Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The role of GPR39 receptor in the mechanism of antidepressant action

2011/03/B/NZ7/01999

Keywords:

GPR39 receptor depression zinc deficiency antidepressants BDNF neurodegeneration neuroprotection

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ5_3: Pathogenesis of human diseases
  • NZ3_7: Signal transduction

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Katarzyna Młyniec 

Number of co-investigators in the project: 3

Call: OPUS 2 - announced on 2011-09-15

Amount awarded: 655 500 PLN

Project start date (Y-m-d): 2012-08-14

Project end date (Y-m-d): 2016-02-13

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Wirówka (20 000 PLN)
  2. Zautomatyzowana aparatura do testu light/dark box (35 000 PLN)
  3. Płatkarka do lodu ze zbiornikiem do lodu (15 000 PLN)
  4. Gilotyna.
  5. Kolczykownica.
  6. Termoblok/Łaźnia (2 000 PLN)
  7. Zestaw do Western Blot (aparat + zasilacz) (20 000 PLN)
  8. Homogenizator.
  9. Laptop (3 000 PLN)
  10. Mieszadło magnetyczne (2 500 PLN)
  11. Waga analityczna (3 000 PLN)
  12. Wytrząsarka/Kołyska laboratoryjna (2 500 PLN)

Information in the final report

  • Publication in academic press/journals (10)
  • Articles in post-conference publications (2)
  1. Study of antidepressant drugs in GPR39 (zinc receptor⁻/⁻) knockout mice, showing no effect of conventional antidepressants, but effectiveness of NMDA antagonists.
    Authors:
    Młyniec K, Gaweł M, Nowak G.
    Academic press:
    Behavioural Brain Research (rok: 2015, tom: 287, strony: 135-138), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbr.2015.03.053 - link to the publication
  2. GPR39 Zn2+-sensing receptor: A new target in antidepressant development?
    Authors:
    Młyniec K, Singewald N, Holst B, Nowak G.
    Academic press:
    Journal of Affective Disorders (rok: 2015, tom: 174, strony: 89-100), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jad.2014.11.033 - link to the publication
  3. Zinc in the glutamatergic theory of depression
    Authors:
    Młyniec K
    Academic press:
    Current Neuropharmacology (rok: 2015, tom: 13, strony: 45300), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/1570159X13666150115220617 - link to the publication
  4. Essential elements in depression and anxiety. Part I
    Authors:
    Młyniec K, Davies CL, de Agüero Sánchez IG, Pytka K, Budziszewska B, Nowak G.
    Academic press:
    Pharmacological Reports (rok: 2014, tom: 66, strony: 524-544), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharep.2014.03.001 - link to the publication
  5. GPR39 (Zinc Receptor) Knockout Mice Exhibit Depression-Like Behavior and CREB/BDNF Down-Regulation in the Hippocampus
    Authors:
    Młyniec K, Budziszewska B, Holst B, Ostachowicz B, Nowak G.
    Academic press:
    International Journal of Neuropsychopharmacology (rok: 2015, tom: 18, strony: 45299), Wydawca: Oxford Journals
    Status:
    Published
    DOI:
    10.1093/ijnp/pyu002 - link to the publication
  6. The involvement of the GPR39-Zn(2+)-sensing receptor in the pathophysiology of depression. Studies in rodent models and suicide victims.
    Authors:
    Młyniec K, Doboszewska U, Szewczyk B, Sowa-Kućma M, Misztak P, Piekoszewski W, Trela F, Ostachowicz B, Nowak G.
    Academic press:
    Neuropharmacology (rok: 2014, tom: 79, strony: 290-297), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuropharm.2013.12.001 - link to the publication
  7. The role of glutamatergic, GABA-ergic, and cholinergic receptors in depression and antidepressant-like effect.
    Authors:
    Pytka K, Dziubina A, Młyniec K, Dziedziczak A, Żmudzka E, Furgała A, Olczyk A, Sapa J, Filipek B
    Academic press:
    Pharmacological Reports (rok: 2016, tom: 68, strony: 443-50), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.006 - link to the publication
  8. Up-regulation of the GPR39 Zn(2+)-sensing receptor and CREB/BDNF/TrkB pathway after chronic but not acute antidepressant treatment in the frontal cortex of zinc-deficient mice
    Authors:
    Katarzyna Młyniec, Gabriel Nowak
    Academic press:
    Pharmacological Reports (rok: 2015, tom: 67, strony: 1135-40), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharep.2015.04.003 - link to the publication
  9. Immune malfunction in the GPR39 zinc receptor of knockout mice: Its relationship to depressive disorder
    Authors:
    Młyniec K, Trojan E, Ślusarczyk J, Głombik K, Basta-Kaim A, Budziszewska B, Skrzeszewski J, Siwek A, Holst B, Nowak G
    Academic press:
    Journal of Neuroimmunology (rok: 2016, tom: 291, strony: 45603), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jneuroim.2015.12.001 - link to the publication
  10. GPR39 up-regulation after selective antidepressants
    Authors:
    Katarzyna Młyniec, Gabriel Nowak
    Academic press:
    Neurochemistry International (rok: 2013, tom: 62, strony: 936-939), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuint.2013.02.024 - link to the publication
  1. Zinc deficiency versus GPR39-zinc receptor knockout mice in the pathophysiology of depression
    Authors:
    Młyniec K, Budziszewska B, Skrzeszewski J, Holst B, Nowak G.
    Conference:
    27th European College of Neuropsychopharmacology (rok: 2014, ), Wydawca: European Neuropsychopharmacology
    Data:
    konferencja 18-21.10.2014
    Status:
    Published
    DOI:
    link to the publication
  2. The role of the GPR39-Zn2+-sensing receptor in the pathomechanism of depression
    Authors:
    Katarzyna Młyniec, Urszula Doboszewska, Budziszewska Bogusława, Gabriel Nowak
    Conference:
    26th ECNP Congress Barcelona, Hiszpania (rok: 2013, ), Wydawca: European Neuropsychopharmacology, Elsevier
    Data:
    konferencja 5-9.10.2013
    Status:
    Published
    DOI:
    link to the publication

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