Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Evaluation of the role of transcription factor CREB in the mechanisms antidepressant treatment: study on the novel genetic models based on the Cre/loxP system.

2014/13/B/NZ7/02293

Keywords:

creb depression antidepressants noradrenergic system serotonergic system Cre/loxP system

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ3_7: Signal transduction

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii PAN

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Grzegorz Kreiner 

Number of co-investigators in the project: 4

Call: OPUS 7 - announced on 2014-03-17

Amount awarded: 673 100 PLN

Project start date (Y-m-d): 2015-01-27

Project end date (Y-m-d): 2019-01-26

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Zautomatyzowany system klatek samowentylowanych do hodowli myszy transgenicznych (70 000 PLN)
  2. Czytnik chemiluminescencji do analizy WesternBlot (74 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (6)
  1. Selective depletion of CREB in serotonergic neurons affects the upregulation of brain-derived neurotrophic factor evoked by chronic fluoxetine treatment
    Authors:
    Rafa-Zabłocka K, Kreiner G, Bagińska M, Nalepa I
    Academic press:
    Frontiers in Neuroscience (rok: 2018, tom: 12 article 637, strony: 45305), Wydawca: Frontiers In
    Status:
    Published
    DOI:
    10.3389/fnins.2018.00637. - link to the publication
  2. Transgenic mice lacking CREB and CREM in noradrenergic and serotonergic neurons respond differently to common antidepressants on tail suspension test
    Authors:
    Rafa-Zabłocka K, Kreiner G, Bagińska M, Kuśmierczyk J, Parlato R, Nalepa I
    Academic press:
    Scientific Reports (rok: 2017, tom: 7(1):13515, strony: 7(1):13515), Wydawca: NPG - Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-017-14069-6 - link to the publication
  3. The influence of CaMKII and ERK phosphorylation on BDNF changes observed in mice selectively devoid of CREB in serotonergic or noradrenergic neurons
    Authors:
    Rafa-Zabłocka K, Kreiner G, Bagińska M, Nalepa I
    Academic press:
    Pharmacological Reports (rok: 2019, tom: 71, strony: 753-761), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharep.2019.04.008 - link to the publication
  1. Evaluation of the role of transcription factor CREB in noradrenergic neurons in response to antidepressant treatment: study on novel transgenic mouse model
    Authors:
    Kreiner G, Rafa-Zabłocka K, Buczek W, Bagińska M
    Conference:
    46th Annual Meeting of Society for Neuroscience (SfN) - Neuroscience 2016 (rok: 2016, ), Wydawca: Society for Neuroscience
    Data:
    konferencja 12-16.11
    Status:
    Published
    DOI:
    link to the publication
  2. Mice with selective ablation of cAMP response element-binding protein (CREB) in serotonergic neurons as a new tool for studying its role in antidepressant treatment
    Authors:
    Rafa-Zabłocka K, Bagińska M, Kreiner G, Nalepa I
    Conference:
    Chemical neuromodulation: neurobiological, neurocomputational, behavioral and clinical aspects (rok: 2017, ), Wydawca: FENS-SfN Summer School
    Data:
    konferencja 18-24.06
    Status:
    Published
  3. Evaluation of transgenic mice conditionally lacking CREB in noradrenergic neurons as a novel tool for studying its role in the antidepressant drug action
    Authors:
    Rafa-Zabłocka K, Kreiner G, Bagińska M, Nalepa I
    Conference:
    12-th International Congress of the Polish Neuroscience Society (rok: 2015, ), Wydawca: Acta Neurobiologiae Experimentalis
    Data:
    konferencja 6-8.09.2015
    Status:
    Published
  4. CaMKII phosphorylation regulates the BDNF expression evoked by fluoxetine in hippocampus of mice
    Authors:
    Rafa-Zablocka K, Kreiner G, Baginska M, Nalepa I
    Conference:
    Central European Biomedical Congress (CEBC) (rok: 2018, ), Wydawca: Instytut Farmakologii PAN
    Data:
    konferencja 15-18.09
    Status:
    Published
    DOI:
    link to the publication
  5. On the role of CREB and CREM in the mechanism of antidepressant drugs: study in the model of CREB deficient mice in serotonergic neurons
    Authors:
    Rafa-Zabłocka K, Kreiner G, Bagińska M, Nalepa I
    Conference:
    Interdisciplinary Junior Scientists Workshop on Neuropharmacology and Molecular Biology (rok: 2017, ), Wydawca: Institute of Pharmacology PAS
    Data:
    konferencja 29.03-01.04
    Status:
    Published
    DOI:
    link to the publication
  6. Effects of selective depletion of CREB in serotonergic neurons on neurotrophin expression after fluoxetine treatment
    Authors:
    Rafa-Zabłocka K, Kreiner G, Bagińska M, Nalepa I
    Conference:
    48th Annual Meeting of Society for Neuroscience (SfN) - Neuroscience 2016 (rok: 2018, ), Wydawca: Society for Neuroscience
    Data:
    konferencja 3-7.11
    Status:
    Published

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