Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Research on influence of antidepressant drugs on serum and brain levels of neurotrophins in rats, affected by the time dependent sensitization mechanism.

2012/07/B/NZ4/01811

Keywords:

time dependent sensitization antidepressants neurotrophins

Descriptors:

  • NZ4_9: Systems neurobiology
  • NZ4_8: Neuroendocrinology
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Farmakologii PAN

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Maciej Kuśmider 

Number of co-investigators in the project: 5

Call: OPUS 4 - announced on 2012-09-15

Amount awarded: 734 120 PLN

Project start date (Y-m-d): 2013-07-15

Project end date (Y-m-d): 2017-07-14

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Autoklaw laboratoryjny.
  2. Wielokanałowa głowica pipetująca wraz z zestawem akcesoriów do stacji pipetującej EpMotion 5070.
  3. zestaw aparaturowy do badań z wykorzystaniem technologii Luminex (np.: Urzadzenie Luminex 200 z komputerem i oprogramowaniem xPonent 3.1 , Milliplex Analyst 5.1, MultiScreenHTS Vacuum Manifold, BioTek Magnetic 96 Well Plate Washer, 220 V complete with Schuko Power cords, Łaźnia ultradzwiękowa, Vortex-wytrząsarka do probówek Reax Top, Wytrząsarka do mikropłytek) (250 000 PLN)
  4. Homogenizator kulkowy z zestawem akcesoriów.

Information in the final report

  • Publication in academic press/journals (1)
  • Articles in post-conference publications (4)
  1. Effects of imipramine on cytokines panel in the rats serum during the drug treatment and discontinuation.
    Authors:
    M Kuśmider, A Faron-Górecka, P Pabian, J Solich, M Szlachta, M Kolasa, D Żurawek, J Wójcikowski, W Daniel, M Dziedzicka-Wasylewska
    Academic press:
    Neurochemistry International (rok: 2018, tom: 113, strony: 85-91), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuint.2017.11.016 - link to the publication
  1. Changes of rat brain expression of Calcyon, after chronic or acute imipramine treatment: evidence of time-dependent sensitization
    Authors:
    Maciej Kuśmider, Agata Faron-Górecka, Joanna Solich, Paulina Pabian, Dariusz Żurawek, Magdalena Kolasa, Marta Dziedzicka-Wasylewska
    Conference:
    Dopamine 2016 (rok: 2016, ), Wydawca: Austrian Pharmacological Society (APHAR)
    Data:
    konferencja 5-8 września 2016
    Status:
    Published
  2. Effect of imipramine on the peripheral th2/th1 cytokine production in the rat serum in the time-dependent sensitization paradigm
    Authors:
    A. FARON-GÓRECKA, M. KUŚMIDER, J. SOLICH, P. PABIAN, D. ZURAWEK, B. ZEMłA, M. DZIEDZICKA-WASYLEWSKA
    Conference:
    Neuroscience 2015 (rok: 2015, ), Wydawca: Society for Neuroscience
    Data:
    konferencja 17-21 października 2015
    Status:
    Published
  3. Imipramine affects circulating BDNF, prolactin and ACTH in time dependent manner
    Authors:
    M. KUŚMIDER, A. FARON-GÓRECKA, J. SOLICH, J. WÓJCIKOWSKI, D. ZURAWEK, P. PABIAN, W. DANIEL, M. DZIEDZICKA-WASYLEWSKA
    Conference:
    Neuroscience 2015 (rok: 2015, ), Wydawca: Society for Neuroscience
    Data:
    konferencja 17-21 października 2015
    Status:
    Published
  4. How imipramine treatment discontinuation affects serum neurotrophins concentration and brain interaction between BDNF and its receptors in rats.
    Authors:
    Kuśmider M, Faron-Górecka A, Szlachta M, Pabian P, Solich J, Kolasa M, Żurawek D, Dziedzicka-Wasylewska M
    Conference:
    Neurotrophic Factors (rok: 2017, ), Wydawca: Gordon Research Conferences
    Data:
    konferencja 4-9.06.2017
    Status:
    Published