Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Dual action of HBK-15 – unraveling cellular mechanisms underlying its fast antidepressant-like and procognitive effects

2019/34/E/NZ7/00454

Keywords:

antidepressant-like activity procognitive effect depression memory impairments

Descriptors:

  • NZ7_014:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Jagielloński, Collegium Medicum

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Karolina Anna Pytka 

Number of co-investigators in the project: 6

Call: SONATA BIS 9 - announced on 2019-06-17

Amount awarded: 3 169 300 PLN

Project start date (Y-m-d): 2020-04-14

Project end date (Y-m-d): 2026-04-13

Project duration:: 72 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (9)
  1. Biased agonism in drug discovery: Is there a future for biased 5-HT1A receptor agonists in the treatment of neuropsychiatric diseases?
    Authors:
    Sałaciak Kinga, Pytka Karolina
    Academic press:
    Pharmacology & Therapeutics (rok: 2021, tom: 227, strony: 107872), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharmthera.2021.107872 - link to the publication
  2. Beyond the blur: Scopolamine's utility and limits in modeling cognitive disorders across sexes - Narrative review
    Authors:
    Jagielska Angelika, Sałaciak Kinga, Pytka Karolina
    Academic press:
    Ageing Research Reviews (rok: 2024, tom: 104, strony: 102635), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.arr.2024.102635 - link to the publication
  3. Beyond the blur: Scopolamine's utility and limits in modeling cognitive disorders across sexes - Narrative review
    Authors:
    Jagielska Angelika, Sałaciak Kinga, Pytka Karolina
    Academic press:
    Ageing Research Reviews (rok: 2024, tom: 104, strony: 102635), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.arr.2024.102635 - link to the publication
  4. MK-801 and cognitive functions: Investigating the behavioral effects of a non-competitive NMDA receptor antagonist
    Authors:
    Anna Janus, Klaudia Lustyk , Karolina Pytka
    Academic press:
    Psychopharmacology (Berl) (rok: 2023, tom: 240, strony: 2435-2457), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00213-023-06454-z - link to the publication
  5. Memory impairments in rodent depression models: A link with depression theories
    Authors:
    Kinga Sałaciak, Aleksandra Koszałka, Klaudia Lustyk, Elżbieta Żmudzka, Angelika Jagielska, Karolina Pytka
    Academic press:
    Prog Neuropsychopharmacol Biol Psychiatry (rok: 2023, tom: 25, strony: 110774), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pnpbp.2023.110774 - link to the publication
  6. The Calcium/Calmodulin-Dependent Kinases II and IV as Therapeutic Targets in Neurodegenerative and Neuropsychiatric Disorders
    Authors:
    Sałaciak Kinga, Koszałka Aleksandra, Żmudzka Elżbieta, Pytka Karolina
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 4307), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22094307. - link to the publication
  7. Sex-dependent differences in animal cognition
    Authors:
    Aleksandra Koszałka , Klaudia Lustyk, Karolina Pytka
    Academic press:
    Neuroscience and Biobehavioral Reviews (rok: 2023, tom: 153, strony: 105374), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neubiorev.2023.105374 - link to the publication
  8. Revisiting the sigma-1 receptor as a biological target to treat affective and cognitive disorders
    Authors:
    Sałaciak Kinga, Pytka Karolina
    Academic press:
    Neuroscience & Biobehavioral Reviews (rok: 2021, tom: 132, strony: 114-1136), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.037 - link to the publication
  9. HBK-15, a Multimodal Compound, Showed an Anxiolytic-Like Effect in Rats
    Authors:
    Klaudia Lustyk, Kinga Sałaciak, Magdalena Jakubczyk, Magdalena Jastrzębska-Więsek, Anna Partyka, Anna Wesołowska, Henryk Marona, Karolina Pytka
    Academic press:
    Neurochem Research (rok: 2022, tom: 48, strony: 839-845), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11064-022-03802-x - link to the publication

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