Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The application of a modern chromatographic platform with biodetection: HPLC-DAD/MAO A/ESI-TOF-MS in the antidepressant activity screening of natural products

2015/17/D/NZ7/00822

Keywords:

hyphenated chromatographic techniques with HR-MS and biodetection HPLC/DAD/MAO A/ESI-TOF-MS monoamineoxydase A antidepressants 1D and 2D NMR Curcuma longa Zingiber officinale natural products

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_12: Prevention of human diseases
  • ST4_6: Instrumental methods in chemistry

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny

woj. lubelskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Wirginia Kukuła-Koch 

Number of co-investigators in the project: 3

Call: SONATA 9 - announced on 2015-03-16

Amount awarded: 336 600 PLN

Project start date (Y-m-d): 2016-03-17

Project end date (Y-m-d): 2020-03-16

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Postkolumnowy bioreaktor (89 000 PLN)
  2. Luminometr - czytnik mikropłytek do pomiaru luminescencji i fluorescencji.
  3. Wytrząsarka (10 000 PLN)

Information in the final report

  • Publication in academic press/journals (9)
  1. Acetylcholinesterase Inhibitors among Zingiber officinale Terpenes-Extraction Conditions and Thin Layer Chromatography-Based Bioautography Studies.
    Authors:
    LIDIA CZERNICKA, AGNIESZKA LUDWICZUK, EDWARD RÓJ, ZBIGNIEW MARZEC, AGATA JARZĄB, WIRGINIA KUKULA-KOCH*
    Academic press:
    Molecules (rok: 2020, tom: 25 (7), strony: [art. nr] 1643, s. 1-14), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25071643 - link to the publication
  2. Antimicrobial potential of single metabolites of Curcuma longa assessed in the total extract by thin-layer chromatography-based bioautography and image analysis
    Authors:
    Lidia Czernicka, Agnieszka Grzegorczyk, Zbigniew Marzec, Beata Antosiewicz, Anna Malm, Wirginia Kukula-Koch
    Academic press:
    International Journal of Molecular Sciences (rok: 2019, tom: 20, strony: 45303), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20040898 - link to the publication
  3. Recent advances in obesity: the role of turmeric tuber and its metabolites in the prophylaxis and therapeutical strategies
    Authors:
    Agata Jarząb, Wirginia Kukuła-Koch
    Academic press:
    Current Medicinal Chemistry (rok: 2018, tom: 25, strony: 4837-4853), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/0929867324666161118095443 - link to the publication
  4. 6‐gingerol, a major constituent of Zingiber officinale rhizoma, exerts anticonvulsant activity in the pentylenetetrazole‐ induced seizure model in larval zebrafish
    Authors:
    KINGA GAWEŁ, WIRGINIA KUKUŁA-KOCH, NANCY SAANA BANONO, DOROTA NIEOCZYM, KATARZYNA M. TARGOWSKA-DUDA, LIDIA CZERNICKA, JOLANTA PARADA-TURSKA, CAMILA V. ESGUERRA.
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: nr art 7745, str 1-22), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22147745 - link to the publication
  5. Quantitative analysis of phenolic compounds in different types of pickled ginger
    Authors:
    LIDIA CZERNICKA*, WIRGINIA KUKUŁA-KOCH, ZBIGNIEW MARZEC
    Academic press:
    Problemy Higieny i Epidemiologii (rok: 2017, tom: 98, strony: 240-244), Wydawca: Polskie Towarzystwo Higieniczne
    Status:
    Published
    DOI:
    brak - link to the publication
  6. Application of chromatographic and spectroscopic methods towards the quality assessment of ginger (Zingiber officinale) rhizomes from ecological plantations
    Authors:
    WOJCIECH KOCH, WIRGINIA KUKUŁA-KOCH*, ZBIGNIEW MARZEC, ELWIRA KASPEREK, LUCYNA WYSZOGRODZKA-KOMA, WOJCIECH SZWERC, YOSHINORI ASAKAWA
    Academic press:
    International Journal of Molecular Sciences (rok: 2017, tom: 18 (2), strony: art nr 452, str. 1-15), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms18020452 - link to the publication
  7. Influence of thermal processing and in vitro digestion on the antioxidant potential of ginger and ginger containing products
    Authors:
    Influence of thermal processing and in vitro digestion on the antioxidant potential of ginger and ginger containing products. [AUT.] WOJCIECH KOCH, WIRGINIA KUKUŁA-KOCH*, MARCIN DZIEDZIC, KAZIMIERZ GŁOWNIAK, YOSHINORI ASAKAWA
    Academic press:
    Natural Product Communications (rok: 2016, tom: 11, strony: 1153-1156), Wydawca: Natural Product Inc
    Status:
    Published
    DOI:
    brak - link to the publication
  8. MAO-A inhibitory potential of terpene constituents from ginger rhizomes - a bioactivity guided fractionation
    Authors:
    Wirginia Kukula-Koch, Wojciech Koch, Lidia Czernicka, Kazimierz Głowniak, Yoshinori Asakawa, Akemi Umeyama, Zbigniew Marzec, Takashi Kuzuhara
    Academic press:
    Molecules (rok: 2018, tom: 23, strony: 45303), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules23061301 - link to the publication
  9. Superior anticancer activity is demonstrated by total extract of Curcuma longa L. as opposed to individual curcuminoids separated by centrifugal partition chromatography
    Authors:
    WIRGINIA KUKUŁA-KOCH*, ANETA GRABARSKA, JAROGNIEW ŁUSZCZKI, LIDIA CZERNICKA, EWA NOWOSADZKA, EWELINA GUMBAREWICZ, AGATA JARZĄB, GREGOIRE AUDO, SHAKTI UPADHYAY, KAZIMIERZ GŁOWNIAK, ANDRZEJ STEPULAK
    Academic press:
    Phytotherapy Research (rok: 2018, tom: -, strony: 45301), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/ptr.6035 - link to the publication

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