutics and Drug Delivery systems" (rok: 2021, ), Wydawca: Phronesis Researchers World
    Data:
    konferencja 19-20.03
    Status:
    Published

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy