Combined administration of muscarinic receptor antagonists and group II/III metabotropic glutamate (mGlu) receptor ligands as a novel efficacious method to treat depression - the preclinical studies
2020/37/B/NZ7/03499
Keywords
Descriptors
- NZ7_014: Farmacja, farmakoterapia, farmakologia
- NZ5_007: Leczenie chorób człowieka
Panel
NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution
Instytut Farmakologii PAN
Voivodeship: małopolskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 6
Call
OPUS 19 – announced on 2020-03-16
- Amount awarded
- 2 980 248 PLN
- Project start date
- 2021-01-14
- Project end date
- 2026-01-13
- Project duration
- 60 months (the same as in the proposal)
- Project status
- Project completed
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
Publication in academic press/journals (4)
-
Where do we go next in antidepressant drug discovery? A new generation of antidepressants: a pivotal role of AMPA receptor potentiation and mGlu2/3 receptor antagonism
- Authors:
- Pilc, A., Machaczka, A., Kawalec, P., Smith, J.L., Witkin, J.M.
- Academic press:
- Expert Opinion on Drug Discovery (year: 2022, volume: 17-10, pages: 1131-1146), Publisher: Taylor&Francis
- Status:
- Published
- DOI:
- 10.1080/17460441.2022.2111415 – link to the publication
-
The Potential of Scopolamine as an Antidepressant in Major Depressive Disorder: A Systematic Review of Randomized Controlled Trials
- Authors:
- Paweł Mocko, Katarzyna ´ Sladowska, Paweł Kawalec, Yana Babii and Andrzej Pilc
- Academic press:
- Biomedicines (year: 2023, volume: 11, pages: 46034), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/biomedicines11102636 – link to the publication
-
Interaction of hallucinogenic rapid‑acting antidepressants with mGlu2/3 receptor ligands as a window for more effective therapies
- Authors:
- Barbara Chruścicka‑Smaga, · Agata Machaczka, · Bernadeta Szewczyk, · Andrzej Pilc
- Academic press:
- Pharmacological Reports (year: 2023, volume: 75/6, pages: 1341-1349), Publisher: Springer
- Status:
- Published
- DOI:
- 10.1007/s43440-023-00547-4 – link to the publication
-
Subchronic administration of scopolamine reverses UCMS-induced behavior in mice via eEF2 protein dephosphorylation
- Authors:
- Yana Babii, · Agnieszka Pałucha-Poniewiera, · Anna Rafało-Ulińska · Piotr Brański, · Andrzej Pilc
- Academic press:
- Pharmacological Reports (year: 2024, volume: 76/5, pages: 1001-1011), Publisher: Springer
- Status:
- Published
- DOI:
- 10.1007/s43440-024-00630-4 – link to the publication