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Dual action of HBK-15 – unraveling cellular mechanisms underlying its fast antidepressant-like and procognitive effects

2019/34/E/NZ7/00454

Keywords

Descriptors

  • NZ7_014: Farmacja, farmakoterapia, farmakologia

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Uniwersytet Jagielloński, Collegium Medicum

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Karolina Anna Pytka

Number of co-investigators in the project: 6

Call

SONATA BIS 9 – announced on 2019-06-17

Amount awarded
3 169 300 PLN
Project start date
2020-04-14
Project end date
2026-04-13
Project duration
72 months (the same as in the proposal)
Project status
Project completed

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (8)

  1. MK-801 and cognitive functions: Investigating the behavioral effects of a non-competitive NMDA receptor antagonist

    Authors:
    Anna Janus, Klaudia Lustyk , Karolina Pytka
    Academic press:
    Psychopharmacology (Berl) (year: 2023, volume: 240, pages: 2435-2457), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s00213-023-06454-z – link to the publication

  2. Beyond the blur: Scopolamine's utility and limits in modeling cognitive disorders across sexes - Narrative review

    Authors:
    Jagielska Angelika, Sałaciak Kinga, Pytka Karolina
    Academic press:
    Ageing Research Reviews (year: 2024, volume: 104, pages: 102635), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.arr.2024.102635 – link to the publication

  3. Sex-dependent differences in animal cognition

    Authors:
    Aleksandra Koszałka , Klaudia Lustyk, Karolina Pytka
    Academic press:
    Neuroscience and Biobehavioral Reviews (year: 2023, volume: 153, pages: 105374), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neubiorev.2023.105374 – link to the publication

  4. Memory impairments in rodent depression models: A link with depression theories

    Authors:
    Kinga Sałaciak, Aleksandra Koszałka, Klaudia Lustyk, Elżbieta Żmudzka, Angelika Jagielska, Karolina Pytka
    Academic press:
    Prog Neuropsychopharmacol Biol Psychiatry (year: 2023, volume: 25, pages: 110774), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pnpbp.2023.110774 – link to the publication

  5. Biased agonism in drug discovery: Is there a future for biased 5-HT1A receptor agonists in the treatment of neuropsychiatric diseases?

    Authors:
    Sałaciak Kinga, Pytka Karolina
    Academic press:
    Pharmacology & Therapeutics (year: 2021, volume: 227, pages: 107872), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharmthera.2021.107872 – link to the publication

  6. HBK-15, a Multimodal Compound, Showed an Anxiolytic-Like Effect in Rats

    Authors:
    Klaudia Lustyk, Kinga Sałaciak, Magdalena Jakubczyk, Magdalena Jastrzębska-Więsek, Anna Partyka, Anna Wesołowska, Henryk Marona, Karolina Pytka
    Academic press:
    Neurochem Research (year: 2022, volume: 48, pages: 839-845), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s11064-022-03802-x – link to the publication

  7. The Calcium/Calmodulin-Dependent Kinases II and IV as Therapeutic Targets in Neurodegenerative and Neuropsychiatric Disorders

    Authors:
    Sałaciak Kinga, Koszałka Aleksandra, Żmudzka Elżbieta, Pytka Karolina
    Academic press:
    International Journal of Molecular Sciences (year: 2021, volume: 22, pages: 4307), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22094307. – link to the publication

  8. Revisiting the sigma-1 receptor as a biological target to treat affective and cognitive disorders

    Authors:
    Sałaciak Kinga, Pytka Karolina
    Academic press:
    Neuroscience & Biobehavioral Reviews (year: 2021, volume: 132, pages: 114-1136), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neubiorev.2021.10.037 – link to the publication

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