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The role of inflammation, oxidative and nitrosative stress, tryptophan catabolites pathway and DNA base excision repair in depressive disorder and in acting mechanism of antidepressant drugs in preclinical and clinical in vitro and in vivo studies.

2015/19/B/NZ7/00410

Keywords:

inflammation oxidative and nitrosative stress tryptophan catabolites pathway DNA base excision repair antidepressant drugs depressive disorder

Descriptors:

  • NZ7_12: Prevention of human diseases
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Tomasz Śliwiński 

Number of co-investigators in the project: 10

Call: OPUS 10 - announced on 2015-09-15

Amount awarded: 987 360 PLN

Project start date (Y-m-d): 2016-07-08

Project end date (Y-m-d): 2020-01-07

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (16)
  1. Preliminary Study of the Impact of Single-Nucleotide Polymorphisms of IL-1α, IL-1β and TNF-α Genes on the Occurrence, Severity and Treatment Effectiveness of the Major Depressive Disorder
    Authors:
    Bialek K, Czarny P, Watala C, Synowiec E, Wigner P, Bijak M, Talarowska M, Galecki P, Szemraj J, Sliwinski T
    Academic press:
    Cellular and Molecular Neurobiology (rok: 2020, tom: x, strony: x), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s10571-019-00782-5 - link to the publication
  2. Oxidative and Nitrosative Stress as Well as the Tryptophan Catabolites Pathway in Depressive Disorders.
    Authors:
    Wigner P, Czarny P, Galecki P, Sliwinski T.
    Academic press:
    Psychiatr Danub (rok: 2017, tom: 29, strony: 394-400), Wydawca: Medicinska naklada - Zagreb, Croatia
    Status:
    Published
    DOI:
    10.24869/psyd.2017.394. - link to the publication
  3. The Effect of Chronic Mild Stress and Venlafaxine on the Expression and Methylation Levels of Genes Involved in the Tryptophan Catabolites Pathway in the Blood and Brain Structures of Rats
    Authors:
    Paulina Wigner, Ewelina Synowiec, Paweł Jóźwiak, Piotr Czarny, Michal Bijak, Gabriela Barszczewska, Katarzyna Białek, Janusz Szemraj, Piotr Gruca, Mariusz Papp, Tomasz Śliwiński
    Academic press:
    Journal of Molecular Neuroscience (rok: 2020, tom: 70, strony: 1425–1436), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12031-020-01563-2 - link to the publication
  4. The Impact of Chronic Mild Stress and Agomelatine Treatment on the Expression Level and Methylation Status of Genes Involved in Tryptophan Catabolic Pathway in PBMCs and Brain Structures
    Authors:
    Wigner P, Synowiec E, Jóźwiak P, Czarny P, Białek K, Bijak M, Szemraj J, Gruca P, Papp M, Śliwiński T
    Academic press:
    Genes (rok: 2020, tom: 11, strony: 1093), Wydawca: Mdpi
    Status:
    Published
    DOI:
    10.3390/genes11091093 - link to the publication
  5. The effect of chronic mild stress and escitalopram on the expression and methylation levels of genes involved in the oxidative and nitrosative stresses as well as tryptophan catabolites pathway in the blood and brain structures
    Authors:
    Wigner P, Synowiec E, Jóźwiak P, Czarny P, Bijak M, Białek K, Szemraj J, Gruca P, Papp M, Śliwiński T
    Academic press:
    Int. J. Mol. Sc (rok: 2020, tom: 22, strony: 10), Wydawca: Mdpi
    Status:
    Published
    DOI:
    10.3390/ijms22010010 - link to the publication
  6. Chronic mild stress and venlafaxine treatment were associated with altered expression level and methylation status of new candidate inflammatory genes in PBMCs and Brain Structures of Wistar Rats
    Authors:
    Białek K, Czarny P, Wigner P, Synowiec E, Barszczewska G, Bijak M, Niemczyk M, Tota-Glowczyk K, Szemraj J, Papp M, Śliwiński T
    Academic press:
    Genes (rok: 2021, tom: 12, strony: 667), Wydawca: Mdpi
    Status:
    Published
    DOI:
    10.3390/genes12050667 - link to the publication
  7. DNA damage and repair in neuropsychiatric disorders. What do we know and what are the future perspectives?
    Authors:
    Czarny P, Bialek K, Ziolkowska S, Strycharz J, Sliwinski T.
