Projects funded by the NCN
Synthesis and biological evaluation of pyrrolidine-2,5-dione derivatives as potential antidepressant agents.
2013/09/B/NZ7/00748
Keywords:
depression serotonin receptor pirrolidine-2,5-dione indole serotonin transporter protein SERT
Descriptors:
- NZ7_14: Pharmacy, pharmacotherapy, pharmacology
Panel:
NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution :
Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej
woj. mazowieckie
Principal investigator (from the host institution):
Number of co-investigators in the project: 5
Call: OPUS 5 - announced on 2013-03-15
Amount awarded: 450 000 PLN
Project start date (Y-m-d): 2014-03-21
Project end date (Y-m-d): 2017-03-20
Project duration:: 36 months (the same as in the proposal)
Project status: Project settled
Equipment purchased [PL]
- Mnova Suite (NMR/Mnova NMRPredict Desktop/MS) Academic Nominated Annual Single licence Qty 5 (4 538 PLN)
Information in the final report
- Publication in academic press/journals (3)
- LIGANDY RECEPTORA 5-HT1A JAKO POTENCJALNE LEKI PRZECIWDEPRESYJNEAuthors:Martyna Z. Wróbel, Monika MarciniakAcademic press:BIULETYN Wydziału Farmaceutycznego Warszawskiego Uniwersytetu Medycznego (rok: 2015, tom: 5, strony: 28-39), Wydawca: Wydział Farmaceutyczny Warszawskiego Uniwersytetu MedycznegoStatus:PublishedDOI:"brak" - link to the publication
- Synthesis and biological evaluation of new multi-target 3-(1H-indol- 3-yl)pyrrolidine-2,5-dione derivatives with potential antidepressant effectAuthors:Martyna Z. Wróbel, Andrzej Chodkowski, Franciszek Herold, Monika Marciniak, Maciej Dawidowski, Agata Siwek, Gabriela Starowicz, Katarzyna Stachowicz, Bernadeta Szewczyk, Gabriel Nowak, Mariusz Belka, Tomasz Baczek, Grzegorz Satała, Andrzej J. Bojarski, Jadwiga TurłoAcademic press:European Journal of Medicinal Chemistry (rok: 2019, tom: 183, strony: 111736), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.ejmech.2019.111736 - link to the publication
- Synthesis of new 4-butyl-arylpiperazine-3-(1H-indol-3-yl)pyrrolidine-2,5-dione derivatives and their evaluation for 5-HT1A and D2 receptor affinity and serotonin transporter inhibitionAuthors:Martyna Z. Wróbel, Andrzej Chodkowski, Monika Marciniak, Maciej Dawidowski, Anna Maksymiuk, Agata Siwek, Gabriel Nowak, Jadwiga TurłoAcademic press:Bioorganic Chemistry (rok: 2020, ), Wydawca: ElsevierStatus:Accepted for publicationDOI:10.1016/j.bioorg.2020.103662 - link to the publication