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Evaluation of the role of transcription factor CREB in the mechanisms antidepressant treatment: study on the novel genetic models based on the Cre/loxP system.

2014/13/B/NZ7/02293

Keywords

Descriptors

  • NZ7_14: Farmacja, farmakoterapia, farmakologia
  • NZ3_7: Przekaźnictwo sygnału

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Instytut Farmakologii PAN

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Grzegorz Kreiner

Number of co-investigators in the project: 4

Call

OPUS 7 – announced on 2014-03-17

Amount awarded
673 100 PLN
Project start date
2015-01-27
Project end date
2019-01-26
Project duration
48 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Czytnik chemiluminescencji do analizy WesternBlot. Cost: 74 000 PLN
  2. Zautomatyzowany system klatek samowentylowanych do hodowli myszy transgenicznych. Cost: 70 000 PLN

Information in the final report

Publication in academic press/journals (3)

  1. Selective depletion of CREB in serotonergic neurons affects the upregulation of brain-derived neurotrophic factor evoked by chronic fluoxetine treatment

    Authors:
    Rafa-Zabłocka K, Kreiner G, Bagińska M, Nalepa I
    Academic press:
    Frontiers in Neuroscience (year: 2018, volume: 12 article 637, pages: 46036), Publisher: Frontiers In
    Status:
    Published
    DOI:
    10.3389/fnins.2018.00637. – link to the publication

  2. The influence of CaMKII and ERK phosphorylation on BDNF changes observed in mice selectively devoid of CREB in serotonergic or noradrenergic neurons

    Authors:
    Rafa-Zabłocka K, Kreiner G, Bagińska M, Nalepa I
    Academic press:
    Pharmacological Reports (year: 2019, volume: 71, pages: 753-761), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharep.2019.04.008 – link to the publication

  3. Transgenic mice lacking CREB and CREM in noradrenergic and serotonergic neurons respond differently to common antidepressants on tail suspension test

    Authors:
    Rafa-Zabłocka K, Kreiner G, Bagińska M, Kuśmierczyk J, Parlato R, Nalepa I
    Academic press:
    Scientific Reports (year: 2017, volume: 7(1):13515, pages: 7(1):13515), Publisher: NPG - Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-017-14069-6 – link to the publication

Articles in post-conference publications (6)

  1. Mice with selective ablation of cAMP response element-binding protein (CREB) in serotonergic neurons as a new tool for studying its role in antidepressant treatment

    Authors:
    Rafa-Zabłocka K, Bagińska M, Kreiner G, Nalepa I
    Conference:
    Chemical neuromodulation: neurobiological, neurocomputational, behavioral and clinical aspects (year: 2017, pages: 45-46), Publisher: FENS-SfN Summer School
    Date:
    conference 18-24.06
    Status:
    Published

  2. Evaluation of the role of transcription factor CREB in noradrenergic neurons in response to antidepressant treatment: study on novel transgenic mouse model

    Authors:
    Kreiner G, Rafa-Zabłocka K, Buczek W, Bagińska M
    Conference:
    46th Annual Meeting of Society for Neuroscience (SfN) - Neuroscience 2016 (year: 2016, pages: 1039-40), Publisher: Society for Neuroscience
    Date:
    conference 12-16.11
    Status:
    Published

  3. Evaluation of transgenic mice conditionally lacking CREB in noradrenergic neurons as a novel tool for studying its role in the antidepressant drug action

    Authors:
    Rafa-Zabłocka K, Kreiner G, Bagińska M, Nalepa I
    Conference:
    12-th International Congress of the Polish Neuroscience Society (year: 2015, pages: vol. 75, Supl1, S63-64), Publisher: Acta Neurobiologiae Experimentalis
    Date:
    conference 6-8.09.2015
    Status:
    Published

  4. CaMKII phosphorylation regulates the BDNF expression evoked by fluoxetine in hippocampus of mice

    Authors:
    Rafa-Zablocka K, Kreiner G, Baginska M, Nalepa I
    Conference:
    Central European Biomedical Congress (CEBC) (year: 2018, pages: Abstract Book, p. 47), Publisher: Instytut Farmakologii PAN
    Date:
    conference 15-18.09
    Status:
    Published

  5. Effects of selective depletion of CREB in serotonergic neurons on neurotrophin expression after fluoxetine treatment

    Authors:
    Rafa-Zabłocka K, Kreiner G, Bagińska M, Nalepa I
    Conference:
    48th Annual Meeting of Society for Neuroscience (SfN) - Neuroscience 2016 (year: 2018, pages: 323.26 2018 Neuroscience Meeting Planner), Publisher: Society for Neuroscience
    Date:
    conference 3-7.11
    Status:
    Published

  6. On the role of CREB and CREM in the mechanism of antidepressant drugs: study in the model of CREB deficient mice in serotonergic neurons

    Authors:
    Rafa-Zabłocka K, Kreiner G, Bagińska M, Nalepa I
    Conference:
    Interdisciplinary Junior Scientists Workshop on Neuropharmacology and Molecular Biology (year: 2017, pages: 30), Publisher: Institute of Pharmacology PAS
    Date:
    conference 29.03-01.04
    Status:
    Published

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Graphic design and implementation: Jakub Piotrowski