    Academic press:
    Mutagenesis (rok: 2019, tom: 35, strony: 79-105), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/mutage/gez035 - link to the publication
  8. Effects of venlafaxine on the expression level and methylation status of genes involved in oxidative stress in rats exposed to a chronic mild stress
    Authors:
    Wigner P, Synowiec E, Czarny P, Bijak M, Jozwiak P, Szemraj J, Gruca P, Papp M, Sliwinski T
    Academic press:
    Journal of Cellular and Molecular Medicine (rok: 2020, tom: 24, strony: 5675-5694), Wydawca: Willey
    Status:
    Published
    DOI:
    10.1111/jcmm.15231 - link to the publication
  9. The molecular aspects of oxidative & nitrosative stress and the tryptophan catabolites pathway (TRYCATs) as potential causes of depression.
    Authors:
    Wigner P, Czarny P, Galecki P, Su KP, Sliwinski T
    Academic press:
    Psychiatry Res (rok: 2018, tom: 262, strony: 566-574), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.psychres.2017.09.045 - link to the publication
  10. Variation of genes encoding KAT1, AADAT and IDO1 as a potential risk of depression development
    Authors:
    Wigner P, Czarny P, Synowiec E, Bijak M, Talarowska M, Galecki P, Szemraj J, Sliwinski T
    Academic press:
    European Psychiatry (rok: 2018, tom: 52C, strony: 95-103), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.eurpsy.2018.05.001 - link to the publication
  11. The interplay between inflammation, oxidative stress, DNA damage, DNA repair and mitochondrial dysfunction in depression.
    Authors:
    Czarny P, Wigner P, Galecki P, Sliwinski T
    Academic press:
    Prog Neuropsychopharmacol Biol Psychiatry (rok: 2018, tom: 80, strony: 309-321), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pnpbp.2017.06.036 - link to the publication
  12. Association between single nucleotide polymorphisms of TPH1 and TPH2 genes, and depressive disorders
    Authors:
    Wigner P, Czarny P, Synowiec E, Bijak M, Białek K, Talarowska M, Galecki P, Szemraj J, Sliwinski T
    Academic press:
    Journal of Cellular and Molecular Medicine (rok: 2018, tom: 22, strony: 1778-1791), Wydawca: John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine
    Status:
    Published
    DOI:
    10.1111/jcmm.13459 - link to the publication
  13. Major depressive disorders accompanying autoimmune diseases - Response to treatment
    Authors:
    Bialek K, Czarny P, Strycharz J, Sliwinski T
    Academic press:
    Progress in Neuropsychopharmacology & Biological Psychiatry (rok: 2019, tom: 95, strony: 109678), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pnpbp.2019.109678 - link to the publication
  14. Novel association between TGFA, TGFB1, IRF1, PTGS2 and IKBKB single-nucleotide polymorphisms and occurrence, severity and treatment response of major depressive disorder
    Authors:
    Bialek K, Czarny P, Watala C, Wigner P, Talarowska M, Galecki P, Szemraj J, Sliwinski T
    Academic press:
    PeerJ (rok: 2020, tom: x, strony: x), Wydawca: PeerJ
    Status:
    Published
    DOI:
    10.7717/peerj.8676 - link to the publication
  15. The Changes of Expression and Methylation of Genes Involved in Oxidative Stress in Course of Chronic Mild Stress and Antidepressant Therapy with Agomelatine
    Authors:
    Paulina Wigner, Ewelina Synowiec, Paweł Jóźwiak, Piotr Czarny, Michał Bijak, Gabriela Barszczewska,Katarzyna Białek, Janusz Szemraj, Piotr Gruca, Mariusz Papp, Tomasz Śliwiński
    Academic press:
    Genes (rok: 2020, tom: 11, strony: 644), Wydawca: Mdpi
    Status:
    Published
    DOI:
    10.3390/genes11060644 - link to the publication
  16. Variation of genes involved in oxidative and nitrosative stresses in depression.
    Authors:
    Wigner P, Czarny P, Synowiec E, Bijak M, Białek K, Talarowska M, Galecki P, Szemraj J, Sliwinski T.
    Academic press:
    Eur Psychiatry (rok: 2018, tom: 48, strony: 38-48), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.012 - link to the publication

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