Synthesis and biological evaluation of pyrrolidine-2,5-dione derivatives as pote

Synthesis and biological evaluation of pyrrolidine-2,5-dione derivatives as potential antidepressant agents.

2013/09/B/NZ7/00748

Keywords

Descriptors

NZ7_14: Farmacja, farmakoterapia, farmakologia

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Andrzej Józef Chodkowski

Number of co-investigators in the project: 5

Call

OPUS 5 – announced on 2013-03-15

Amount awarded: 450 000 PLN
Project start date: 2014-03-21
Project end date: 2017-03-20
Project duration: 36 months (the same as in the proposal)
Project status: Project settled

Equipment purchased [PL]

Mnova Suite (NMR/Mnova NMRPredict Desktop/MS) Academic Nominated Annual Single licence Qty 5. Cost: 4 538 PLN

Information in the final report

Publication in academic press/journals (3)

LIGANDY RECEPTORA 5-HT1A JAKO POTENCJALNE LEKI PRZECIWDEPRESYJNE

Authors:
Martyna Z. Wróbel, Monika Marciniak

Academic press:
BIULETYN Wydziału Farmaceutycznego Warszawskiego Uniwersytetu Medycznego (year: 2015, volume: 5, pages: 28-39), Publisher: Wydział Farmaceutyczny Warszawskiego Uniwersytetu Medycznego

Status:
Published

DOI:
link to the publication
Synthesis and biological evaluation of new multi-target 3-(1H-indol- 3-yl)pyrrolidine-2,5-dione derivatives with potential antidepressant effect

Authors:
Martyna Z. Wróbel, Andrzej Chodkowski, Franciszek Herold, Monika Marciniak, Maciej Dawidowski, Agata Siwek, Gabriela Starowicz, Katarzyna Stachowicz, Bernadeta Szewczyk, Gabriel Nowak, Mariusz Belka, Tomasz Baczek, Grzegorz Satała, Andrzej J. Bojarski, Jadwiga Turło

Academic press:
European Journal of Medicinal Chemistry (year: 2019, volume: 183, pages: 111736), Publisher: Elsevier

Status:
Published

DOI:
10.1016/j.ejmech.2019.111736 – link to the publication
Synthesis of new 4-butyl-arylpiperazine-3-(1H-indol-3-yl)pyrrolidine-2,5-dione derivatives and their evaluation for 5-HT1A and D2 receptor affinity and serotonin transporter inhibition

Authors:
Martyna Z. Wróbel, Andrzej Chodkowski, Monika Marciniak, Maciej Dawidowski, Anna Maksymiuk, Agata Siwek, Gabriel Nowak, Jadwiga Turło

Status:
Accepted for publication

« New search

Projects search