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Involvement of 5-HT1A receptor signal pathway in the antidepressant effect of zinc

2013/08/M/NZ7/00518

Keywords:

zinc (Zn) depression 5-HT1A receptor second messengers

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ5_3: Pathogenesis of human diseases
  • NZ3_7: Signal transduction

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii PAN

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Bernadeta Szewczyk 

Number of co-investigators in the project: 7

Call: HARMONIA 4 - announced on 2012-12-15

Amount awarded: 646 490 PLN

Project start date (Y-m-d): 2013-09-09

Project end date (Y-m-d): 2017-07-08

Project duration:: 46 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (4)
  1. Involvement of extracellular signal-regulated kinase (ERK) in the short and long-lasting antidepressant-like activity of NMDA receptor antagonists (zinc and Ro 25–6981) in the forced swim test in rats
    Authors:
    Pochwat B, Rafało-Ulińska A, Misztak P, Domin H, Nowak G, Szewczyk B
    Academic press:
    Neuropharmacology (rok: 2017, tom: 125, strony: 333-342), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuropharm.2017.08.006 - link to the publication
  2. Concentration-Dependent Dual Mode of Zn Action at Serotonin 5-HT1A Receptors: In Vitro and In Vivo Studies
    Authors:
    Satała G, Duszyńska B, Stachowicz K, Rafalo A, Pochwat B, Luckhart C, Albert PR, Daigle M, Tanaka KF, Hen R, Lenda T, Nowak G, Bojarski AJ, Szewczyk B
    Academic press:
    Molecular Neurobiology (rok: 2015, tom: brak, strony: brak), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12035-015-9586-3 - link to the publication
  3. Activation of mTOR dependent signaling pathway is a necessary mechanism of antidepressant-like activity of zinc
    Authors:
    Bernadeta Szewczyk, Bartłomiej Pochwat, Anna Rafało, Agnieszka Palucha-Poniewiera, Helena Domin, Gabriel Nowak
    Academic press:
    Neuropharmacology (rok: 2015, tom: 99, strony: 517-526), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuropharm.2015.08.026 - link to the publication
  4. Antidepressant activity of zinc: Further evidence for the involvement of the serotonergic system
    Authors:
    Szewczyk B., Kotarska K., Siwek A., Olech Ł., Kuter K
    Academic press:
    Pharmacological Reports (rok: 2017, tom: 69, strony: 456-461), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharep.2017.01.008 - link to the publication
  1. Effects of zinc treatment on the 5-HT1A receptor function: behavioral responses
    Authors:
    Szewczyk B, Stachowicz K, Nowak G, Daigle M, Luckhart C, Cardin V, Hen R, Tanaka KF, Albert PR
    Conference:
    28th European College of Neuropsychopharmacology Congress (rok: 2015, ), Wydawca: European Neuropsychopharmacology
    Data:
    konferencja 29.08-01.09
    Status:
    Published
    DOI:
    link to the publication
  2. Antidepressant-like effect of zinc: further evidence for the involvement of serotonergic system
    Authors:
    Szewczyk B., Rafało A., Kotarska K., Siwek A., Nowak G
    Conference:
    10th FENS Forum of Neuroscience (rok: 2016, ), Wydawca: Programme Book
    Data:
    konferencja 2-6 lipiec
    Status:
    Published
    DOI:
    link to the publication
  3. Signaling pathways involved in the antidepressant-like effect of zinc
    Authors:
    Szewczyk B., Rafało A., Domin H., Nowak G
    Conference:
    2nd Central European Biomedical Congress (CEBC) "From emerging biochemical strategies to personalized medicine" (rok: 2016, ), Wydawca: Abstract Book
    Data:
    konferencja 15-18 czerwiec
    Status:
    Published
  4. Modulation of ERK1/2 signaling pathways is involved in antidepressant-like activity of zinc
    Authors:
    Szewczyk B, Misztak P, Rafało A, Sowa-Kućma M, Nowak G
    Conference:
    Neuroscience 2015 (rok: 2015, ), Wydawca: bd
    Data:
    konferencja 17-21 październik
    Status:
    Published
    DOI:
    link to the publication

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